Abstract: Lysine demethylase 5C(KDM5C) is a member of the evolutionarily conserved KDM5 family and act as a histone demethylase to regulate H3K4me2/me3 levels on chromosomes. Recent researches have shown that KDM5C is misregulated in colorectal cancer, liver cancer, gastric cancer, breast cancer, renal cell cancer, prostate cancer and others. KDM5C is involved in the regulation of the expression of tumor-related genes, related to the proliferation, migration, invasion and prognosis of tumor cells. A better understanding of the pathogenetic mechanisms and biologic functions of KDM5C in tumor is expected to provide novel opportunities for the diagnosis and treatment of tumors. This paper reviews the research progress of KDM5C in various tumors.Abstract: Lysine demethylase 5C(KDM5C) is a member of the evolutionarily conserved KDM5 family and act as a histone demethylase to regulate H3K4me2/me3 levels on chromosomes. Recent researches have shown that KDM5C is misregulated in colorectal cancer, liver cancer, gastric cancer, breast cancer, renal cell cancer, prostate cancer and others. KDM5C is involv...Show More
