3-Butyl-1-methyl-1H-imidazol-3-iumbis((trifluoromethyl)sulfonyl)amide [Bmim][Tf2N] as an environmental-friendly solvent was added to the reaction media for synthesis of some new azole compounds as antifungal agents. The effect of [Bmim][Tf2N] on the rate of reactions was studied using NMR analysis. The results show remarkable increasing in the progress of the reactions. As in recent years the developments of resistance to currently available antifungal azoles in Candida spp., as well as clinical failures in the treatment of fungal infections have been reported therefore intense efforts in antifungal drug discovery are still needed to develop more promising and effective antifungal agents for use in the clinical arena. We present a synthetic route for producing antifungal that is improved by using an ionic liquid.
| Published in | Science Research (Volume 2, Issue 5) |
| DOI | 10.11648/j.sr.20140205.18 |
| Page(s) | 125-131 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Synthesis, Ionic Liquid, NMR, Antifungal
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APA Style
Soghra Khabnadideh, Jason B. Harper. (2014). Effect of an Ionic Liquid [Bmim][Tf2N] on the Rate of Reaction in the Synthesis of some Azole Compounds as Antifungal Agents. Science Research, 2(5), 125-131. https://doi.org/10.11648/j.sr.20140205.18
ACS Style
Soghra Khabnadideh; Jason B. Harper. Effect of an Ionic Liquid [Bmim][Tf2N] on the Rate of Reaction in the Synthesis of some Azole Compounds as Antifungal Agents. Sci. Res. 2014, 2(5), 125-131. doi: 10.11648/j.sr.20140205.18
AMA Style
Soghra Khabnadideh, Jason B. Harper. Effect of an Ionic Liquid [Bmim][Tf2N] on the Rate of Reaction in the Synthesis of some Azole Compounds as Antifungal Agents. Sci Res. 2014;2(5):125-131. doi: 10.11648/j.sr.20140205.18
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Download@article{10.11648/j.sr.20140205.18,
author = {Soghra Khabnadideh and Jason B. Harper},
title = {Effect of an Ionic Liquid [Bmim][Tf2N] on the Rate of Reaction in the Synthesis of some Azole Compounds as Antifungal Agents},
journal = {Science Research},
volume = {2},
number = {5},
pages = {125-131},
doi = {10.11648/j.sr.20140205.18},
url = {https://doi.org/10.11648/j.sr.20140205.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sr.20140205.18},
abstract = {3-Butyl-1-methyl-1H-imidazol-3-iumbis((trifluoromethyl)sulfonyl)amide [Bmim][Tf2N] as an environmental-friendly solvent was added to the reaction media for synthesis of some new azole compounds as antifungal agents. The effect of [Bmim][Tf2N] on the rate of reactions was studied using NMR analysis. The results show remarkable increasing in the progress of the reactions. As in recent years the developments of resistance to currently available antifungal azoles in Candida spp., as well as clinical failures in the treatment of fungal infections have been reported therefore intense efforts in antifungal drug discovery are still needed to develop more promising and effective antifungal agents for use in the clinical arena. We present a synthetic route for producing antifungal that is improved by using an ionic liquid.},
year = {2014}
}
TY - JOUR T1 - Effect of an Ionic Liquid [Bmim][Tf2N] on the Rate of Reaction in the Synthesis of some Azole Compounds as Antifungal Agents AU - Soghra Khabnadideh AU - Jason B. Harper Y1 - 2014/10/30 PY - 2014 N1 - https://doi.org/10.11648/j.sr.20140205.18 DO - 10.11648/j.sr.20140205.18 T2 - Science Research JF - Science Research JO - Science Research SP - 125 EP - 131 PB - Science Publishing Group SN - 2329-0927 UR - https://doi.org/10.11648/j.sr.20140205.18 AB - 3-Butyl-1-methyl-1H-imidazol-3-iumbis((trifluoromethyl)sulfonyl)amide [Bmim][Tf2N] as an environmental-friendly solvent was added to the reaction media for synthesis of some new azole compounds as antifungal agents. The effect of [Bmim][Tf2N] on the rate of reactions was studied using NMR analysis. The results show remarkable increasing in the progress of the reactions. As in recent years the developments of resistance to currently available antifungal azoles in Candida spp., as well as clinical failures in the treatment of fungal infections have been reported therefore intense efforts in antifungal drug discovery are still needed to develop more promising and effective antifungal agents for use in the clinical arena. We present a synthetic route for producing antifungal that is improved by using an ionic liquid. VL - 2 IS - 5 ER -
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