Abstract: Introduction: Endometrial carcinoma is the sixth most common cancer for females in the world and the seventh most common gynecological cancer in developing countries. The values of platelet indices (MPV, PDW) and red cell distribution width (RDW) are associated with different stages of endometrial and cervical carcinoma. Thus, this study aimed to determine the relation of MPV, PDW, and RDW with endometrial carcinoma. Methods: This cross-sectional study was conducted in the Department of Gynecological Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July 2022 to July 2023. This study included 61 women with histopathologically confirmed endometrial carcinoma (FIGO stage I to IV) as cases and 122 women with histopathologically confirmed benign endometrial disease as the control group. Result: This study found that the case group had a higher mean age (55.62 years vs. 43.75 years). Blood parameter findings showed higher mean MPV (10.46 vs. 9.96) and RDW (46.64 vs. 43.05) in cases. PDW mean was lower in cases (11.33 vs. 14.39). MPV correlated positively with the FIGO stage and histological type, while PDW had a negative correlation. ROC analysis of MPV yielded an AUC of 0.645, with a cut-off of 10.50 showing sensitivity 58%, specificity 72%, and accuracy 57%. ROC analysis of PDW yielded an AUC of 0.789, with a cut-off of 13.50 showing sensitivity 44%, specificity 97%, and accuracy 61%. Multivariant regression revealed MPV to be the strongest factor of endometrial carcinoma (OR-6.20, p=0.039). Conclusion: This study showed that the mean platelet volume (MPV) and red cell distribution width (RDW) are potential markers for detecting endometrial carcinoma.
Abstract: Introduction: Endometrial carcinoma is the sixth most common cancer for females in the world and the seventh most common gynecological cancer in developing countries. The values of platelet indices (MPV, PDW) and red cell distribution width (RDW) are associated with different stages of endometrial and cervical carcinoma. Thus, this study aimed to d...Show More