Abstract: When it comes to dispensing medicines to children, the use of a suspension agent is sometimes necessary. To ensure that children and adolescents have timely access to safe and effective medicines, including paediatric formulations. The overall objective of this work was to develop an oral paediatric dispensing solution representing the vehicle for suspensions. The specific objectives were to formulate different suspension agents and to determine the physico-chemical characteristics of the paediatric oral suspensions formulated. The suspension preparation method is based on dissolution/dispersion to produce different formulations. Parameters such as pH, viscosity and PA release were determined. The oral suspensions obtained are pleasant and well tolerated, providing precision and consistency, and maintaining physical integrity throughout their shelf life. The pH of the preparations (1 to 6) has an average value of between 3.4 and 3.6. In terms of viscosity, by comparison, Ora Blend® has a higher viscosity than the preparations (1 to 6). The study of the release of sildenafil incorporated in Ora Blend shows that there is very little release in (SGF). In contrast, in (SIF), there is a release from 5 minutes, which increases to 60% after 60 minutes. Omeprazole incorporated into Ora Blend begins to release from 40 minutes in the SGF, and from the first few minutes in the SIF. These results contribute to the advancement of work on the formulation of oral suspension vehicles by providing in-depth knowledge and experimental results. These advances will stimulate innovation in the formulation and administration of paediatric medicines, thereby helping to improve patient care.
Abstract: When it comes to dispensing medicines to children, the use of a suspension agent is sometimes necessary. To ensure that children and adolescents have timely access to safe and effective medicines, including paediatric formulations. The overall objective of this work was to develop an oral paediatric dispensing solution representing the vehicle for ...Show More