American Journal of Clinical and Experimental Medicine

Volume 10, Issue 1, January 2022

  • Neuronal Hyperexcitability: The Elusive But Modifiable Instigator of Disease

    Michael Raymond Binder

    Issue: Volume 10, Issue 1, January 2022
    Pages: 1-7
    Received: Dec. 23, 2021
    Accepted: Jan. 10, 2022
    Published: Jan. 20, 2022
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    Abstract: Despite enormous strides in medical diagnostics and the ability to analyze and track disease processes, the underlying cause of most psychiatric and medical disorders remains unclear. Consequently, the treatment of these disorders continues to be more palliative than preventive. However, an emerging hypothesis contends that severe and persistent st... Show More
  • Appraisal of Therapeutic Impact of One Round of Mass Praziquantel Administration (MPA) on Urinogenital Schistosomiasis in Benue State, Nigeria

    Okete James Agada, Oku Enewan Esien, Asor Joseph Ele, Eme Effiong Etta

    Issue: Volume 10, Issue 1, January 2022
    Pages: 8-14
    Received: Jun. 30, 2021
    Accepted: Jul. 19, 2021
    Published: Jan. 24, 2022
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    Abstract: Preventive chemotherapy through mass administration of praziquantel is the current global schistosomiasis control strategy recommended by the World Health Organization (WHO). We aimed to assess therapeutic impact of one round of mass praziquantel treatment on prevalence and intensity of Schistosoma haematobium infection. Longitudinal studies were c... Show More
  • Prevalence of Plasmodium falciparum Submicroscopic Infection and Pregnancy Outcomes in Congolese Women at Delivery

    Jean Erick Massamba, Jean Claude Djontu, Christevy Jeannhey Vouvoungui, Nerly Chirere Gampio Gueye, Charles Kobawila, Francine Ntoumi

    Issue: Volume 10, Issue 1, January 2022
    Pages: 15-22
    Received: Nov. 22, 2021
    Accepted: Dec. 20, 2021
    Published: Jan. 28, 2022
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    Abstract: Suphodoxine-Pyrimethamine (SP) acts by inhibiting P. falciparum replication, therefore, long term use of SP in malarial endemic sittings as intermittent preventive treatment (IPT) during pregnancy might lead to increased risk of submicroscopic parasitaemia. The present study aimed to determine the prevalence of submicroscopic P. falciparum infectio... Show More
  • New Hypothesis Unifies Previous Theories of Psychopathology and Identifies Core Biological Abnormality in Psychiatric Disorders

    Michael Raymond Binder

    Issue: Volume 10, Issue 1, January 2022
    Pages: 23-37
    Received: Jan. 04, 2022
    Accepted: Jan. 20, 2022
    Published: Jan. 28, 2022
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    Abstract: Despite millennia of philosophical debate and the enormous strides that have been made in neuroscience over the last century, the pathophysiology of psychiatric disorders remains unclear. Although the monoamine hypothesis has, for more than fifty years, provided a strong basis of support for the use of antidepressants in the treatment of depression... Show More
  • New Hypothesis on the Pathophysiology of Psychiatric Disorders Illuminates Shared Mechanism of Past and Emergent Treatment Strategies

    Michael Raymond Binder

    Issue: Volume 10, Issue 1, January 2022
    Pages: 38-48
    Received: Jan. 31, 2022
    Accepted: Feb. 18, 2022
    Published: Feb. 28, 2022
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    Abstract: Although psychotherapy and pharmacotherapy continue to be first-line treatments for a wide range of mental and emotional disorders, a high percentage of patients are ultimately considered to be treatment-resistant. For more than half a century, electroconvulsive therapy had been the gold-standard for such patients. However, in recent years a variet... Show More