American Journal of Clinical and Experimental Medicine

Volume 7, Issue 1, January 2019

  • A Study on the Aberrant Methylation of Colorectal Cancer MLH1 Gene

    Tingting Chen, Hongna Lv, Yanping Xu, Wenjing Du, Rui Zhang

    Issue: Volume 7, Issue 1, January 2019
    Pages: 1-6
    Received: Jan. 17, 2019
    Accepted:
    Published: Feb. 01, 2019
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    Abstract: The aim of this paper is to study the mechanism of MLH1 gene expression and regulation in colorectal cancer, and to clarify the impact of 5' end CpG island aberrant methylation on the regulation of MLH1 gene expression. RT-PCR assay was used to detect the expression of MLH1 gene mRNA in 10 colon cancer cell strains. 62 fresh colorectal adenocarcino... Show More
  • A Japanese Woman with Stevens-Johnson Syndrome without Skin Lesions Induced by an Initial Dosage of Lamotrigine

    Yasuyuki Sumida, Hidetaka Ishino, Atsushi Saitou, Yohei Otsuki, Satoshi Komori, Atsuhiro Kanzaki

    Issue: Volume 7, Issue 1, January 2019
    Pages: 7-11
    Received: Dec. 16, 2018
    Accepted: Feb. 27, 2019
    Published: Mar. 19, 2019
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    Abstract: Atypical Stevens-Johnson syndrome (SJS) which is characterized by little or no skin involment, is reported to be triggered by less medications than infection. There are few reports with atypical SJS induced by medications. This is a case report of atypical SJS induced by Lamotrigine (LTG). A 31-year-old Japanese woman, who was bipolar disorder and ... Show More
  • The Multi-Circuit Neuronal Hyperexcitability Hypothesis of Psychiatric Disorders

    Michael R. Binder

    Issue: Volume 7, Issue 1, January 2019
    Pages: 12-30
    Received: Jan. 15, 2019
    Accepted: Mar. 12, 2019
    Published: Mar. 30, 2019
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    Abstract: After nearly a century of intensive research and clinical investigation, the pathophysiology of psychiatric disorders remains an enigma. Short of a clear understanding of how psychiatric symptoms are produced, the various cognitive, emotional, and behavior patterns that characterize psychiatric disorders continue to be grouped into syndromes and tr... Show More
  • Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance

    Li Hongyan, Xu Qian, Liu Jing, Li Juan

    Issue: Volume 7, Issue 1, January 2019
    Pages: 31-34
    Received: Feb. 18, 2019
    Accepted:
    Published: Apr. 29, 2019
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    Abstract: Objective To discuss the changes of blood lipids, homocysteine (Hcy) and endothelin (ET) levels in patients with hypothyroidism and subclinical hypothyroidism, and to explore their clinical significance. Methods The authors choose 255 cases of hypothyroidism, 274 cases of subclinical hypothyroidism and 130 cases of the control group to test serum T... Show More
  • Survival and Mortality of Patients with Hyponatremia in Intensive Care Units: A Retrospective Study of 327 Patients Hospitalized at Sylvanus Olympio University Hospital

    Eyram Yoan Makafui Amekoudi, Kossi Akomola Sabi, Komlan Georges Tona, Badomta Dolaama, Béfa Noto-Kadou-Kaza, Epiphane Kola, Bayaki Saka

    Issue: Volume 7, Issue 1, January 2019
    Pages: 35-41
    Received: Apr. 23, 2019
    Accepted: Jun. 10, 2019
    Published: Jun. 26, 2019
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    Abstract: Hyponatremia is recognized as the most common electrolyte disorder in hospitalization services. It is associated in the literature with a prolongation of the hospitalization with a variable mortality according to comorbidities and etiologies. In Togo, although empirically noted, this excess mortality has never been demonstrated. The objective of ou... Show More