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The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors

Received: 27 June 2020     Accepted: 10 July 2020     Published: 4 August 2020
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Abstract

Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.

Published in International Journal of Pharmacy and Chemistry (Volume 6, Issue 4)
DOI 10.11648/j.ijpc.20200604.11
Page(s) 37-40
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Peptide Amphiphiles, Tumor Microenvironment, Targeted Delivery, Nanocarriers

References
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Cite This Article
  • APA Style

    Fahimeh Shamsi. (2020). The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. International Journal of Pharmacy and Chemistry, 6(4), 37-40. https://doi.org/10.11648/j.ijpc.20200604.11

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    ACS Style

    Fahimeh Shamsi. The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. Int. J. Pharm. Chem. 2020, 6(4), 37-40. doi: 10.11648/j.ijpc.20200604.11

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    AMA Style

    Fahimeh Shamsi. The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. Int J Pharm Chem. 2020;6(4):37-40. doi: 10.11648/j.ijpc.20200604.11

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  • @article{10.11648/j.ijpc.20200604.11,
      author = {Fahimeh Shamsi},
      title = {The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {6},
      number = {4},
      pages = {37-40},
      doi = {10.11648/j.ijpc.20200604.11},
      url = {https://doi.org/10.11648/j.ijpc.20200604.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20200604.11},
      abstract = {Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors
    AU  - Fahimeh Shamsi
    Y1  - 2020/08/04
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ijpc.20200604.11
    DO  - 10.11648/j.ijpc.20200604.11
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 37
    EP  - 40
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20200604.11
    AB  - Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.
    VL  - 6
    IS  - 4
    ER  - 

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Author Information
  • Biotechnology Research Centre, Semnan University of Medical Sciences, Semnan, Iran

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