@article{10.11648/j.ijpc.20190505.11,
  author = {Marothu Vamsi Krishna and Salah Ali Mahgoub Idris and G. Madhavi and B. Jalachandra Reddy and M. Sowhardhra and D. Gowri Sankar},
  title = {Study on Dissociation Equilibria of Eberconazole Nitrate in Micellar Media by Spectrophotometry},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {5},
  number = {5},
  pages = {48-51},
  doi = {10.11648/j.ijpc.20190505.11},
  url = {https://doi.org/10.11648/j.ijpc.20190505.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20190505.11},
  abstract = {The equilibrium dissociation constant (KD) is the basic parameter to evaluate the binding property of the chemical structure of compounds. Thus, a variety of analytical methods have been established to determine the KD values, including radioligand binding assay, surface plasmon resonance method, fluorescence energy resonance transfer method, affinity chromatography, and isothermal titration calorimetry. Here we present a detailed overview of the dissociation equilibria of Eberconazole nitrate (EBZ) in homogeneous and heterogeneous systems, focusing primarily on methods that are based on spectrophotometrically of the dissociation reaction. The Dissociation equilibria of Eberconazole nitrate (EBZ) in homogeneous and heterogeneous systems were studied spectrophotometrically in Britton-Robinson’s (BR) buffer at 25°C. Acidity constant of EBZ in BR buffer was found to be 9.5. The effect of anionic, cationic and non-ionic surfactants applied in the concentration exceeding critical micellar concentration (cmc) on acid – base properties of EBZ were also examined. The results revealed a shift of pKa values in micellar media comparing to the values obtained in BR buffer. These shifts in pKa values are more in cationic and anionic micellar media compared with that of non-ionic. The observed differences in pKa values between micellar media and BR buffer solution ranged between -6.0 to -2.0 units. The micellar-mediated pKa shifts can be attributed to the differences between the mean intrinsic solvent properties of the interfacial and bulk phases, with an additional contribution from the electrostatic micellar surface potential in the case of the charged aqueous micellar solutions.},
 year = {2019}
}

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TY  - JOUR
T1  - Study on Dissociation Equilibria of Eberconazole Nitrate in Micellar Media by Spectrophotometry
AU  - Marothu Vamsi Krishna
AU  - Salah Ali Mahgoub Idris
AU  - G. Madhavi
AU  - B. Jalachandra Reddy
AU  - M. Sowhardhra
AU  - D. Gowri Sankar
Y1  - 2019/10/11
PY  - 2019
N1  - https://doi.org/10.11648/j.ijpc.20190505.11
DO  - 10.11648/j.ijpc.20190505.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 48
EP  - 51
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20190505.11
AB  - The equilibrium dissociation constant (KD) is the basic parameter to evaluate the binding property of the chemical structure of compounds. Thus, a variety of analytical methods have been established to determine the KD values, including radioligand binding assay, surface plasmon resonance method, fluorescence energy resonance transfer method, affinity chromatography, and isothermal titration calorimetry. Here we present a detailed overview of the dissociation equilibria of Eberconazole nitrate (EBZ) in homogeneous and heterogeneous systems, focusing primarily on methods that are based on spectrophotometrically of the dissociation reaction. The Dissociation equilibria of Eberconazole nitrate (EBZ) in homogeneous and heterogeneous systems were studied spectrophotometrically in Britton-Robinson’s (BR) buffer at 25°C. Acidity constant of EBZ in BR buffer was found to be 9.5. The effect of anionic, cationic and non-ionic surfactants applied in the concentration exceeding critical micellar concentration (cmc) on acid – base properties of EBZ were also examined. The results revealed a shift of pKa values in micellar media comparing to the values obtained in BR buffer. These shifts in pKa values are more in cationic and anionic micellar media compared with that of non-ionic. The observed differences in pKa values between micellar media and BR buffer solution ranged between -6.0 to -2.0 units. The micellar-mediated pKa shifts can be attributed to the differences between the mean intrinsic solvent properties of the interfacial and bulk phases, with an additional contribution from the electrostatic micellar surface potential in the case of the charged aqueous micellar solutions.
VL  - 5
IS  - 5
ER  - 

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