Lysine demethylase 5C(KDM5C) is a member of the evolutionarily conserved KDM5 family and act as a histone demethylase to regulate H3K4me2/me3 levels on chromosomes. Recent researches have shown that KDM5C is misregulated in colorectal cancer, liver cancer, gastric cancer, breast cancer, renal cell cancer, prostate cancer and others. KDM5C is involved in the regulation of the expression of tumor-related genes, related to the proliferation, migration, invasion and prognosis of tumor cells. A better understanding of the pathogenetic mechanisms and biologic functions of KDM5C in tumor is expected to provide novel opportunities for the diagnosis and treatment of tumors. This paper reviews the research progress of KDM5C in various tumors.
| Published in | Asia-Pacific Journal of Medicine (Volume 2, Issue 3) |
| Page(s) | 21-27 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
KDM5C, Lysine Demethylase 5C, Tumor
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APA Style
Zhe Liu, Lingfei Wu. (2019). Progress in Research of KDM5C in Human Tumors. Asia-Pacific Journal of Medicine, 2(3), 21-27.
ACS Style
Zhe Liu; Lingfei Wu. Progress in Research of KDM5C in Human Tumors. Asia-Pac. J. Med. 2019, 2(3), 21-27.
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Download@article{10043442,
author = {Zhe Liu and Lingfei Wu},
title = {Progress in Research of KDM5C in Human Tumors},
journal = {Asia-Pacific Journal of Medicine},
volume = {2},
number = {3},
pages = {21-27},
url = {https://www.sciencepublishinggroup.com/article/10043442},
abstract = {Lysine demethylase 5C(KDM5C) is a member of the evolutionarily conserved KDM5 family and act as a histone demethylase to regulate H3K4me2/me3 levels on chromosomes. Recent researches have shown that KDM5C is misregulated in colorectal cancer, liver cancer, gastric cancer, breast cancer, renal cell cancer, prostate cancer and others. KDM5C is involved in the regulation of the expression of tumor-related genes, related to the proliferation, migration, invasion and prognosis of tumor cells. A better understanding of the pathogenetic mechanisms and biologic functions of KDM5C in tumor is expected to provide novel opportunities for the diagnosis and treatment of tumors. This paper reviews the research progress of KDM5C in various tumors.},
year = {2019}
}
TY - JOUR T1 - Progress in Research of KDM5C in Human Tumors AU - Zhe Liu AU - Lingfei Wu Y1 - 2019/11/18 PY - 2019 T2 - Asia-Pacific Journal of Medicine JF - Asia-Pacific Journal of Medicine JO - Asia-Pacific Journal of Medicine SP - 21 EP - 27 PB - Science Publishing Group UR - http://www.sciencepg.com/article/10043442 AB - Lysine demethylase 5C(KDM5C) is a member of the evolutionarily conserved KDM5 family and act as a histone demethylase to regulate H3K4me2/me3 levels on chromosomes. Recent researches have shown that KDM5C is misregulated in colorectal cancer, liver cancer, gastric cancer, breast cancer, renal cell cancer, prostate cancer and others. KDM5C is involved in the regulation of the expression of tumor-related genes, related to the proliferation, migration, invasion and prognosis of tumor cells. A better understanding of the pathogenetic mechanisms and biologic functions of KDM5C in tumor is expected to provide novel opportunities for the diagnosis and treatment of tumors. This paper reviews the research progress of KDM5C in various tumors. VL - 2 IS - 3 ER -
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