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The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic

Received: 23 April 2021     Accepted: 13 May 2021     Published: 16 September 2022
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Abstract

Relevance: Currently, COVID-19 is considered as a systemic disease with impaired immune system function, primarily affecting the lungs, as well as the heart, kidneys, and intestines. The nature of changes in liver function in (COVID-19) is still poorly understood and poorly covered in the available literature. There are no publications on the nature of liver and gastrointestinal tract damage in patients with end-stage chronic kidney disease with COVID-19 virus infection complicated by pneumonia, in the available modern literature. Purpose of the work: To assess the structure of liver pathology in patients with end-stage chronic renal failure (CRF), including chronically receiving hemofiltration procedures, hospitalized with a diagnosis of COVID-19 in a converted emergency hospital in Moscow. Material and methods: We studied 72 patients, including 38 men and 34 women aged 23-86 years, with an average of 58.2±4.8, who were admitted to the hospital for diagnosis and treatment in the period from 10.04.2020 to 02.10.2020 with diagnoses according to ICD-10: U07.1 Coronavirus infection caused by the COVID-19 virus. All patients underwent ultrasound examination of the liver, gallbladder, pancreas and spleen. The level of liver enzyme activity in dynamics, serum albumin concentration, prothrombin time and index were evaluated. Results: Biochemical signs of liver cell cytolysis were detected in 25-57% of patients with viral pneumonia in COVID-19, which complicates the course of terminal forms of chronic kidney disease with hemodialysis. Most often, the disease was accompanied by signs of a decrease in the synthesis of hemostatic proteins of the prothrombin complex and serum albumin, which may be associated with an aggravation of the severity of their existing chronic anemia. hematomegaly and changes in the liver structure were diagnosed in 42-85% of patients with this pathology and were combined with ultrasoundsigns of damage to the pancreas and spleen in 26-38%. In 11-19% of patients with COVID-19 infection, chronic liver damage preceded the development of pneumonia. Regardless of the state of renal function, these changes were accompanied by a worsening of the course of pre-existing liver and pancreatic lesions, including hepatitis and pancreatitis. Conclusion: Assessment of the state of enzyme and protein-producing function of the liver and pancreas should be included in the standards of inpatient examination in patients with end-stage renal failure and hemodialysis, with the development of COVID-19 and viral pneumonia, due to the high prevalence of liver, gallbladder and pancreas pathology.

Published in World Journal of Public Health (Volume 7, Issue 3)
DOI 10.11648/j.wjph.20220703.16
Page(s) 132-140
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

COVID-19, Viral Pneumonia, End-Stage Chronic Kidney Disease, Liver Damage, Pancreas

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    Vechorko Valery Ivanovich, Evgeny Mikhailovich Evsikov, Teplova Natalya Vadimovna. (2022). The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic. World Journal of Public Health, 7(3), 132-140. https://doi.org/10.11648/j.wjph.20220703.16

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    ACS Style

    Vechorko Valery Ivanovich; Evgeny Mikhailovich Evsikov; Teplova Natalya Vadimovna. The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic. World J. Public Health 2022, 7(3), 132-140. doi: 10.11648/j.wjph.20220703.16

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    AMA Style

    Vechorko Valery Ivanovich, Evgeny Mikhailovich Evsikov, Teplova Natalya Vadimovna. The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic. World J Public Health. 2022;7(3):132-140. doi: 10.11648/j.wjph.20220703.16

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  • @article{10.11648/j.wjph.20220703.16,
      author = {Vechorko Valery Ivanovich and Evgeny Mikhailovich Evsikov and Teplova Natalya Vadimovna},
      title = {The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic},
      journal = {World Journal of Public Health},
      volume = {7},
      number = {3},
      pages = {132-140},
      doi = {10.11648/j.wjph.20220703.16},
      url = {https://doi.org/10.11648/j.wjph.20220703.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20220703.16},
      abstract = {Relevance: Currently, COVID-19 is considered as a systemic disease with impaired immune system function, primarily affecting the lungs, as well as the heart, kidneys, and intestines. The nature of changes in liver function in (COVID-19) is still poorly understood and poorly covered in the available literature. There are no publications on the nature of liver and gastrointestinal tract damage in patients with end-stage chronic kidney disease with COVID-19 virus infection complicated by pneumonia, in the available modern literature. Purpose of the work: To assess the structure of liver pathology in patients with end-stage chronic renal failure (CRF), including chronically receiving hemofiltration procedures, hospitalized with a diagnosis of COVID-19 in a converted emergency hospital in Moscow. Material and methods: We studied 72 patients, including 38 men and 34 women aged 23-86 years, with an average of 58.2±4.8, who were admitted to the hospital for diagnosis and treatment in the period from 10.04.2020 to 02.10.2020 with diagnoses according to ICD-10: U07.1 Coronavirus infection caused by the COVID-19 virus. All patients underwent ultrasound examination of the liver, gallbladder, pancreas and spleen. The level of liver enzyme activity in dynamics, serum albumin concentration, prothrombin time and index were evaluated. Results: Biochemical signs of liver cell cytolysis were detected in 25-57% of patients with viral pneumonia in COVID-19, which complicates the course of terminal forms of chronic kidney disease with hemodialysis. Most often, the disease was accompanied by signs of a decrease in the synthesis of hemostatic proteins of the prothrombin complex and serum albumin, which may be associated with an aggravation of the severity of their existing chronic anemia. hematomegaly and changes in the liver structure were diagnosed in 42-85% of patients with this pathology and were combined with ultrasoundsigns of damage to the pancreas and spleen in 26-38%. In 11-19% of patients with COVID-19 infection, chronic liver damage preceded the development of pneumonia. Regardless of the state of renal function, these changes were accompanied by a worsening of the course of pre-existing liver and pancreatic lesions, including hepatitis and pancreatitis. Conclusion: Assessment of the state of enzyme and protein-producing function of the liver and pancreas should be included in the standards of inpatient examination in patients with end-stage renal failure and hemodialysis, with the development of COVID-19 and viral pneumonia, due to the high prevalence of liver, gallbladder and pancreas pathology.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - The Nature of Changes in Liver Function and Structure in Patients with COVID-19 and End-Stage Chronic Renal Failure Treated at a Repurposed Moscow Clinic
    AU  - Vechorko Valery Ivanovich
    AU  - Evgeny Mikhailovich Evsikov
    AU  - Teplova Natalya Vadimovna
    Y1  - 2022/09/16
    PY  - 2022
    N1  - https://doi.org/10.11648/j.wjph.20220703.16
    DO  - 10.11648/j.wjph.20220703.16
    T2  - World Journal of Public Health
    JF  - World Journal of Public Health
    JO  - World Journal of Public Health
    SP  - 132
    EP  - 140
    PB  - Science Publishing Group
    SN  - 2637-6059
    UR  - https://doi.org/10.11648/j.wjph.20220703.16
    AB  - Relevance: Currently, COVID-19 is considered as a systemic disease with impaired immune system function, primarily affecting the lungs, as well as the heart, kidneys, and intestines. The nature of changes in liver function in (COVID-19) is still poorly understood and poorly covered in the available literature. There are no publications on the nature of liver and gastrointestinal tract damage in patients with end-stage chronic kidney disease with COVID-19 virus infection complicated by pneumonia, in the available modern literature. Purpose of the work: To assess the structure of liver pathology in patients with end-stage chronic renal failure (CRF), including chronically receiving hemofiltration procedures, hospitalized with a diagnosis of COVID-19 in a converted emergency hospital in Moscow. Material and methods: We studied 72 patients, including 38 men and 34 women aged 23-86 years, with an average of 58.2±4.8, who were admitted to the hospital for diagnosis and treatment in the period from 10.04.2020 to 02.10.2020 with diagnoses according to ICD-10: U07.1 Coronavirus infection caused by the COVID-19 virus. All patients underwent ultrasound examination of the liver, gallbladder, pancreas and spleen. The level of liver enzyme activity in dynamics, serum albumin concentration, prothrombin time and index were evaluated. Results: Biochemical signs of liver cell cytolysis were detected in 25-57% of patients with viral pneumonia in COVID-19, which complicates the course of terminal forms of chronic kidney disease with hemodialysis. Most often, the disease was accompanied by signs of a decrease in the synthesis of hemostatic proteins of the prothrombin complex and serum albumin, which may be associated with an aggravation of the severity of their existing chronic anemia. hematomegaly and changes in the liver structure were diagnosed in 42-85% of patients with this pathology and were combined with ultrasoundsigns of damage to the pancreas and spleen in 26-38%. In 11-19% of patients with COVID-19 infection, chronic liver damage preceded the development of pneumonia. Regardless of the state of renal function, these changes were accompanied by a worsening of the course of pre-existing liver and pancreatic lesions, including hepatitis and pancreatitis. Conclusion: Assessment of the state of enzyme and protein-producing function of the liver and pancreas should be included in the standards of inpatient examination in patients with end-stage renal failure and hemodialysis, with the development of COVID-19 and viral pneumonia, due to the high prevalence of liver, gallbladder and pancreas pathology.
    VL  - 7
    IS  - 3
    ER  - 

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Author Information
  • Department of Health, City Clinical Hospital No. 15 Named After Them Oleg Michailovisch Filatov, Moscow, Russia

  • Department of Health, City Clinical Hospital No. 15 Named After Them Oleg Michailovisch Filatov, Moscow, Russia

  • Russian National Research Medical University Named After Them Nikolay Ivanovisch Pirogova, Moscow, Russia

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