Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures

Shweta Singh; Santosh K. Sar; Tonmoy Ray

doi:doi:10.11648/j.sr.20160405.12

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Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures

Shweta Singh, Santosh K. Sar, Tonmoy Ray

Published in Science Research (Volume 4, Issue 5)

Received: 22 September 2016 Accepted: 21 October 2016 Published: 25 November 2016

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Abstract

To get accurate concentration of drug in systemic way for pharmacological response, Solubility is an important parameter to be shown. Most of the newly discovered chemical entities of the drugs are subjected to lipid lover (lipophile) due to this it carries the properties of poor water solubility. That’s why solubility behavior is one of the most important for formational developments [24, 25]. Colloidal drug has to be in desired properties for the development of drug carrier, it is essential to examine physico-chemical properties of the systems. Bile salt mixed micelles are globally known as novel for drug delivery systems in living organism. The main purpose of the present method is to develop and examine the characterize mixed micelles [3] of anionic bile salts (Sodium deoxycholate and sodium cholate) and drug (Disprine or generic name Aspirin) in various temperatures.

Published in	Science Research (Volume 4, Issue 5)
DOI	10.11648/j.sr.20160405.12
Page(s)	112-119
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Bile Salts- Sodium Cholate, Sodium deoxycholate, Conductometer, Disprine, cmc, Counter Ion Dissociation, Micelle

References

[1]	D. M. Ćirin et al, (2012), Dodecyl sulfate–non ionic surfactant mixed micelles hem. Ind. 66 (1) 21–28.
[2]	Dejan M. Cirin, Mihalj M. Posa, Veljko S. Krstonosic, MajaLj. Milanovic, (2012), Cconductometric study of Sodium dodecylsulfate- non- ionic Surfactants (Triton X-100, A tween 20, Tween 60, Tween 80 or Tween 85) mixed micelle in aqueous solution, Hem. Ind, 66 (1), 21-28.
[3]	Dejan M. Cirin, Mihalj M. Posa, Veljko S., 2011, Interactions between selected bile salts and Triton X-100 or sodium lauryl ether sulfate, Chemistry Central Journal 5:89.
[4]	G. Moodssac, A. Al-Wardian, K. Glennand R. Palepu, (2004), Can J Chem, 82, 1774.
[5]	I. A. Khan, A. J. Khanam, M. S. Sheikh, Kabir –ud -Din, (2011), Influence of ionic and non ionic hydro tropeson micellar behaviour of a cationic Gemini surfactant but anediyl- 1, 4-bis (di methyl cetyl ammonium bromide), J. Colloid. Interface, 15; 359 (2): 467-73.
[6]	J. Piret, A. Désormeaux, M. G. Bergeron, (2002), Sodium lauryl sulfate, a microbicide effective against enveloped and non enveloped viruses, Curr. Drug Targets 3, 17–30.
[7]	J. Piret, Lamontagne J, Bestman- Smith J, S. Roy, P. Gourde, A. Désormeaux, R. F. Omar, J. Juhász, M. G. Bergeron, (2000), In vitro and in vivo evaluations of sodium lauryl sulfate and dextran sulfate as micro bicides against herpes simplex and human immune deficiency viruses, 38 (1): 110.
[8]	J. L. Palous, M. Turmine, P. Letellier, (1998), Mixtures of non- ionic and ionic surfactants: Determination of mixed micelle composition using cross- differentiation relations, J. Phys. Chem., B 102, 5886–5890.
[9]	Kabir- ud- Din, Rub M A, Naqvi A Z, (2011), Aqueous amphiphilic drug (amitriptyline hydrochloride)-bile salt mixtures at different temperatures, Colloids Surf B Biointerfaces, 84 (2): 285-91.
[10]	Kabir-ud-Din, Rub M A, Naqvi A Z, (2010), Mixed micellization of antidepressant drug amitriptyline hydrochloride with cationic surfactants, Colloids Surf B Biointerfaces, 80 (2): 206-12, E pub 2010 Jun 19.
[11]	Kallol K Ghosh and Vidyacharan Baghel, (2008), Indian Journal of chemistry, Vol. 47A, 1230-1233.
[12]	M. J. Rosen, D. Murphy, (1986), Synergism in binary mixtures of surfactants: V. Two- phase liquid—liquid systems at low surfactant concentrations, J. Colloid Interface Sci. 110, 224–236.
[13]	M. Jahirul Islam, M. M. R. Choundri, S. M. F. Shahed, M. A. Subhan, (2009), Effect of some biologically important organic compounds on the micellar properties of sodium dodecyl sulphate, Proc. Pak. Acad. Sci. 46, 91–95.
[14]	M. J. Rosen, B. Y. Zhu, (1986), Synergism in binary mixtures of surfactant: III. Betaine- containing systems, J. Colloid Interface Sci. 99, 427–434.
[15]	M. N. Shala by, (2008), Synergistic behaviour of binary mixed micellar solution, J. Dispersion Sci. Technol. 29, 447–452.
[16]	Das A K, Hajra A K, (1992), Critical micellar concentrations of palmitoyl dehydroxy acetone phosphate and 1- palmitoyl-rac- glycerol 3- phosphate, J Biol Chem, 267, 14, 9731.
[17]	Mazer N A, (1985), Laser Light Scattering in Micellar systems in 'Dynamic Light Scattering: Applications' by R Pecora, Springer, 305-346.
[18]	Mohammad Safi, (2013), Aggregation behavior of amphiphilic drug and bile salt mixtures at different compositions and temperatures, The Journal of Chemical Thermodynamics, 64: 28–39.
[19]	Navas A., Dı az, Garcı aF., Sa nchez, A. Garcı a Pareja, (1998), Cholic acid behavior in water and organic solvent: study of normal and inverted aggregates, 142, 27–34
[20]	Nighat Razvi, Saeed Ahmad Siddiqui and Lubna Ghazal Khan, (2005), The effect of surfactant on the dissolution rate of ibuprofen tablet sinti. Chern. Pharm. Med. J. Vol. 2 (1), pp. 213-216.
[21]	O. López, M. Cócera, E. Wehrli, J. L. Parra, A. De La Maza, (1999), Solubilization of liposomes by sodium dodecyl sulfate: new mechanism based on the direct formation of mixed micelles, Arch. Biochem. Biophys. 367, 153–160.
[22]	Piszkichwicz D., (1977), Kinetics Study of Malachite Green Fading, J. Am. Chem. Soc, 99, 7695.
[23]	Prajapati K. and Patel S., 2012, Micellization of Surfactants in Mixed Solvent of Different Polarity, Archives of Applied Science Research, 4 (1): 662-668.
[24]	Reflection paper on the pharmaceutical development of intravenous medicinal products containing active substances solubilised in micellar systems, (05 March 2012), EMA/ CHMP/ QWP/ 799402/ 2011Compliance and Inspection.
[25]	Reflection paper on the pharmaceutical development of intravenous medicinal products containing active substances solubilised in micellar systems (non-polymeric surfactants), 23 Sep 2010 EMA/ CHMP/ QWP/ 799402/ 2011Compliance and Inspection.
[26]	Sar Santosh K. and Rathod Nutan, (2011), Mixed micelle formation between amino acid-based surfactants and phospholipids. Sci. 359, 467–473.
[27]	Sandhiya Jatwani, Avtarchand Rana, Gurpreet Singh and Geeta Aggarwal, (2004), An over view on solubility enhancement techniques for poorly soluble drugs and solid dispersion as an eminent strategic approach, IJPSR (2012), vol. 3, issue 04.
[28]	S. A. Baeurte, and J. Kroener, (2004), Modeling effective interactions of micellar aggregates of ionic, J Math Chem. 36: 409–421.
[29]	Santanu Paria, (2006), The mixing behavior of n-alkylpyridinium bromide– NP- mixed surfactant systems, Colloids of surface, 281, 1-3, 113-118.
[30]	Shweta & Santosh k Sar, (2014), Micellization of some bile salt in binary aqueous solvent mixture, J of surfactants & Detergent, 17, 143-150.
[31]	Tiwari S. and Ghosh K. K.; (2008), Micellization of cetyltributylphosphonium Bromide in some Binary Aqueous Solvents mixtures, Tenside Surf. Det., 45, 5.
[32]	Saeed Ahmad Siddiqui, Nighat Razvi, and Lubna Ghazal Khan, 2005, the effect of surfactant on the dissolution rate of ibuprofen tablets, in ti. chern. pharm. med. j. vol. 2 (1), pp. 213-216.
[33]	Sujeet kumar chatterjee and tulasi Prasad niraula, ajaya bhattarai et al (2013), effects of concentration, temperature and solvent composition on density and apparent molar volume of the binary mixtures of cationic-anionic surfactants in methanol– water mixed solvent media, springer plus, 2:280.
[34]	Williamn. charman, Christopher J. H. Porter, Sabena Mithani, Jennifer B. Dressman, (1997), Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH, Volume 86, Issue 3, Pages 269–282.

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APA Style

Shweta Singh, Santosh K. Sar, Tonmoy Ray. (2016). Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures. Science Research, 4(5), 112-119. https://doi.org/10.11648/j.sr.20160405.12

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ACS Style

Shweta Singh; Santosh K. Sar; Tonmoy Ray. Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures. Sci. Res. 2016, 4(5), 112-119. doi: 10.11648/j.sr.20160405.12

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AMA Style

Shweta Singh, Santosh K. Sar, Tonmoy Ray. Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures. Sci Res. 2016;4(5):112-119. doi: 10.11648/j.sr.20160405.12

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@article{10.11648/j.sr.20160405.12,
  author = {Shweta Singh and Santosh K. Sar and Tonmoy Ray},
  title = {Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures},
  journal = {Science Research},
  volume = {4},
  number = {5},
  pages = {112-119},
  doi = {10.11648/j.sr.20160405.12},
  url = {https://doi.org/10.11648/j.sr.20160405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sr.20160405.12},
  abstract = {To get accurate concentration of drug in systemic way for pharmacological response, Solubility is an important parameter to be shown. Most of the newly discovered chemical entities of the drugs are subjected to lipid lover (lipophile) due to this it carries the properties of poor water solubility. That’s why solubility behavior is one of the most important for formational developments [24, 25]. Colloidal drug has to be in desired properties for the development of drug carrier, it is essential to examine physico-chemical properties of the systems. Bile salt mixed micelles are globally known as novel for drug delivery systems in living organism. The main purpose of the present method is to develop and examine the characterize mixed micelles [3] of anionic bile salts (Sodium deoxycholate and sodium cholate) and drug (Disprine or generic name Aspirin) in various temperatures.},
 year = {2016}
}

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TY  - JOUR
T1  - Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures
AU  - Shweta Singh
AU  - Santosh K. Sar
AU  - Tonmoy Ray
Y1  - 2016/11/25
PY  - 2016
N1  - https://doi.org/10.11648/j.sr.20160405.12
DO  - 10.11648/j.sr.20160405.12
T2  - Science Research
JF  - Science Research
JO  - Science Research
SP  - 112
EP  - 119
PB  - Science Publishing Group
SN  - 2329-0927
UR  - https://doi.org/10.11648/j.sr.20160405.12
AB  - To get accurate concentration of drug in systemic way for pharmacological response, Solubility is an important parameter to be shown. Most of the newly discovered chemical entities of the drugs are subjected to lipid lover (lipophile) due to this it carries the properties of poor water solubility. That’s why solubility behavior is one of the most important for formational developments [24, 25]. Colloidal drug has to be in desired properties for the development of drug carrier, it is essential to examine physico-chemical properties of the systems. Bile salt mixed micelles are globally known as novel for drug delivery systems in living organism. The main purpose of the present method is to develop and examine the characterize mixed micelles [3] of anionic bile salts (Sodium deoxycholate and sodium cholate) and drug (Disprine or generic name Aspirin) in various temperatures.
VL  - 4
IS  - 5
ER  -

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Author Information

Shweta Singh

Department of Applied Chemistry, Bhilai Institute of Technology, Durg, (C.G.) India
Santosh K. Sar

Department of Applied Chemistry, Bhilai Institute of Technology, Durg, (C.G.) India
Tonmoy Ray

Department of Biotechnology, National Institute of Technology, Durgapur, (W.B.) India

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APA Style

Shweta Singh, Santosh K. Sar, Tonmoy Ray. (2016). Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures. Science Research, 4(5), 112-119. https://doi.org/10.11648/j.sr.20160405.12

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ACS Style

Shweta Singh; Santosh K. Sar; Tonmoy Ray. Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures. Sci. Res. 2016, 4(5), 112-119. doi: 10.11648/j.sr.20160405.12

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AMA Style

Shweta Singh, Santosh K. Sar, Tonmoy Ray. Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures. Sci Res. 2016;4(5):112-119. doi: 10.11648/j.sr.20160405.12

Copy | Download

@article{10.11648/j.sr.20160405.12,
  author = {Shweta Singh and Santosh K. Sar and Tonmoy Ray},
  title = {Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures},
  journal = {Science Research},
  volume = {4},
  number = {5},
  pages = {112-119},
  doi = {10.11648/j.sr.20160405.12},
  url = {https://doi.org/10.11648/j.sr.20160405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sr.20160405.12},
  abstract = {To get accurate concentration of drug in systemic way for pharmacological response, Solubility is an important parameter to be shown. Most of the newly discovered chemical entities of the drugs are subjected to lipid lover (lipophile) due to this it carries the properties of poor water solubility. That’s why solubility behavior is one of the most important for formational developments [24, 25]. Colloidal drug has to be in desired properties for the development of drug carrier, it is essential to examine physico-chemical properties of the systems. Bile salt mixed micelles are globally known as novel for drug delivery systems in living organism. The main purpose of the present method is to develop and examine the characterize mixed micelles [3] of anionic bile salts (Sodium deoxycholate and sodium cholate) and drug (Disprine or generic name Aspirin) in various temperatures.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Aggregation Behaviour of Sodium Cholate and Sodium Deoxycholate Under the Influence of Drug (Disprine) in Aqueous Solution at Various Temperatures
AU  - Shweta Singh
AU  - Santosh K. Sar
AU  - Tonmoy Ray
Y1  - 2016/11/25
PY  - 2016
N1  - https://doi.org/10.11648/j.sr.20160405.12
DO  - 10.11648/j.sr.20160405.12
T2  - Science Research
JF  - Science Research
JO  - Science Research
SP  - 112
EP  - 119
PB  - Science Publishing Group
SN  - 2329-0927
UR  - https://doi.org/10.11648/j.sr.20160405.12
AB  - To get accurate concentration of drug in systemic way for pharmacological response, Solubility is an important parameter to be shown. Most of the newly discovered chemical entities of the drugs are subjected to lipid lover (lipophile) due to this it carries the properties of poor water solubility. That’s why solubility behavior is one of the most important for formational developments [24, 25]. Colloidal drug has to be in desired properties for the development of drug carrier, it is essential to examine physico-chemical properties of the systems. Bile salt mixed micelles are globally known as novel for drug delivery systems in living organism. The main purpose of the present method is to develop and examine the characterize mixed micelles [3] of anionic bile salts (Sodium deoxycholate and sodium cholate) and drug (Disprine or generic name Aspirin) in various temperatures.
VL  - 4
IS  - 5
ER  -

Copy | Download