Abstract: Background: Upper Gastrointestinal endoscopy is a safe procedure, and widely available technique for investigation of upper GI conditions. The demand for the investigation continues resulting in an increase number of endoscopic procedures. This observation little information is available in BMC regarding the profile of patients attending for endoscopic examination. The study aim to determine the endoscopic and clinicopathological patterns of upper GI tract conditions and establish agreement between biopsied endoscopic findings and histopathological findings of upper GI tract conditions among patients attending BMC. Methodology: This was a cross-sectional study involving patients with upper gastrointestinal tract conditions receiving endoscopic examination with or without biopsy at BMC between January and May 2020. Recruitment of patient based on serial technique and endoscopic examination done under short sedation. Biopsy were taken on the same sit in eligible patient and preserved in 10% formalin for further histology evaluation. Results: Total of 150 participants were included in the study,139 (92.7%) were attended from outpatient clinics and 11 (7.3%) from inpatients. The median age was 50[IQR 34-65] years. Dyspepsia was the leading clinical presentation 87 (58.0%). In the study population, 141 (94.0%) had abnormal endoscopic findings. Gastritis was the leading finding in both endoscopic and histopathological finding with 41(29.1%) and 36(32.1%). Among patients with abnormal histopathological findings, 23 were esophageal malignancies, 10 gastric malignancies, and 1 duodenal malignancy. The Kappa value 0.778 considered a substantial agreement between endoscopic findings and histopathological findings where K value interpreted as <0.4 as fair, 0.4 to 0.6 as moderate, 0.6 to 0.8 substantial and >0.8 near perfect. Conclusion: Dyspepsia was the commonest clinical presentation among the study participants while gastritis was the leading finding on both endoscopic and histopathological results, followed by esophageal and gastric malignancy. There is substantial agreement between endoscopic and histopathological findings; therefore endoscopy is incomplete without biopsy and histopathology as the gold standard for the diagnosis of upper gastrointestinal conditions.Abstract: Background: Upper Gastrointestinal endoscopy is a safe procedure, and widely available technique for investigation of upper GI conditions. The demand for the investigation continues resulting in an increase number of endoscopic procedures. This observation little information is available in BMC regarding the profile of patients attending for endosc...Show More