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Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat

Received: 19 January 2023     Accepted: 14 February 2023     Published: 11 April 2023
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Abstract

Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the gastroprotective activity of Boswelia dalzielii. The cytoprotective property of Boswelia dalzielii was evaluated by using five experimental methods of GU: 1. Absolute ethanol, 2. HCl/Ethanol, 3. HCl/ Ethanol/ Indomethacin, 4. Indomethacin, 5. Pylorus ligation. Omeprazole was used as reference anti-ulcer drugs. Phytochemical screening of Boswelia dalzielii was carried out, and experimental Wistar rats (150-200 g) were used to evaluate the anti-ulcerogenic effects of the extract was carried out. Phytochemical screening of the effects of extract of Boswelia dalzielii extract revealed the presence of phytochemicals components such as tannins, saponins, flavonoids, triterpenes, and phenols. The oral administrations of 400 mg/kg of body weight of Boswelia dalzielii could protect the gastric mucosa against gastric ulcer. The results showed that Boswelia dalzielii at a concentration of 400 mg/kg has significant antiulcerogenic effects against absolute ethanol, hydrochloride ethanol (HCl/EtOH), HCl/ EtOH/IND, and pyloric ligation-induced gastric ulcer.

Published in Journal of Diseases and Medicinal Plants (Volume 9, Issue 2)
DOI 10.11648/j.jdmp.20230902.11
Page(s) 33-39
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Medicinal Plant, Gastric Ulcer, Gastroprotection, Pyloric Ligation

References
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Cite This Article
  • APA Style

    Gustave Lebeau Ndji Otto, Adjia Hamadjida, Joel Hermann Taguemkam Sando, Loraine Sandrine Wega Youdom, Ludice Isabelle Golda Djouana Malefaa, et al. (2023). Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat. Journal of Diseases and Medicinal Plants, 9(2), 33-39. https://doi.org/10.11648/j.jdmp.20230902.11

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    ACS Style

    Gustave Lebeau Ndji Otto; Adjia Hamadjida; Joel Hermann Taguemkam Sando; Loraine Sandrine Wega Youdom; Ludice Isabelle Golda Djouana Malefaa, et al. Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat. J. Dis. Med. Plants 2023, 9(2), 33-39. doi: 10.11648/j.jdmp.20230902.11

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    AMA Style

    Gustave Lebeau Ndji Otto, Adjia Hamadjida, Joel Hermann Taguemkam Sando, Loraine Sandrine Wega Youdom, Ludice Isabelle Golda Djouana Malefaa, et al. Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat. J Dis Med Plants. 2023;9(2):33-39. doi: 10.11648/j.jdmp.20230902.11

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  • @article{10.11648/j.jdmp.20230902.11,
      author = {Gustave Lebeau Ndji Otto and Adjia Hamadjida and Joel Hermann Taguemkam Sando and Loraine Sandrine Wega Youdom and Ludice Isabelle Golda Djouana Malefaa and Amang André Perfusion and Désirée Sandrine Essama Mbida and Jean Pierre Kilekoung Mingoas and Ernestine Nkwengoua Zodengoumba and Tan Paul Vernyuy},
      title = {Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat},
      journal = {Journal of Diseases and Medicinal Plants},
      volume = {9},
      number = {2},
      pages = {33-39},
      doi = {10.11648/j.jdmp.20230902.11},
      url = {https://doi.org/10.11648/j.jdmp.20230902.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20230902.11},
      abstract = {Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the gastroprotective activity of Boswelia dalzielii. The cytoprotective property of Boswelia dalzielii was evaluated by using five experimental methods of GU: 1. Absolute ethanol, 2. HCl/Ethanol, 3. HCl/ Ethanol/ Indomethacin, 4. Indomethacin, 5. Pylorus ligation. Omeprazole was used as reference anti-ulcer drugs. Phytochemical screening of Boswelia dalzielii was carried out, and experimental Wistar rats (150-200 g) were used to evaluate the anti-ulcerogenic effects of the extract was carried out. Phytochemical screening of the effects of extract of Boswelia dalzielii extract revealed the presence of phytochemicals components such as tannins, saponins, flavonoids, triterpenes, and phenols. The oral administrations of 400 mg/kg of body weight of Boswelia dalzielii could protect the gastric mucosa against gastric ulcer. The results showed that Boswelia dalzielii at a concentration of 400 mg/kg has significant antiulcerogenic effects against absolute ethanol, hydrochloride ethanol (HCl/EtOH), HCl/ EtOH/IND, and pyloric ligation-induced gastric ulcer.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Gastroprotective Activity and Potential Mechanism of the Stem Bark of Boswellia dalzielii on Gastric Ulcer in Rat
    AU  - Gustave Lebeau Ndji Otto
    AU  - Adjia Hamadjida
    AU  - Joel Hermann Taguemkam Sando
    AU  - Loraine Sandrine Wega Youdom
    AU  - Ludice Isabelle Golda Djouana Malefaa
    AU  - Amang André Perfusion
    AU  - Désirée Sandrine Essama Mbida
    AU  - Jean Pierre Kilekoung Mingoas
    AU  - Ernestine Nkwengoua Zodengoumba
    AU  - Tan Paul Vernyuy
    Y1  - 2023/04/11
    PY  - 2023
    N1  - https://doi.org/10.11648/j.jdmp.20230902.11
    DO  - 10.11648/j.jdmp.20230902.11
    T2  - Journal of Diseases and Medicinal Plants
    JF  - Journal of Diseases and Medicinal Plants
    JO  - Journal of Diseases and Medicinal Plants
    SP  - 33
    EP  - 39
    PB  - Science Publishing Group
    SN  - 2469-8210
    UR  - https://doi.org/10.11648/j.jdmp.20230902.11
    AB  - Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the gastroprotective activity of Boswelia dalzielii. The cytoprotective property of Boswelia dalzielii was evaluated by using five experimental methods of GU: 1. Absolute ethanol, 2. HCl/Ethanol, 3. HCl/ Ethanol/ Indomethacin, 4. Indomethacin, 5. Pylorus ligation. Omeprazole was used as reference anti-ulcer drugs. Phytochemical screening of Boswelia dalzielii was carried out, and experimental Wistar rats (150-200 g) were used to evaluate the anti-ulcerogenic effects of the extract was carried out. Phytochemical screening of the effects of extract of Boswelia dalzielii extract revealed the presence of phytochemicals components such as tannins, saponins, flavonoids, triterpenes, and phenols. The oral administrations of 400 mg/kg of body weight of Boswelia dalzielii could protect the gastric mucosa against gastric ulcer. The results showed that Boswelia dalzielii at a concentration of 400 mg/kg has significant antiulcerogenic effects against absolute ethanol, hydrochloride ethanol (HCl/EtOH), HCl/ EtOH/IND, and pyloric ligation-induced gastric ulcer.
    VL  - 9
    IS  - 2
    ER  - 

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Author Information
  • Department of Life Science, Higher Teachers’ Training College, University of Bertoua, Bertoua, Cameroon

  • Department of Life Science, Higher Teachers’ Training College, University of Bertoua, Bertoua, Cameroon

  • Department of Life Science, Higher Teachers’ Training College, University of Bertoua, Bertoua, Cameroon

  • Department of Life Science, Higher Teachers’ Training College, University of Bertoua, Bertoua, Cameroon

  • Department of Life Science, Higher Teachers’ Training College, University of Bertoua, Bertoua, Cameroon

  • Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua, Cameroon

  • Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon

  • School of Veterinary Medicine and Sciences, University of Ngaoundere, Ngaoundere, Cameroon

  • Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon

  • Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon

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