Research Article
Prodrugs: A Novel Approach of Drug Delivery
Rishabh Gaur*
Issue:
Volume 10, Issue 2, April 2024
Pages:
18-24
Received:
23 May 2024
Accepted:
15 June 2024
Published:
29 June 2024
DOI:
10.11648/j.ijpc.20241002.11
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Abstract: In the last one-decade numbers of review and research, articles have been published on prodrugs. This shows the interest of researchers in prodrugs because of the advantages offered by them over other drug delivery systems. Prodrug design is a method to focus many of the issues that trouble drug discovery and development, such as solidity, virulence, solubility, permeability, and drug targeting. Prodrug design is an effective method for targeting medications by altering their physiochemical, pharmacological, or pharmacokinetic properties. Prodrugs account for about 10% to 14% of all drugs sanctioned worldwide. Prodrugs can be created for a variety of administration methods, including transdermal, oral, intravenous, and more. However, the oral route of administration is the most popular and preferable approach; hence, oral prodrugs are highlighted in this article. Our main objectives are to explain the fundamental ideas behind the prodrug strategy, give a rundown of successfully registered oral prodrugs, and evaluate the therapeutic gains made in contrast to the parent drug. In this review article, we have made an attempt to incorporate all the basic details of prodrugs like Introductions, classification, applications of prodrug design in diverse fields of drug development, and basic functional categories that are amenable to prodrug design are all covered in this article. Using electronic databases such Web of Science, Google Scholar, PubMed, Sci Finder, Reaxys, and Cochrane, a literature search was conducted to locate information.
Abstract: In the last one-decade numbers of review and research, articles have been published on prodrugs. This shows the interest of researchers in prodrugs because of the advantages offered by them over other drug delivery systems. Prodrug design is a method to focus many of the issues that trouble drug discovery and development, such as solidity, virulenc...
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Research Article
Sleep Potentiating Effect of Pleurotus squarrusolus Ethanolic Extract on Diazepam-Induced Sleeping Time in Male Wistar Rats
Akingbeoste Babajide Oluwaseun*,
Sule Ola Salawu
Issue:
Volume 10, Issue 2, April 2024
Pages:
25-28
Received:
17 August 2024
Accepted:
7 September 2024
Published:
18 October 2024
Abstract: This study examines the sleep-promoting properties of an ethanolic extract derived from Pleurotus squarrosulus in male Wistar rats, particularly in conjunction with the sleep-inducing effects of diazepam. The impetus for this research is driven by the rising global incidence of sleep disorders and the ongoing need for effective, natural adjuncts to current therapeutic strategies. The bioactive compounds identified in Pleurotus squarrosulus may exert mood-modulating effects, which could play a role in its overall therapeutic impact on sleep and well-being. The extract was subjected to analysis using High-Performance Liquid Chromatography (HPLC), which revealed the presence of gallic acid, p-coumaric acid, ferulic acid, catechin, rutin, apigenin, quercetin, and kaempferol. Among these compounds, gallic acid and quercetin exhibited the highest concentrations. Diazepam, a traditional sedative, was administered alone as well as in combination with two different doses of the extract, namely 250mg and 500mg. The results demonstrated a significant increase in sleeping time in both the Diazepam + Sample 250mg and Diazepam + Sample 500mg groups compared to the control group, indicating an enhancement in sleep quality. These findings are consistent with previous research, which highlighted the presence of bioactive compounds known for their diverse biological effects. This study introduces Pleurotus squarrosulus as a potential natural sleep aid, showcasing a promising synergy when combined with diazepam. Further investigation into the mechanisms and safety considerations of this combination offers an optimistic path for the development of integrated approaches to sleep management.
Abstract: This study examines the sleep-promoting properties of an ethanolic extract derived from Pleurotus squarrosulus in male Wistar rats, particularly in conjunction with the sleep-inducing effects of diazepam. The impetus for this research is driven by the rising global incidence of sleep disorders and the ongoing need for effective, natural adjuncts to...
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