Research Article
Efficacy of Imatinib According to BCR-ABL Mutation in Patients with CML; Multi-Centered Analytical Study
Satyajit Halder*,
Khaleda Akter Sinthia,
Tasnim Mahmud
Issue:
Volume 13, Issue 2, April 2025
Pages:
47-52
Received:
30 January 2025
Accepted:
13 February 2025
Published:
6 March 2025
DOI:
10.11648/j.ajbls.20251302.11
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Abstract: Background: Imatinib, a name of assurance in the treatment of CML, not only brings significant prognosis and remission but also improves the quality of life of a patient. The study aimed to evaluate the efficacy of Imatinib in CML patients. Methods: This study was cross-sectional and multi-centered, starting from 2019-2024 from Sylhet, Chittagong, and Rajshahi. In this study, 529 patients were enrolled. Among them, 442 patients were taken, rest of the patients declined as BCR- ABL1 observed copies were <10,000. Sampling was done by convenient technique. Result: The patients' ages ranged from under 20 to over 80 years, with the majority falling between 21-30 years (25.71%) and 31-40 years (23.25%). The majority of the patients were male (57.66%). According to the analytical result, 442 patients (83.55%) tested positive. Among the 442 participants who tested positive for BCR-ABL1 mRNA, 155 patients (35.07%) were in remission. In contrast, 287 patients (64.93%) were not in remission, with an IS ratio greater than 0.1%. Among the 155 patients classified as in remission according to the IS ratio (≤0.1%), all 155 (100.00%) were also in remission according to the transcript percent ratio (≤10%). The sensitivity of the transcript percent ratio in identifying patients in remission was 100.00%, indicating that all patients in remission according to the IS categorization were also identified as in remission by the transcript percent ratio. The specificity was 36.60%, reflecting a lower ability to correctly identify patients not in remission. Conclusion: In the case of specificity, International-scale and large-scale clinical studies with long-term patient outcomes are more recommended.
Abstract: Background: Imatinib, a name of assurance in the treatment of CML, not only brings significant prognosis and remission but also improves the quality of life of a patient. The study aimed to evaluate the efficacy of Imatinib in CML patients. Methods: This study was cross-sectional and multi-centered, starting from 2019-2024 from Sylhet, Chittagong, ...
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Research Article
Occurrence of Geohelminthes in Four Major Markets in Makurdi Metropolis, Benue State, Nigeria
Okita Faith Odije*,
Hosea Zakki Yula,
Ekpa Promise Joel
Issue:
Volume 13, Issue 2, April 2025
Pages:
53-58
Received:
3 March 2025
Accepted:
22 March 2025
Published:
17 April 2025
Abstract: Soil serves as a reservoir for infective stages of helminthes that affect both man and animals. The study surveyed the occurrence of geohelminthes in four major markets in Makurdi, Benue State, Nigeria. Following standard procedures, 50 soil samples each were collected from various sites in the four major markets (Wadata, Wurukum, High-Level and Northbank) in Makurdi metropolis. The samples were processed for helminthes in the Zoology Laboratory of Benue State University, using the zinc sulphate floatation method. Following isolation and identification of helminthes from infected samples, the data were presented using descriptive statistics (Simple percentages). A total of 85/200 (42.50%) helminthes prevalence was documented in the study, and these were: Taenia sp 7/85 (8.24%), Trichuris trichuria 10/85 (11.76%), Strongyloides stercoralis 13/85 (15.30%), Hookworm 16/85 (18.82%) and Ascaris lumbricoides 39/85 (45.88%). Location-based prevalence of helminthes included: 5/85 (5.88%) in High-level, 16/85 (18.82%) in Northbank, 30/85 (35.29%) in Wurukum and 34/85 (40.00%) in Wadata markets respectively. The toilet 38/85 (44.71%) area was the most infected, followed by refuse dumps 36/85 (42.35%) and the playground 11/85 (12.94%). Periodical documentation of geohelminthes of public health importance is key to achieving proper control. Helminthes documented in the study calls for concern and studies involving advanced technologies to build on the current data are encouraged.
Abstract: Soil serves as a reservoir for infective stages of helminthes that affect both man and animals. The study surveyed the occurrence of geohelminthes in four major markets in Makurdi, Benue State, Nigeria. Following standard procedures, 50 soil samples each were collected from various sites in the four major markets (Wadata, Wurukum, High-Level and No...
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