Research Article
Inflammatory Markers in the Diagnosis of Neonatal Necrotizing Enterocolitis
Yingying Chen,
Yan Pan,
Qihong Fan
Issue:
Volume 11, Issue 5, September 2023
Pages:
86-91
Received:
Oct. 05, 2023
Accepted:
Nov. 01, 2023
Published:
Nov. 09, 2023
DOI:
10.11648/j.ajcem.20231105.11
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Abstract: As a serious gastrointestinal disease in newborns, neonatal necrotizing enterocolitis (NEC) is characterized by an acute onset, rapid progression and high mortality. The pathogenesis of NEC is complex, which makes diagnosis difficult. The diagnostic gold standard of NEC occurs via intestinal biopsy, but this is not feasible for practical clinical applications. Therefore, the diagnosis of NEC at this stage mainly depends on clinical symptoms and abdominal X-ray imaging. However, the clinical symptoms of infants with early NEC are not specific and the characteristic manifestations seen on imaging often only appear during a critical state of NEC, which easily leads to misdiagnosis or the delay of treatment. Thus, finding a reliable diagnostic method to achieve early diagnosis and treatment is necessary to improve prognosis. As a simple and feasible new diagnostic method in the clinic, inflammatory markers have broad application prospects. In this paper, the common inflammatory markers for early diagnosis of NEC are reviewed from the aspects of the molecular mechanism, research status, and feasibility of the clinical application, including serum amyloid A, C-reactive protein, procalcitonin, fecal calprotectin, intestinal fatty acid binding protein, and cytosolic β-glucosidase. Studies have shown that inflammatory markers possess clinical potential for the early diagnosis of NEC, showing more advantages than traditional imaging methods. However, at present, the research is still limited to small sample and single-center research studies, and evidence from large sample sizes, multi-center studies, and multi-inflammatory markers will be needed to support by additional studies in the future.
Abstract: As a serious gastrointestinal disease in newborns, neonatal necrotizing enterocolitis (NEC) is characterized by an acute onset, rapid progression and high mortality. The pathogenesis of NEC is complex, which makes diagnosis difficult. The diagnostic gold standard of NEC occurs via intestinal biopsy, but this is not feasible for practical clinical a...
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Research Article
Retrospective Analysis of Three Different Methods for the Treatment of Macrolide-Unresponsive Mycoplasma Pneumoniae Pneumonia in Children
Issue:
Volume 11, Issue 5, September 2023
Pages:
92-96
Received:
Oct. 23, 2023
Accepted:
Nov. 06, 2023
Published:
Nov. 09, 2023
DOI:
10.11648/j.ajcem.20231105.12
Downloads:
Views:
Abstract: Mycoplasma pneumoniae (MP) is an important cause of community-acquired pneumonia in children and adolescents. We screened 52 children with macrolide-unresponsive Mycoplasma pneumoniae pneumonia hospitalized at our institution from April 2023 to August 2023, and counted and evaluated their treatment modalities and efficacy. Based on the three different drug treatments, we divided all the children into four groups: Group A was the azithromycin oral sequential + glucocorticoid treatment effective group; Group B was the doxycycline oral treatment effective group; Group C was the doxycycline oral + glucocorticoid effective group. By χ2 test, Kruskal-Wallis test, and ann-WhitneyU rank-sum test, we compared the effective cure rate, adjusted hospitalization days, effective fever recovery time, and pulmonary imaging regression under different treatment modalities. We chose three groups of treatment effective cases, A, B and C to analyze. There was no statistically significant difference in the effective cure rate among the three effective groups, P > 0.05; There was a statistically significant difference in the number of adjusted hospitalization days, p < 0.05; There was a statistical difference in the number of adjusted hospitalization days between groups A and B, P < 0.05; There was a statistical difference in the number of adjusted hospitalization days between groups A and C, P < 0.05; There was no statistically significant difference in the number of adjusted hospitalization days between groups B and C, P > 0.05; There was no statistical difference in effective temperature recovery time or lung imaging outcomes among the three groups. From the study, we conclude that the choice of doxycycline or doxycycline and hormone therapy can shorten the number of days of hospitalization and achieve clinical cure more quickly.
Abstract: Mycoplasma pneumoniae (MP) is an important cause of community-acquired pneumonia in children and adolescents. We screened 52 children with macrolide-unresponsive Mycoplasma pneumoniae pneumonia hospitalized at our institution from April 2023 to August 2023, and counted and evaluated their treatment modalities and efficacy. Based on the three differ...
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