Research Article
Success Rate of Vaginal Birth After Cesarean Section and Associated Factors Among Women Who Gave Birth at Adama Hoapital Medical College
Tayachew Desalegn Bekele*
,
Tesfaye Getachew Charkos,
Heran Ararsa
Issue:
Volume 11, Issue 2, April 2025
Pages:
16-23
Received:
13 January 2025
Accepted:
5 March 2025
Published:
21 March 2025
Abstract: Background; Vaginal Birth After cesarean section (VBAC) is considered a viable and safe option for many women who have previously undergone a cesarean section, particularly when the initial cesarean section was performed for a non-recurring indication. Studies indicates that VBAC can lead to lower rates of maternal complications and faster recovery times with success rate of 60-80% compared to elective repeat cesarean deliveries. Objective; to assess success rate of vaginal birth after cesarean section and factors associated with VBAC in woman who gave birth at AHMC in 2024. Method; institutional based cross-sectional study was conducted at AHMC involving 208 mothers who had undergone one previous cesarean section. Data were collected using a structured checklist that was pretested prior to the study. The collected data were entered and cleaned using Epi-data version 3.7 and analyzed with SPSS version 24 to determine frequency distributions, means, and standard deviations. Bivariate and Multivariate logistic regression analyses were performed to evaluate the success rate of vaginal birth after cesarean section and to identify factors associated with VBAC. A 95% confidence interval and 5% level precision were used to determine the presence of associations between and independent variables in the final model. Result; the total number of mothers with one previous cesarean section who were offered trial of labor and included in this study were 208. Out of these 86 (41.3%) with CI (34.59%-48.09%) had successful vaginal birth. Independent variables history of pervious VBAC (AOR=6.306 [1.143-34.802]), rupture of membrane at admission [AOR=5.758 [2.588-12.812] and Low station at admission [AOR=6.807 [2.34-19.796] are highly associated with VBAC. Conclusion; The study concluded that the overall success rate of Vaginal Birth after Cesarean (VBAC) in this research is consistent with findings from earlier studies conducted in Ethiopia. Key factors identified as predictors of VBAC success include a prior history of vaginal delivery following a cesarean section (C/S) scar, low fetal station, and membrane rupture. These elements play a significant role in determining the likelihood of a successful VBAC.
Abstract: Background; Vaginal Birth After cesarean section (VBAC) is considered a viable and safe option for many women who have previously undergone a cesarean section, particularly when the initial cesarean section was performed for a non-recurring indication. Studies indicates that VBAC can lead to lower rates of maternal complications and faster recovery...
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Research Article
The Expression and Role of MAN2A1 in Triple-negative Breast Cancer
Issue:
Volume 11, Issue 2, April 2025
Pages:
24-31
Received:
20 April 2025
Accepted:
3 May 2025
Published:
18 June 2025
DOI:
10.11648/j.ejcbs.20251102.12
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Abstract: Background: Triple-negative breast (TNBC) cancer responds poorly to surgery, radiotherapy, chemotherapy, and endocrine therapy, it is considered the subtype of breast cancer with the worst prognosis. This study investigated MAN2A1's role in regulating the proliferation, invasion, and migration of TNBC cells and its clinical significance. Methods: We enrolled 220 TNBC patients treated at our institution from January 2020 to December 2022. MAN2A1 protein expression was detected, and its correlation with TNBC clinicopathological features was analyzed. Western blot and immunohistochemistry measured MAN2A1 protein levels. CCK-8, colony formation, and EdU assays evaluated MAN2A1's impact on TNBC cell proliferation. Wound healing and Transwell assays assessed its effects on migration and invasion. Results: MAN2A1 protein expression positively correlated with TNBC malignancy. MAN2A1 is overexpressed in larger tumors (≥2 cm), lymph node metastasis-positive cases, and advanced-stage (III-IV) patients. Functional assays demonstrated that MAN2A1 overexpression promoted TNBC cell growth, clonogenicity, migration, and invasion, while its knockdown suppressed these processes. Conclusion: This study systematically elucidates the role of MAN2A1 as a key glycosylation-modifying enzyme in promoting the malignant progression of TNBC. The experimental results demonstrate that MAN2A1 drives TNBC development by enhancing cellular proliferation, invasive capacity, and migratory potential, providing a theoretical basis for developing targeted therapeutic strategies against MAN2A1.
Abstract: Background: Triple-negative breast (TNBC) cancer responds poorly to surgery, radiotherapy, chemotherapy, and endocrine therapy, it is considered the subtype of breast cancer with the worst prognosis. This study investigated MAN2A1's role in regulating the proliferation, invasion, and migration of TNBC cells and its clinical significance. Methods: W...
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