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Factors Associated with Virological Suppression of HIV Viral Load in Patients on Antiretroviral Therapy in Conakry, Guinea

Received: 1 February 2022     Accepted: 25 February 2022     Published: 3 March 2022
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Abstract

Viral load testing is a key indicator for assessing ART success and diagnosing drug resistance in people living with HIV/AIDS on antiretroviral therapy. This study aimed to assess virological suppression among people living with HIV / AIDS on antiretroviral therapy in Guinea. This was a three years descriptive cross-sectional that involved adult HIV-positive patients treated in different sites in Conakry. The study population consisted of patients living with HIV/AIDS, followed up at Conakry ART care and treatment sites, samples collected from the study population were sent to the National Institute of Public Health for viral load testing between January 2018 and June 2021. The viral load was quantified by the Generic Biocentric technique and the detection threshold set at 350 copies/ml. Factors associated with virological suppression were analysed by univariate or multivariate logistic regression. Statistical analysis were performed by R software version R4.0.3. A total of 9815 samples were collected and viral load data analyzed at the national public health laboratory. The sample was dominated by women (72%), with an average age of 29. Of these, 6,706 (68%) of people on ART had viral load suppression. The univaried analysis showed that women were (22%) more likely to have VL suppression (p-value < 0.001) moreover, the chance for all HIV-positive people on treatment to achieve viral load suppression was related to the length of treatment. The results of this study show viral load suppression greater than 68%. The length of antiretroviral therapy, female gender, and advancing age of PLHIV were associated with VL suppression. Targeted awareness raising actions must be undertaken with patients who have an important risk.

Published in Central African Journal of Public Health (Volume 8, Issue 2)
DOI 10.11648/j.cajph.20220802.11
Page(s) 22-27
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Factors Associated, Virological Suppression, Antiretroviral Therapy, Conakry, Guinee

References
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Cite This Article
  • APA Style

    Alimou Camara, Penda Maladho Diallo, Mamadou Bobo Diallo, Talla Nioké, Adama Cissé, et al. (2022). Factors Associated with Virological Suppression of HIV Viral Load in Patients on Antiretroviral Therapy in Conakry, Guinea. Central African Journal of Public Health, 8(2), 22-27. https://doi.org/10.11648/j.cajph.20220802.11

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    ACS Style

    Alimou Camara; Penda Maladho Diallo; Mamadou Bobo Diallo; Talla Nioké; Adama Cissé, et al. Factors Associated with Virological Suppression of HIV Viral Load in Patients on Antiretroviral Therapy in Conakry, Guinea. Cent. Afr. J. Public Health 2022, 8(2), 22-27. doi: 10.11648/j.cajph.20220802.11

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    AMA Style

    Alimou Camara, Penda Maladho Diallo, Mamadou Bobo Diallo, Talla Nioké, Adama Cissé, et al. Factors Associated with Virological Suppression of HIV Viral Load in Patients on Antiretroviral Therapy in Conakry, Guinea. Cent Afr J Public Health. 2022;8(2):22-27. doi: 10.11648/j.cajph.20220802.11

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  • @article{10.11648/j.cajph.20220802.11,
      author = {Alimou Camara and Penda Maladho Diallo and Mamadou Bobo Diallo and Talla Nioké and Adama Cissé and Mamadou Alpha Sylla and Gobounet Lamah and Mamady Diakité and Amadou Sadio Bah and Mamadou Bhoye Keita and Keita Alpha Kabinet Keita and Mamoudou Condé and Kaba Kourouma and Robert Camara and Youssouf Koita and Magassouba Fodé Bangaly and Alioune Camara and Abdoulaye Touré},
      title = {Factors Associated with Virological Suppression of HIV Viral Load in Patients on Antiretroviral Therapy in Conakry, Guinea},
      journal = {Central African Journal of Public Health},
      volume = {8},
      number = {2},
      pages = {22-27},
      doi = {10.11648/j.cajph.20220802.11},
      url = {https://doi.org/10.11648/j.cajph.20220802.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20220802.11},
      abstract = {Viral load testing is a key indicator for assessing ART success and diagnosing drug resistance in people living with HIV/AIDS on antiretroviral therapy. This study aimed to assess virological suppression among people living with HIV / AIDS on antiretroviral therapy in Guinea. This was a three years descriptive cross-sectional that involved adult HIV-positive patients treated in different sites in Conakry. The study population consisted of patients living with HIV/AIDS, followed up at Conakry ART care and treatment sites, samples collected from the study population were sent to the National Institute of Public Health for viral load testing between January 2018 and June 2021. The viral load was quantified by the Generic Biocentric technique and the detection threshold set at 350 copies/ml. Factors associated with virological suppression were analysed by univariate or multivariate logistic regression. Statistical analysis were performed by R software version R4.0.3. A total of 9815 samples were collected and viral load data analyzed at the national public health laboratory. The sample was dominated by women (72%), with an average age of 29. Of these, 6,706 (68%) of people on ART had viral load suppression. The univaried analysis showed that women were (22%) more likely to have VL suppression (p-value < 0.001) moreover, the chance for all HIV-positive people on treatment to achieve viral load suppression was related to the length of treatment. The results of this study show viral load suppression greater than 68%. The length of antiretroviral therapy, female gender, and advancing age of PLHIV were associated with VL suppression. Targeted awareness raising actions must be undertaken with patients who have an important risk.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Factors Associated with Virological Suppression of HIV Viral Load in Patients on Antiretroviral Therapy in Conakry, Guinea
    AU  - Alimou Camara
    AU  - Penda Maladho Diallo
    AU  - Mamadou Bobo Diallo
    AU  - Talla Nioké
    AU  - Adama Cissé
    AU  - Mamadou Alpha Sylla
    AU  - Gobounet Lamah
    AU  - Mamady Diakité
    AU  - Amadou Sadio Bah
    AU  - Mamadou Bhoye Keita
    AU  - Keita Alpha Kabinet Keita
    AU  - Mamoudou Condé
    AU  - Kaba Kourouma
    AU  - Robert Camara
    AU  - Youssouf Koita
    AU  - Magassouba Fodé Bangaly
    AU  - Alioune Camara
    AU  - Abdoulaye Touré
    Y1  - 2022/03/03
    PY  - 2022
    N1  - https://doi.org/10.11648/j.cajph.20220802.11
    DO  - 10.11648/j.cajph.20220802.11
    T2  - Central African Journal of Public Health
    JF  - Central African Journal of Public Health
    JO  - Central African Journal of Public Health
    SP  - 22
    EP  - 27
    PB  - Science Publishing Group
    SN  - 2575-5781
    UR  - https://doi.org/10.11648/j.cajph.20220802.11
    AB  - Viral load testing is a key indicator for assessing ART success and diagnosing drug resistance in people living with HIV/AIDS on antiretroviral therapy. This study aimed to assess virological suppression among people living with HIV / AIDS on antiretroviral therapy in Guinea. This was a three years descriptive cross-sectional that involved adult HIV-positive patients treated in different sites in Conakry. The study population consisted of patients living with HIV/AIDS, followed up at Conakry ART care and treatment sites, samples collected from the study population were sent to the National Institute of Public Health for viral load testing between January 2018 and June 2021. The viral load was quantified by the Generic Biocentric technique and the detection threshold set at 350 copies/ml. Factors associated with virological suppression were analysed by univariate or multivariate logistic regression. Statistical analysis were performed by R software version R4.0.3. A total of 9815 samples were collected and viral load data analyzed at the national public health laboratory. The sample was dominated by women (72%), with an average age of 29. Of these, 6,706 (68%) of people on ART had viral load suppression. The univaried analysis showed that women were (22%) more likely to have VL suppression (p-value < 0.001) moreover, the chance for all HIV-positive people on treatment to achieve viral load suppression was related to the length of treatment. The results of this study show viral load suppression greater than 68%. The length of antiretroviral therapy, female gender, and advancing age of PLHIV were associated with VL suppression. Targeted awareness raising actions must be undertaken with patients who have an important risk.
    VL  - 8
    IS  - 2
    ER  - 

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Author Information
  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Coordination Against AIDS and Hepatitis, Ministry of Health, Conakry, Guinea

  • Department of Pharmaceutical and Biological Sciences, Faculty of Health Sciences and Techniques (FSTS), Gamal Abdel Nasser University of Conakry, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

  • National Institute of Public Health, Ministry of Health, Conakry, Guinea

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