Browse

Journals By Subject

Life Sciences, Agriculture & Food
Chemistry
Medicine & Health
Materials Science
Mathematics & Physics
Electrical & Computer Science
Earth, Energy & Environment
Architecture & Civil Engineering
Education
Economics & Management
Humanities & Social Sciences
Multidisciplinary

Books

Publish Conference Abstract Books
Upcoming Conference Abstract Books
Published Conference Abstract Books
Publish Your Books
Upcoming Books
Published Books

Proceedings

Events

Events
Five Types of Conference Publications

Join

Join the Editorial Board
Become a Reviewer

Information

For Authors
For Reviewers
For Editors
For Conference Organizers
For Librarians
Article Processing Charges
Special Issue Guidelines
Editorial Process
Manuscript Transfers
Peer Review at SciencePG
Open Access
Copyright and License
Ethical Guidelines
Case Report | | Peer-Reviewed

Multimodal Imaging in Diagnosis of Vogt Koyanagi Harada Disease with Reference to Choroid and Retinal Pigment Epithelium

Deepesh Arora*,  Anuj Sharma,  Devesh Sharma,  Dinesh Sharma
Published in International Journal of Ophthalmology & Visual Science (Volume 9, Issue 2)
Received: 22 April 2024    Accepted: 13 May 2024    Published: 30 May 2024
Views:       Downloads:
Download PDF
Abstract

A 48 year dark skinned North Indian male presented first time to our outpatient with history of bilateral visual decline of 3 weeks duration with associated features of headache, myalgia and rhinitus of 4 weeks duration. A detailed examination confirmed bilateral active anterior granulomatous uveitis with bilateral disc oedema with serous retinal detachment. Multimodal imaging examination was carried out with nideks mirante. Diagnosis in favour of vogt koyanagi harada disease was confirmed. The posterior segment was assessed for various changes in acute and remission phase of vogt koyanagi harada disease with fundus fluorescein angiography, fundus autoflourescence, retroillumination and optical coherence tomography. Thickness and structural change related to central macula thickness, retinal pigment epithelium and choroid were assessed pre and post treatment with additional support of optical coherence tomography and retroillumination. Both these techniques were able to document a greater value change pre and post treatment in these structures. Hence we conclude the need to include these techniques in retinal pigment epithelium and choroidal assessment in vogt koyanagi harada disease.

Published in International Journal of Ophthalmology & Visual Science (Volume 9, Issue 2)
DOI 10.11648/j.ijovs.20240902.12
Page(s) 23-29
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group
Previous article
Keywords

Imaging, VKHD, RPE, Choroid

1. Introduction
Vogt Koyanagi Harada disease (VKHD) is a bilateral granulomatous uveitis which is frequently associated with exudative retinal detachment. Extra-ocular manifestations may form part of disease process presenting as vitiligo, poliosis, alopecia, dysacusis with involvement of cerebrospinal fluid noticed as pleocytosis
[1]
. It commonly affects individuals, in the second to the fifth decade of life, of pigmented races of Asian, Hispanic, American Indian and Asian Indian descent with a female preponderance.
[1-3]
.
The disease is believed to be an auto-immune disorder with a T-cell mediated autoimmune response against the melanocytes, melanin and retinal pigment epithelium (RPE)
[4]
. Recent evidence points towards the utility of the RPE layer as a biomarker for the choroidal activity and inflammation in the acute stage of VKHD
[5]
.
The RPE and the choroid were evaluated in a case of a 48 year old patient diagnosed with VKHD using Fundus Fluorescein Angiography, Optical Coherence Tomography, Fundus Auto-fluoresence and Retro-imaging and found a direct co-relation between the choroidal thickness and RPE reflectivity with the inflammation noted in the disease.
2. Case Report
A 48 year old dark skinned North Indian male presented to us with a history of bilateral visual decline since the past 3 weeks associated with features of headache and myalgia of 4 weeks duration. There was no history of any prior medical or ocular consultation.
Examination revealed a best corrected visual acuity (BCVA) of 6/24 in the right eye (OD) and 6/60 in the left eye (OS) with an intra-ocular pressure of 18mmHg in both eyes. Ocular examination confirmed bilateral granulomatous anterior uveitis with 1 plus cells and flare and mutton fat keratic precipitates (KPs) in both eyes. Posterior segment examination showed vitreous cells 1+ associated with a bilateral disc swelling, serous retinal detachment and presence of bilateral retinal folds extending from disc to macula (Figures 1 and 2). Physical evaluation revealed nuchal rigidity, however there was no evidence of any hypo-pigmented skin lesions or tinnitus.
3. Materials and Methods
A Fundus fluorescein angiography was carried out which revealed blurred optic disc margins depicting leakage, multifocal pin point leaks seen at juxtapapillary and posterior pole (Figures 3 and 4) in the late phase. The periphery showed active leaks from terminal vessels extending to ora serrata (Figures 3 and 4). Fundus auto-flourescence (FAF) distinctively revealed hyper auto-fluorescence at posterior pole of both eyes highlighting RPE (Retinal pigment epithelium) involvement (Figures 5 and 6).
Retro-imaging was carried out which revealed the presence of abnormally elevated leaf pattern area of elevated retina at the posterior pole and radiating fine foveal folds suggesting RPE involvement (Figures 7 and 8).
Optical coherence tomography (Optovue - Spectral domain OCT) showed serous neurosensory detachment divided into multiple compartments by fibrous septa and presence of intra-retinal fluid accumulation appearing as cyst formation (Figures 9 and 10).
Figure 1. Fundus OD shows disc swelling, serous retinal detachment at posterior pole with presence of retinal folds extending from disc to macula.
Figure 2. Fundus OS shows disc odema with multiple pockest of serous retinal detachment involving macula.
Figure 3. Fundus fluorescein angiography OD revealed disc leakage with blurred optic disc margin, multifocal pin point leaks seen at juxtapapillary and posterior pole.
Figure 4. FFA OS periphery shows active leaks from multiple terminal vessels extending to ora.
Figure 5. Fundus auto-flourescence (FAF) OD distinctively revealed hyper auto-fluorescence at posterior pole highlighting RPE (Retinal pigment epithelium) involvement.
Figure 6. Fundus auto-flourescence (FAF) OS revealed hyper auto-fluorescence at posterior pole confirming retinal pigment epithelium involvement.
Figure 7. Retroillumination image of acute VKHD OD shows disc florescence and a large posterior pole leaf pattern area of hypoflourescence suggesting RPE involvement with patchy hyperflourescent areas of unaffected RPE surrounding it.
Figure 8. Retroillumination image of OS with acute VKHD showing detailed disc flourescence with large well demarcated posterior pole hypoflourescent area of RPE involvement surrounded by normal hyperflourescent pigment epithelium.
Figure 9. OCT – Macula OD shows intra-retinal odema, neurosensory detachment (NSD), bacillary layer detachment, subretinal hyperreflective dots, choroidal hyperreflective dots and retinal pigment epithelium vacuolation.
Figure 10. OCT –Macula OS shows bacillary layer detachment, subretinal and choroidal hyperreflective dots more prominent in this eye.
A clinical diagnosis of VKHD was made and intensive topical steroid was started with (prednisolone acetate 1%) 1 hourly application, a mydratic-cycloplegic combination (atropine sulphate 1%) 3 times a day was also initiated for pain relief and also to prevent development of synechiae. Three consecutive doses, over the course of 3 days, of methylprednisolone 1gm/day were administered intravenously in 200 ml of 20% dextrose normal saline (DNS) over 3 hours. This was followed by oral prednisolone tablets (1 mg/kg/body weight) once daily slowly tapered over 3 months to a dose less than 10mg/day.
An immunomodulator namely Mycophenolate Mofetil (MMF) in dosage of 500 mg was started in single application for one week and subsequently increased to three times a day with a strict watch on liver function test. After 3 weeks the BCVA was OD 6/9 and OS 6/12. Posterior pole depicted bilateral hyperaemic disc with pigmentation, 360 degree radiating foveal retinal folds and a large area of pigmentary disturbance at posterior pole with hypereflective outline of resolved subretinal fluid at posterior pole with pigmentary disturbance (Figures 11 and 12). FAF showed disappearance of hyper-autoflourescence at posterior pole to be replaced by hypo-autoflorescence with patchy hyper-autoflourescence at the borders (Figures 13 and 14) (suggestive of RPE disturbance). Retroillumination showed a recovery phase of VKHD depicted by resolution of the area of elevated RPE (Figures 15 and 16). The area of RPE elevation was better demarcated on the Retro-illumination photographs as compared to the colour fundus or the auto-fluoresence images. OCT showed resolution of large cystic spaces, the septae and intraretinal fluid with persistence of bilateral minimal subfoveal subretinal fluid (Figures 17 and 18). Medications were tapered after assessment of disease status involving anterior chamber and posterior segment with strict watch on retino-choroidal presentation. The OCT-macula imaging was utilized to calculate subfoveal choroidal thickness (Table 1) and optic nerve head dimension (Table 2). The retro-imaging was utilized to calculate the change in RPE elevation pre and post treatment (Table 3).
Figure 11. Fundus photo OD 3 weeks into post treatment shows hyperemic disc and radial foveal folds with a large area of RPE at posterior pole involved in acute VKH disease.
Figure 12. Fundus photo OS 3 weeks into post treatment shows a hyperemic disc with radial folds and a well demarcated area of RPE previously involved in acute VKHD seen at posterior pole.
Figure 13. FAF photo OD shows a large leaf like area of hypoflourescence depicting RPE involvement seen at posterior pole.
Figure 14. FAF image OS shows a large posterior pole hypoflourescent area extending outside of superior arcade and involving fovea correlating to poor visual recovery.
Figure 15. Retroillumination image OD shows hyperflourescent posterior pole intersperced with recovering hypoflourescent areas seen adjacent to inferior arcade.
Figure 16. Retroillumination image OS during 3 week recovery phase shows large RPE defect as hypoflourescent patch at posterior pole.
Figure 17. OCT- Macula VKHD early post recovery with presence of subretinal fluid, reduced presence of subretinal and choroidal hyperreflective dots with altered RPE reflectivity.
Figure 18. OCT-Macula OS reveals irregular inner and outer retinal layers with loss of architecture, presence of subretinal fluid, persistence of choroidal hyperreflective dots.
4. Results
The subfoveal choroidal thickness was calculated at the fovea on the OCT machine by drawing a perpendicular line extending downwards from the RPE-Bruchs membrane complex to the outer margin of the choroid as visible on the EDI-OCT. The similar process was repeated for the other eye.
Table 1. Comparison of subfoveal choroidal thickness in the Right and the Left eye prior to and following treatment.

Subfoveal Choroidal Thickness

Right Eye

Left Eye

At Presentation

593 microns

486 microns

After Therapy

430 microns

410 microns
A note was also made of the horizontal and vertical margins of the optic nerve head whose dimensions came out to be as mentioned below. These measurements were later used to calculate the area of the RPE elevation on the retro-imaging.
Table 2. The horizontal and vertical measurements of the optic nerve head in the right and the left eyes.

Right Eye

Left Eye

Horizontal Diameter

1382 microns

1504 microns

Vertical Diameter

1461 microns

1636 microns
The RPE elevation was calculated on en-face retinal imaging by marking the outlines of the elevated RPE on (Image 7 and 8) and calculating the area hence forth. The disc margins were used as reference and the horizontal and vertical diameters calculated as above were used for calculating the area of involvement.
Table 3. Comparison of RPE elevation and NSD in the Right and the Left eye prior to and following treatment.

Right Eye

Left Eye

At Presentation

42.906 mm2

55.443 mm2

After Therapy

14.661 mm2

19.931 mm2
5. Discussion
Optical Coherence Tomography is highly informative imaging tool in documenting changes at level of retinal pigment epithelium and choroid. Our patient showed subfoveal increase in choroidal thickness during acute inflammatory phase of which showed subsequent resolution following immunosuppressive therapy
[6]
. Similar findings with emphasis on recurrence of choroidal thickness have been documented elsewhere postulated by acute disease leading to inflammatory infiltration with increased exudation involving choroid. The outer layers of the choroid are principally involved in VKHD
[7-9]
. The choriocapillaris suffers from metabolic stress and hypoxemia due to insufficient perfusion the disease progresses, this leads to disturbance in its function of providing nutrition, oxygen, ions with water to RPE and outer retina
[10]
.
A single-centre retrospective observational study showed changes in retinal pigment epithelium (RPE) reflectivity immediately above the choroid in eyes with acute VKH disease, as well as the strong association between RPE reflectivity and VKH disease recurrence
[11]
. With subsidence of choroidal inflammation one gets to notice histological change as focal loss of RPE
[12, 13]
. In chronic cases of VKHD, hyperplastic RPE may appear clinically as subretinal fibrosis,
[13]
confirmed on OCT. This is a significant prognostic indicator related to visual acuity in VKHD. A specific change related to melanin accumulation in the RPE at the location of granular hyper near infrared-autoflourescence has been detected by multicontrast-OCT supporting in evaluation of RPE changes in chronic VKHD
[14]
. A similar change visible in convalescent stage shows focal RPE melanin accumulation (FRMA) derived from RPE melanin and sunset glow fundus derived from choroid melanin as visible changes
[15]
. RPE undulations seen in acute stage of VKHD is a predictor of posterior recurrences and poor visual outcomes after high-dose steroid therapy in VKHD
[16]
. Presence of hyper-reflective outer nuclear layer (HROL) is also poor prognostic indicator of thinning and atrophy of outer retinal layers
[17]
.
Bacillary layer detachment (BLD) constitutes a commonly seen feature in eyes with acute stage of VKHD. Defect is seen at the level of photoreceptor layer creating a split at the inner segment myoid
[18]
. Serial swept source OCT has been efficient in detecting changes in acute and recovery phase in both bacillary layer and photoreceptors
[17]
. The role of pulse steroids in re-establishing anatomical and functional integrity and speed of recovery of bacillary layer has been reported elsewhere
[19]
. “Kwak JJ et al” reported that patients with BLD have high recurrence rate requiring more frequent and thorough follow up in comparison to those without BLD
[20]
.
6. Conclusion
The Retinal Pigment Epithelium plays a pivotal role in maintaining the anatomical and functional integrity of the neurosensory retina. In cases of posterior uveitis as seen in Vogt Koyanagi Harada disease, an inflammatory assault is noted in the outer choroidal layers and the RPE which results in both anatomical and physiological changes in the retina. The degree of inflammation directly correlates with the RPE changes and the morphological phenomenon as documented above. Immunosuppressive therapy either with steroids or immunomodulator agents helps in decreasing the inflammatory response and in restoring normalcy in the diseased retina. However, in cases of chronic inflammation this may lead to vision threatening sub-retinal fibrosis and scarring. Hence, accurate assessment of the choroid and the RPE via multimodal imaging helps in prognosticating the disease severity and follow-up.
Abbreviations

VKHD

Vogt Koyanagi Harada Disease

FAF

Fundus Auto-Flourescence

OCT

Optical Coherence Tomography

MMF

Mycophenolate Mofetil

RPE

Retinal Pigment Epithelium

BLD

Bacillary Layer Detachment

HROL

Hyper-Reflective Outer Nuclear Layer
Author Contributions
Deepesh Arora: Writing – review & editing, Writing – original draft
Anuj Sharma: Conceptualization, Investigation, Supervision, Writing – review & editing
Devesh Sharma: Data curation, Formal Analysis, Funding acquisition, Methodology, Resources, Validation, Visualization
Dinesh Sharma: Supervision, Validation, Visualization
Conflicts of Interest
The authors declare no conflicts of interest.
References
[1] Moorthy RS, Inomata H, Rao NA. Vogt–Koyanagi–Harada syndrome. Surv Ophthalmol 1995; 39: 265–92.
[2] Shimizu K. Harada’s, Behçet’s, Vogt–Koyanagi syndromes: are they clinical entities? Trans Am Acad Ophthalmol Otolaryngol 1973; 77: 281–90.
[3] Forster DJ, Green RL, Rao NA. Unilateral manifestation of the Vogt–Koyanagi–Harada syndrome in a 7-year-old child. Am J Ophthalmol 1991; 111: 380–2.
[4] Sugita S, Takase H, Imai Y, et al. Immunopathogenic mechanism of melanocyte-specific autoimmune disease: a cross reaction between tyrosinase peptides and cytomegalovirus antigen. Invest OphthalmolVis Sci. 2002: 43: 1529.
[5] Jacob N, Tyagi M, Chhablani J, Narayanan R, Kelgaonkar A, Jain M, Singh SR et al. Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease. J Clin Med 2023, 12(6), 2638;

https://doi.org/10.3390/jcm12062368

[6] O'Keefe GA, Rao NA. Vogt-Koyanagi-Harada disease. Surv Ophthalmol. 2017 Jan-Feb; 62(1): 1-25.

https://doi.org/10.1016/j.survophthal.2016.05.002 Epub 2016 May 27. PMID: 27241814.

[7] Maruko I, Iida T, Sugano Y, Oyamada H, Sekiryu T, Fujiwara T, Spaide RF. Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease. Retina. 2011 Mar; 31(3): 510-7.

https://doi.org/10.1097/IAE.0b013e3181eef053 PMID: 20948460.

[8] Nakai K, Gomi F, Ikuno Y, Yasuno Y, Nouchi T, Ohguro N, Nishida K. Choroidal observations in Vogt-Koyanagi-Harada disease using high-penetration optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2012 Jul; 250(7): 1089-95.

https://doi.org/10.1007/s00417-011-1910-7 Epub 2012 Jan 13. PMID: 22240936.

[9] Hirooka K, Saito W, Namba K, Mizuuchi K, Iwata D, Hashimoto Y, Ishida S. Significant role of the choroidal outer layer during recovery from choroidal thickening in Vogt-Koyanagi-Harada disease patients treated with systemic corticosteroids. BMC Ophthalmol. 2015 Dec 18; 15: 181.

https://doi.org/10.1186/s12886-015-0171-3 PMID: 26677974; PMCID: PMC4683749.

[10] Spraul CW, Lang GE, Lang GK, Grossniklaus HE. Morphometric changes of the choriocapillaris and the choroidal vasculature in eyes with advanced glaucomatous changes. Vision Res. 2002; 42: 923–32.
[11] Hirota Y, Muraoka Y, Kogo T, Ishikura M, Kadomoto S, Nishigori N, Ishihara K, Morooka S, Uji A, Tsujikawa A. Association of Retinal Pigment Epithelium Reflectivity on Optical Coherence Tomography with Recurrence of Vogt-Koyanagi-Harada Disease: A Retrospective Observational Study. Clin Ophthalmol. 2023 Jul 21; 17: 2071-2079.

https://doi.org/10.2147/OPTH.S419546 PMID: 37496848; PMCID: PMC10368137.

[12] Inomata H, Rao NA. Depigmented atrophic lesions in sunset glow fundi of Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2001 May; 131(5): 607-14.

https://doi.org/10.1016/s0002-9394(00)00851-5 PMID: 11336935.

[13] Rao NA. Pathology of Vogt-Koyanagi-Harada disease. Int Ophthalmol. 2007 Apr-Jun; 27(2-3): 81-5.

https://doi.org/10.1007/s10792-006-9029-2 Epub 2007 Apr 14. PMID: 17435969.

[14] Miura M, Makita S, Azuma S, Yasuno Y, Sugiyama S, Mino T, Yamaguchi T, Agawa T, Iwasaki T, Usui Y, Rao NA, Goto H. Evaluation of Retinal Pigment Epithelium Layer Change in Vogt-Koyanagi-Harada Disease With Multicontrast Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2019 Aug 1; 60(10): 3352-3362.

https://doi.org/10.1167/iovs.19-27378 PMID: 31917451.

[15] Huang Y, Yang YT, Lin B, Huang SH, Sun ZH, Zhou R, Li YZ, Liu XL. Melanin change of retinal pigment epithelium and choroid in the convalescent stage of Vogt-Koyanagi-Harada disease. Int J Ophthalmol. 2020 Dec 18; 13(12): 1928-1932.

https://doi.org/10.18240/ijo.2020.12.13 PMID: 33344192; PMCID: PMC7708368.

[16] Hashizume K, Imamura Y, Fujiwara T, Machida S, Ishida M, Kurosaka D. RETINAL PIGMENT EPITHELIUM UNDULATIONS IN ACUTE STAGE OF VOGT- KOYANAGI-HARADA DISEASE: Biomarker for Functional Outcomes After High-Dose Steroid Therapy. Retina. 2016 Feb; 36(2): 415-21.

https://doi.org/10.1097/IAE.0000000000000728 PMID: 26352553.

[17] Fonollosa A, Charcán I, Giralt L, Artaraz J, Soto A, Ruiz-Arruza I, Agarwal A. Hyper-Reflective Outer Nuclear Layer (HONL) in Vogt-Koyanagi-Harada Disease and Sympathetic Ophthalmia. Ocul Immunol Inflamm. 2022 Nov 4: 1-5.

https://doi.org/10.1080/09273948.2022.2134038 Epub ahead of print. PMID: 36332138.

[18] Agarwal A, Freund KB, Kumar A, Aggarwal K, Sharma D, Katoch D, Bansal R, Gupta V; OCTA Study Group. BACILLARY LAYER DETACHMENT IN ACUTE VOGT-KOYANAGI-HARADA DISEASE: A Novel Swept-Source Optical Coherence Tomography Analysis. Retina. 2021 Apr 1; 41(4): 774-783.

https://doi.org/10.1097/IAE.0000000000002914 PMID: 32833410.

[19] Atas F, Kaya M, Saatci AO. The effect of pulse steroid treatment of ten days' long on the improvement of bacillary layer detachment in a patient with Vogt-Koyanagi Harada disease. Rom J Ophthalmol. 2021 Apr-Jun; 65(2): 183-186.

https://doi.org/10.22336/rjo.2021.36 PMID: 34179585; PMCID: PMC8207875.

[20] Kwak JJ, Lee J, Byeon SH. Clinical Features and Prognostic Value of Bacillary Layer Detachment in Acute Vogt-Koyanagi-Harada Disease. Retina. 2023 Jun 8.

https://doi.org/10.1097/IAE.0000000000003858 Epub ahead of print. PMID: 37315551.

Cite This Article
Plain Text BibTeX RIS

  • APA Style

    Arora, D., Sharma, A., Sharma, D., Sharma, D. (2024). Multimodal Imaging in Diagnosis of Vogt Koyanagi Harada Disease with Reference to Choroid and Retinal Pigment Epithelium. International Journal of Ophthalmology & Visual Science, 9(2), 23-29. https://doi.org/10.11648/j.ijovs.20240902.12

    Copy | Download

    ACS Style

    Arora, D.; Sharma, A.; Sharma, D.; Sharma, D. Multimodal Imaging in Diagnosis of Vogt Koyanagi Harada Disease with Reference to Choroid and Retinal Pigment Epithelium. Int. J. Ophthalmol. Vis. Sci. 2024, 9(2), 23-29. doi: 10.11648/j.ijovs.20240902.12

    Copy | Download

    AMA Style

    Arora D, Sharma A, Sharma D, Sharma D. Multimodal Imaging in Diagnosis of Vogt Koyanagi Harada Disease with Reference to Choroid and Retinal Pigment Epithelium. Int J Ophthalmol Vis Sci. 2024;9(2):23-29. doi: 10.11648/j.ijovs.20240902.12

    Copy | Download 

  • @article{10.11648/j.ijovs.20240902.12,
  author = {Deepesh Arora and Anuj Sharma and Devesh Sharma and Dinesh Sharma},
  title = {Multimodal Imaging in Diagnosis of Vogt Koyanagi Harada Disease with Reference to Choroid and Retinal Pigment Epithelium
},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {9},
  number = {2},
  pages = {23-29},
  doi = {10.11648/j.ijovs.20240902.12},
  url = {https://doi.org/10.11648/j.ijovs.20240902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20240902.12},
  abstract = {A 48 year dark skinned North Indian male presented first time to our outpatient with history of bilateral visual decline of 3 weeks duration with associated features of headache, myalgia and rhinitus of 4 weeks duration. A detailed examination confirmed bilateral active anterior granulomatous uveitis with bilateral disc oedema with serous retinal detachment. Multimodal imaging examination was carried out with nideks mirante. Diagnosis in favour of vogt koyanagi harada disease was confirmed. The posterior segment was assessed for various changes in acute and remission phase of vogt koyanagi harada disease with fundus fluorescein angiography, fundus autoflourescence, retroillumination and optical coherence tomography. Thickness and structural change related to central macula thickness, retinal pigment epithelium and choroid were assessed pre and post treatment with additional support of optical coherence tomography and retroillumination. Both these techniques were able to document a greater value change pre and post treatment in these structures. Hence we conclude the need to include these techniques in retinal pigment epithelium and choroidal assessment in vogt koyanagi harada disease.
},
 year = {2024}
}

    Copy | Download 

  • TY  - JOUR
T1  - Multimodal Imaging in Diagnosis of Vogt Koyanagi Harada Disease with Reference to Choroid and Retinal Pigment Epithelium

AU  - Deepesh Arora
AU  - Anuj Sharma
AU  - Devesh Sharma
AU  - Dinesh Sharma
Y1  - 2024/05/30
PY  - 2024
N1  - https://doi.org/10.11648/j.ijovs.20240902.12
DO  - 10.11648/j.ijovs.20240902.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 23
EP  - 29
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20240902.12
AB  - A 48 year dark skinned North Indian male presented first time to our outpatient with history of bilateral visual decline of 3 weeks duration with associated features of headache, myalgia and rhinitus of 4 weeks duration. A detailed examination confirmed bilateral active anterior granulomatous uveitis with bilateral disc oedema with serous retinal detachment. Multimodal imaging examination was carried out with nideks mirante. Diagnosis in favour of vogt koyanagi harada disease was confirmed. The posterior segment was assessed for various changes in acute and remission phase of vogt koyanagi harada disease with fundus fluorescein angiography, fundus autoflourescence, retroillumination and optical coherence tomography. Thickness and structural change related to central macula thickness, retinal pigment epithelium and choroid were assessed pre and post treatment with additional support of optical coherence tomography and retroillumination. Both these techniques were able to document a greater value change pre and post treatment in these structures. Hence we conclude the need to include these techniques in retinal pigment epithelium and choroidal assessment in vogt koyanagi harada disease.

VL  - 9
IS  - 2
ER  -

    Copy | Download

Author Information
Download PDF

About Us

Science Publishing Group (SciencePG) is an Open Access publisher, with more than 300 online, peer-reviewed journals covering a wide range of academic disciplines.

Learn More About SciencePG

Products

Information

Important Link

Copyright © 2012 -- 2024 Science Publishing Group – All rights reserved.