Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.
| Published in | International Journal of Pharmacy and Chemistry (Volume 6, Issue 4) |
| DOI | 10.11648/j.ijpc.20200604.11 |
| Page(s) | 37-40 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Peptide Amphiphiles, Tumor Microenvironment, Targeted Delivery, Nanocarriers
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APA Style
Fahimeh Shamsi. (2020). The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. International Journal of Pharmacy and Chemistry, 6(4), 37-40. https://doi.org/10.11648/j.ijpc.20200604.11
ACS Style
Fahimeh Shamsi. The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. Int. J. Pharm. Chem. 2020, 6(4), 37-40. doi: 10.11648/j.ijpc.20200604.11
AMA Style
Fahimeh Shamsi. The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. Int J Pharm Chem. 2020;6(4):37-40. doi: 10.11648/j.ijpc.20200604.11
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Download@article{10.11648/j.ijpc.20200604.11,
author = {Fahimeh Shamsi},
title = {The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors},
journal = {International Journal of Pharmacy and Chemistry},
volume = {6},
number = {4},
pages = {37-40},
doi = {10.11648/j.ijpc.20200604.11},
url = {https://doi.org/10.11648/j.ijpc.20200604.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20200604.11},
abstract = {Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.},
year = {2020}
}
TY - JOUR T1 - The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors AU - Fahimeh Shamsi Y1 - 2020/08/04 PY - 2020 N1 - https://doi.org/10.11648/j.ijpc.20200604.11 DO - 10.11648/j.ijpc.20200604.11 T2 - International Journal of Pharmacy and Chemistry JF - International Journal of Pharmacy and Chemistry JO - International Journal of Pharmacy and Chemistry SP - 37 EP - 40 PB - Science Publishing Group SN - 2575-5749 UR - https://doi.org/10.11648/j.ijpc.20200604.11 AB - Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites. VL - 6 IS - 4 ER -
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