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Progress in Research of KDM5C in Human Tumors

Received: 25 September 2019     Accepted: 5 November 2019     Published: 18 November 2019
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Abstract

Lysine demethylase 5C(KDM5C) is a member of the evolutionarily conserved KDM5 family and act as a histone demethylase to regulate H3K4me2/me3 levels on chromosomes. Recent researches have shown that KDM5C is misregulated in colorectal cancer, liver cancer, gastric cancer, breast cancer, renal cell cancer, prostate cancer and others. KDM5C is involved in the regulation of the expression of tumor-related genes, related to the proliferation, migration, invasion and prognosis of tumor cells. A better understanding of the pathogenetic mechanisms and biologic functions of KDM5C in tumor is expected to provide novel opportunities for the diagnosis and treatment of tumors. This paper reviews the research progress of KDM5C in various tumors.

Published in Asia-Pacific Journal of Medicine (Volume 2, Issue 3)
Page(s) 21-27
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

KDM5C, Lysine Demethylase 5C, Tumor

References
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  • @article{10043442,
      author = {Zhe Liu and Lingfei Wu},
      title = {Progress in Research of KDM5C in Human Tumors},
      journal = {Asia-Pacific Journal of Medicine},
      volume = {2},
      number = {3},
      pages = {21-27},
      url = {https://www.sciencepublishinggroup.com/article/10043442},
      abstract = {Lysine demethylase 5C(KDM5C) is a member of the evolutionarily conserved KDM5 family and act as a histone demethylase to regulate H3K4me2/me3 levels on chromosomes. Recent researches have shown that KDM5C is misregulated in colorectal cancer, liver cancer, gastric cancer, breast cancer, renal cell cancer, prostate cancer and others. KDM5C is involved in the regulation of the expression of tumor-related genes, related to the proliferation, migration, invasion and prognosis of tumor cells. A better understanding of the pathogenetic mechanisms and biologic functions of KDM5C in tumor is expected to provide novel opportunities for the diagnosis and treatment of tumors. This paper reviews the research progress of KDM5C in various tumors.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Progress in Research of KDM5C in Human Tumors
    AU  - Zhe Liu
    AU  - Lingfei Wu
    Y1  - 2019/11/18
    PY  - 2019
    T2  - Asia-Pacific Journal of Medicine
    JF  - Asia-Pacific Journal of Medicine
    JO  - Asia-Pacific Journal of Medicine
    SP  - 21
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    PB  - Science Publishing Group
    UR  - http://www.sciencepg.com/article/10043442
    AB  - Lysine demethylase 5C(KDM5C) is a member of the evolutionarily conserved KDM5 family and act as a histone demethylase to regulate H3K4me2/me3 levels on chromosomes. Recent researches have shown that KDM5C is misregulated in colorectal cancer, liver cancer, gastric cancer, breast cancer, renal cell cancer, prostate cancer and others. KDM5C is involved in the regulation of the expression of tumor-related genes, related to the proliferation, migration, invasion and prognosis of tumor cells. A better understanding of the pathogenetic mechanisms and biologic functions of KDM5C in tumor is expected to provide novel opportunities for the diagnosis and treatment of tumors. This paper reviews the research progress of KDM5C in various tumors.
    VL  - 2
    IS  - 3
    ER  - 

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Author Information
  • Department of Gastroenterology, The 2nd Affiliated Hospital of Shantou University Medical College, Shantou, China

  • Department of Gastroenterology, The 2nd Affiliated Hospital of Shantou University Medical College, Shantou, China

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