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A Clinical Study of Oxycodone Hydrochloride Prolonged-release Tablets in the Titration of Cancer Pain
Issue:
Volume 2, Issue 4, December 2019
Pages:
28-31
Received:
26 September 2019
Accepted:
5 November 2019
Published:
18 November 2019
Abstract: Objectives: To observe the efficacy and safety of oxycodone hydrochloride prolonged-release tablets in the titration of moderate and severe cancer pain. Methods: 80 outpatients with moderate and severe cancer pain treated with oxycodone hydrochloride prolonged-release tablets were divided into two groups: experimental group used oxycodone hydrochloride prolonged-release tablets per 12h to start titration, control group used oxycodone hydrochloride prolonged-release tablets per 24h to start titration. The effects and adverse effects of two group within 24 hours and 72 hours were observed and compared. Results: After 24hours of titration, pain-relieving objective response rate of experimental group was 75.00%, while control group was 52.50% with statistically significant differences (p<0.05). After 72 hours of titration, the efficiency was 90.00% in experimental group and 87.50% in control group, and the difference was no statistically significant (p>0.05). The main adverse reactions of cancer pain patients were constipation, nausea and vomiting, abdominal distension, drowsiness, dizziness and anorexia apocleisis, and the symptoms all can be tolerated after symptomatic treatment. Conclusions: Oxycodone hydrochloride prolonged- release tablets per 12h to start titration are effective, convenient and rapid in titration of moderate and severe cancer pain.
Abstract: Objectives: To observe the efficacy and safety of oxycodone hydrochloride prolonged-release tablets in the titration of moderate and severe cancer pain. Methods: 80 outpatients with moderate and severe cancer pain treated with oxycodone hydrochloride prolonged-release tablets were divided into two groups: experimental group used oxycodone hydrochlo...
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Application of Atmospheric Low Temperature Plasma in Medicine in the United States
Issue:
Volume 2, Issue 4, December 2019
Pages:
32-39
Received:
16 October 2019
Accepted:
14 November 2019
Published:
27 November 2019
Abstract: Since the mid-1990s, low-temperature plasma discharge has been used as a source of chemical reactants. Its output interacts with biological media, cells and tissues and induces significant effects on organisms. Then, at the beginning of the 21st century, a plasma jet under air conditions was developed to emit cold plasma plumes. However, the biochemical pathways of plasma affecting cells are still poorly understood. This situation has changed quite rapidly, because the field known as plasma medicine today has experienced exponential growth in basic research carried out by global research institutes over the past few years, including the application of cold plasma to inactivate bacteria, heal wounds and necrosis of cancer/cancer cells. Firstly, the physical principle of plasma source produced by equipment used in plasma medicine is briefly introduced. Then, their biomedical applications and future prospects are introduced.
Abstract: Since the mid-1990s, low-temperature plasma discharge has been used as a source of chemical reactants. Its output interacts with biological media, cells and tissues and induces significant effects on organisms. Then, at the beginning of the 21st century, a plasma jet under air conditions was developed to emit cold plasma plumes. However, the bioche...
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Comparative Effect of Patient Controlled Epidural Analgesia and Patient Controlled Intravenous Analgesia After Cesarean Section
Wang Rui,
Chen Xiaoli,
Yang Xiaoying,
Chen Yuanyuan,
Yang Anbo,
Wang Xing
Issue:
Volume 2, Issue 4, December 2019
Pages:
40-44
Received:
4 August 2019
Accepted:
4 December 2019
Published:
20 December 2019
Abstract: Objective: Comparative analysis of analgesic effect and adverse reactions of patient controlled epidural analgesia and intravenous analgesia after cesarean section. Methods:Selection of 60 cases of cesarean section in our hospital from January 2017 to June 2018, Patient controlled analgesia was performed after operation.The patients were randomly divided into two groups: epidural patient-controlled analgesia group (group E) and intravenous patient-controlled analgesia group (group V). Comparison and analysis of pain visual analogue score Pain occurred at 0, 6, 12, 24 and 48 hours after operation in two groups.And adverse reactions (nausea and vomiting, abdominal distension, urinary retention, hypotension, dizziness, respiratory depression). Result: The analgesic effect of group E was slightly higher than that of group V at 0, 6 and 12 hours after operation (VAS score was 2.62±1.82 vs 3.16±1.42, 2.53±1.52 vs 3.35±1.72, 2.33±1.42 vs 3.36±1.22, P＞0.05), but there was no significant difference between the two groups. At 24 and 48 hours, the analgesic effect of the two groups was comparable (pain numerical scores were 2.63±1.21 vs 2.60±1.31, 2.30±1.22 vs 2.24±1.21, P＞0.05). Adverse reactions: The incidence of abdominal distension and urinary retention in group E was significantly higher than that in group V (20.0% vs 6.7%, P < 0.05; 23.3% vs 3.3%, P < 0.05). The incidence of postoperative nausea and vomiting, hypotension, dizziness and respiratory depression in group E was similar to that in group V (P > 0.05).Conclusion: Patient controlled epidural analgesia (PCEA) and intravenous analgesia (PCIA) after cesarean section were both effective, And there was no significant difference in the overall analgesic effect between the two groups. However, the adverse reactions such as abdominal distension and urinary retention in patient-controlled epidural analgesia were significantly higher than those in intravenous analgesia. Postoperative analgesia, nausea and vomiting, hypotension, dizziness and respiratory depression were similar. In clinic, different PCA methods can be selected according to the patient's condition.
Abstract: Objective: Comparative analysis of analgesic effect and adverse reactions of patient controlled epidural analgesia and intravenous analgesia after cesarean section. Methods:Selection of 60 cases of cesarean section in our hospital from January 2017 to June 2018, Patient controlled analgesia was performed after operation.The patients were randomly d...
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Clinical Observation on Cardiopulmonary Function in Patients with Chronic Thromboembolic Pulmonary Hypertension by Cardiopulmonary Exercise Test
Issue:
Volume 2, Issue 4, December 2019
Pages:
45-47
Received:
8 November 2018
Accepted:
17 January 2019
Published:
26 December 2019
Abstract: To analyze the clinical value of cardiopulmonary exercise test in evaluating cardiopulmonary function in patients with chronic thrombotic cardiopulmonary hypertension (CTEPH). patients with chronic thromboembolism (CTEPH) and those with normal physical examination treated in our hospital from January 2016 to December 2018 were treated as CTEPH group, CPE group and normal group respectively. Cardiopulmonary exercise tests were conducted in all three groups, and the results of the three groups wer
Abstract: To analyze the clinical value of cardiopulmonary exercise test in evaluating cardiopulmonary function in patients with chronic thrombotic cardiopulmonary hypertension (CTEPH). patients with chronic thromboembolism (CTEPH) and those with normal physical examination treated in our hospital from January 2016 to December 2018 were treated as CTEPH grou...
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The Value of Conventional Ultrasound Combined with UE and DCE-MRI Combined with DWI in the Diagnosis of Breast Benign and Malignant Lesions
Issue:
Volume 2, Issue 4, December 2019
Pages:
48-52
Received:
5 November 2019
Accepted:
22 December 2019
Published:
31 December 2019
Abstract: Objective: Discuss the value of conventional ultrasound combined with UE and DCE-MRI combined with DWI in the diagnosis of breast benign and malignant lesions.Methods: 60 cases of breast masses confirmed by operation and pathology were analyzed retrospectively Cases were examined by conventional ultrasound combined with ultrasound elastic imaging and double breast MRI before operation. The shape, boundary, enhancement mode, time signal intensity curve (TIC) and apparent diffusion coefficient (ADC) of the lesions were analyzed. The sensitivity and specificity of DCE combined with DWI, conventional ultrasound combined with ultrasound elastic imaging and their combination in the diagnosis of breast lesions were calculated The diagnostic efficiency was analyzed by ROC curve.Results: the sensitivity was 87.5%, the specificity was 80.0%, and the coincidence rate was 85.0%. The diagnostic sensitivity of DCE combined with DWI was 92.5%, the specificity was 90.0%, and the coincidence rate was 91.6%. The combined sensitivity of the two methods was 95.0%, the specificity was 95.0%, and the coincidence rate was 95.0%. The AUC (0.950) of combined differentiation of breast benign and malignant lesions was higher than that of single diagnosis (0.838, 0.913). The difference between combined differentiation and conventional ultrasound combined UE was statistically significant (P < 0.05). Conclusion: conventional ultrasound combined with UE and DCE-MRI combined with DWI have some advantages over single examination in the qualitative diagnosis of breast masses. The combined application of the two is conducive to improve the accuracy of diagnosis.
Abstract: Objective: Discuss the value of conventional ultrasound combined with UE and DCE-MRI combined with DWI in the diagnosis of breast benign and malignant lesions.Methods: 60 cases of breast masses confirmed by operation and pathology were analyzed retrospectively Cases were examined by conventional ultrasound combined with ultrasound elastic imaging a...
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