American Journal of Clinical and Experimental Medicine

Volume 11, Issue 4, July 2023

  • Research Article

    Effect of 3–3'diindolylmethane (DIM) on Acute Radiation Lung Injury in Mice Via the TGF-β1 Pathway

    Qin Ge

    Issue: Volume 11, Issue 4, July 2023
    Pages: 66-72
    Received: Sep. 02, 2023
    Accepted: Sep. 18, 2023
    Published: Oct. 28, 2023
    Downloads:
    Views:
    Abstract: Objective: We studied the effect of 3–3'diindole methane (DIM) on acute radiation-induced lung injury (RILI) in mice and the possible underlying mechanism. Methods: A total of 45 mice were divided into five groups using the random number table method, namely, blank group, drug group alone (75 mg/kg DIM by peritoneal perfusion), simple irradiation g... Show More
  • Research Article

    Mechanism Study of GanDouLing Mitigating Liver Fibrosis in Wilson’s Disease via Regulating the PI3K/AKT/mTOR Pathway to Activate Autophagy

    Shao-Peng Huang, Sen Chen, Huan Wu, An Zhou, Huai-Zhou Jiang, Hai Bian, Yun-Lai Wang, Zheng-Rong Zhang, Yi-Kang Cai, Hui Jiang, Peng Wu

    Issue: Volume 11, Issue 4, July 2023
    Pages: 73-85
    Received: Sep. 27, 2023
    Accepted: Oct. 25, 2023
    Published: Oct. 30, 2023
    Downloads:
    Views:
    Abstract: The hepatic copper accumulation characteristic of Wilson's disease (WD) leads to activation of hepatic stellate cells, extracellular matrix deposition, and the progression to liver fibrosis (LF), with specific therapeutic interventions for this condition notably deficient. Increasing evidence suggests the potential utility of GanDouLing (GDL) in ad... Show More