Research Article
Research Progress on the Application of Autogenous Demineralized Dentin Matrix Particles for the Regeneration in Periodontitis Alveolar Defect
Li Peng*,
Xiao Xin,
Zhang Huanbin,
Song Jing,
Wang Yuzhe,
Zhong Xiaojun,
Xu Beibei
Issue:
Volume 13, Issue 1, February 2025
Pages:
1-5
Received:
13 February 2025
Accepted:
26 February 2025
Published:
18 March 2025
DOI:
10.11648/j.sd.20251301.11
Downloads:
Views:
Abstract: Demineralized Dentin Matrix (DDM) is derived from discarded human teeth and has a micro-nano structure with porous network. Its dentinal tubules are rich in various enzymes, antimicrobial peptides, and cytokines such as BMP, IGFs, TGF - β, VEGF, IGF, etc., which can guide various cells in the alveolar fossa to grow into the extraction socket and form new bone, which is used for the reconstruction of periodontal bone defects. DDM particles have the advantages of wide source, no immune rejection, simple production process, and low cost. As a new ideal bone material, it is expected to become a substitute for traditional materials on bone transplantation. In this paper, different methods and strategies for the regeneration of alveolar bone defects were summarized, such as bone replacement materials combined with barrier membrane, autologous blood clot, blood derivatives such as PRF and CGF, and other novel biological materials. Then, the physicochemical and biological properties of DDM granules, the improved manufacturing process and the research status of the regeneration of alveolar bone defects caused by periodontitis were reviewed. Finally, the limitations of DDM application and the future direction for DDM development were proposed, in order to expect more evidence-based medical evidence for the clinical application of DDM.
Abstract: Demineralized Dentin Matrix (DDM) is derived from discarded human teeth and has a micro-nano structure with porous network. Its dentinal tubules are rich in various enzymes, antimicrobial peptides, and cytokines such as BMP, IGFs, TGF - β, VEGF, IGF, etc., which can guide various cells in the alveolar fossa to grow into the extraction socket and fo...
Show More
Research Article
Numerical Simulation of the Impact of High-Velocity Ocean Currents on CO2 Leakage in Shallow Saline Aquifers
Issue:
Volume 13, Issue 1, February 2025
Pages:
6-15
Received:
22 February 2025
Accepted:
13 March 2025
Published:
21 March 2025
DOI:
10.11648/j.sd.20251301.12
Downloads:
Views:
Abstract: Offshore CO2 storage in shallow saline aquifers presents significant potential due to its operational feasibility and large storage capacity. However, the natural or anthropogenic damage to the caprock integrity may trigger submarine CO2 leakage. High-velocity ocean currents accelerate the dissolution and dispersion of leaked CO2 in seawater, while current understanding in this field remains limited. This study establishes a seawater-CO2 dissolution-dispersion numerical model based on shallow marine environments, in order to quantify how high-velocity currents affect CO2 dispersion paths and the trend of concentration variations. Simulations reveal that at typical leakage rates (17.0-60.0 kg/day), high-velocity currents (0.20-0.405 m/s) expand the horizontal spread of dissolved CO2 at different water depths by up to 45 m within 2 minutes, approximately 9 times wider than low-velocity situations (0.05 m/s). Simultaneously, rapid dilution occurs: while the peak concentration of CO2 bubbles in high-velocity currents exhibit 1.37 times higher than low-velocity scenarios, dissolved CO2 concentration stabilizes at merely 24.80% of the latter. The results indicate that high-velocity currents complicate the monitoring efforts of CO2 leakage. These findings provide critical insights for predicting impacts of CO2 leakage and optimizing monitoring strategies in shallow marine CO2 storage projects.
Abstract: Offshore CO2 storage in shallow saline aquifers presents significant potential due to its operational feasibility and large storage capacity. However, the natural or anthropogenic damage to the caprock integrity may trigger submarine CO2 leakage. High-velocity ocean currents accelerate the dissolution and dispersion of leaked CO2 in seawater, while...
Show More
