Evaluation of Emmenagogue Activity of Aqueous Extract of Cajanus Cajan (Fabaceae) Leaves
Zokore Zazou Ange Kevin,
Kouakou Koffi Roger,
Droucoula Guillaume Cyril,
Yapo Adou Francis
Issue:
Volume 11, Issue 1, March 2023
Pages:
1-7
Received:
12 January 2023
Accepted:
7 February 2023
Published:
14 February 2023
Abstract: The objective of this article is to evaluate emmenagogue activity aqueous extract of Cajanus cajan (fabaceae) leaves in rat. 100 g of leaves powder of Cajanus cajan were added 1 liter from distilled water and mixes it was carried to boiling then filtered. The filtrate was dried with the drying oven, the dried filtrate constitutes the aqueous extract (AECc). For the evaluation of emmenagogue activity, the rates in pseudogestation were used. These rates was obtained by coupling nulliparous and pubescent rates with vasectomized rats (rats made sterile by binding of vas deferens). AECc was managed with the amounts from 12,5 to 600 mg/kg of body weight, as well as the misoprostol with the amount of 2 mg/kg of body weight by oral way. The uterus and blood were taken for respectively the determination of the average weight and for the proportioning of progesterone. The results showed a variation of uterus weight as well as a variation of serum progesterone concentration at rate. AECc effect on the progesterone rate at the rate in pseudogestation gave a significant decrease (p<0.001) progesterone rate to amounts 100; 200; 400 and 600 mg/kg bw compared to control. As for amounts 12.5; 25; and 50 mg/kg bw, the aqueous extract decreased the progesterone rate in a nonsignificant way compared to the control. The aqueous extract of Cajanus cajan thus supports the menstruation with the amounts from 100 to 600 mg/kg bw and relieves of the painful rules to amounts 12.5 to 50 mg/kg bw.
Abstract: The objective of this article is to evaluate emmenagogue activity aqueous extract of Cajanus cajan (fabaceae) leaves in rat. 100 g of leaves powder of Cajanus cajan were added 1 liter from distilled water and mixes it was carried to boiling then filtered. The filtrate was dried with the drying oven, the dried filtrate constitutes the aqueous extrac...
Show More
Effect of Local (Tsumi) and Foreign (Mi Jian Fen) Aphrodisiac on Biochemical Parameters in Wistar Albino Rats
Farida Suleiman Abubakar,
Fatima Aminu,
Moses Zira Zaruwa,
Bawa Yusuf Muhammad,
Titilayo Oluwayemisi Bamidele,
Chibuzo Carole Nweze,
Saratu Steven Audu
Issue:
Volume 11, Issue 1, March 2023
Pages:
8-14
Received:
8 April 2023
Accepted:
2 May 2023
Published:
18 May 2023
Abstract: An aphrodisiac is any substance (i.e. food or drug) that arouses the sexual instinct, increases sexual pleasure and performance. Aphrodisiacs can be classified as natural remedies such as Ambrien, Ginseng and Yohimbine and synthetic aphrodisiacs like ecstasy, synthetic testosterone, phenethylamines and methamphetamine. Tsumi concoction (TC) is a herbal concoction made from Ficus sycomorus, Ginger, Clove, Honey and Brown sugar (Jaggery). Mi Jian Fen (MJF) is an aphrodisiac imported from Spain. This study investigated the effect of TC and MJF aphrodisiacs on biochemical parameters in adult female Wistar albino rats. Adult rats weighing between 160-220g were grouped into six (6) groups with three (3) animals in every group. Group 1 serve as the control, group 2 were administered with 0.2mg/kg of clomid as the standard drug, while group 3 and 4 received high and low (0.4mg/kg and 0.2mg/kg) doses of MJF while group 5 and 6 received high and low (0.4mg/kg and 0.2mg/kg) doses of TC, respectively. The results revealed significant increase (p<0.05) in the ALP and AST levels among all the test groups and a slight increase in ALT compared to the control group. It was followed by significant increase (p<0.05) in serum level of oestrogen and FSH. There was significant increase (p<0.05) in urea and a slight elevations in creatinine levels in all the treated groups. However, moderate changes in the Haematological parameters were also observed. It was concluded that MJF and TC are potent aphrodisiacs with some level of toxicity. Therefore, utilization of MJF and TC which caused kidney and liver damages in albino rats, could have deleterious side effects among human users.
Abstract: An aphrodisiac is any substance (i.e. food or drug) that arouses the sexual instinct, increases sexual pleasure and performance. Aphrodisiacs can be classified as natural remedies such as Ambrien, Ginseng and Yohimbine and synthetic aphrodisiacs like ecstasy, synthetic testosterone, phenethylamines and methamphetamine. Tsumi concoction (TC) is a he...
Show More
