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Effects of Co-ingestion of Amino Acids with Fat on Postchallenge Glycemia and Lipidemia in Healthy Young Women

Received: 9 October 2022     Accepted: 3 November 2022     Published: 11 November 2022
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Abstract

Aim: To investigate the effects of co-ingestion of amino acids with fat on postchallenge glycemia and lipidemia. Methods: Nine healthy young Japanese women were enrolled. At each session, the subjects ingested one of three beverages containing fat cream (OFTT™ cream, 1 g/kg body weight, 0.35 g/kg as fat) and/or amino acid mixture (Amizet B™, 600 mg/kg body weight, 60 mg/kg as amino acids) in a randomized crossover design. The three beverages were as follows: fat cream (F trial), amino acid mixture (A trial), or both (FA trial). Venous blood samples were obtained before (0) and 0.5, 1, 2, and 3 h in the A trial, and at 0, 0.5, 1, 2, 4, and 6 h after ingestion in the F and FA trials. Results: Fat ingestion increased the secretion of incretins (GIP and GLP-1), but only a weak effect on insulin secretion was observed. Amino acids ingestion had only a weak effect on the secretion of incretins, but synergistically stimulated the insulin secretion induced by fat ingestion. Glucagon showed behavior similar to that of insulin. There were no significant effects of the co-ingestion of amino acids on lipid or lipoprotein metabolism compared to the ingestion of fat alone. All of these phenomena were observed without a change in blood glucose levels. Conclusion: Fat ingestion stimulated mainly the secretion of incretins via intestinal cells, whereas the amino acid ingestion stimulated mainly insulin secretion by directly acting on pancreatic β cells. The co-ingestion of amino acids with fat may improve postchallenge glucose metabolism, but it had little effect on postchallenge lipid or lipoprotein metabolism.

Published in International Journal of Nutrition and Food Sciences (Volume 11, Issue 6)
DOI 10.11648/j.ijnfs.20221106.11
Page(s) 177-186
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Amino Acids, Postchallenge Glycemia, Postchallenge Lipidemia, Young Women, GIP, GLP-1, Insulin, Glucagon

References
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  • APA Style

    Natsuko Ichikawa, Yukino Morita, Kayo Ootani, Michitaka Naito. (2022). Effects of Co-ingestion of Amino Acids with Fat on Postchallenge Glycemia and Lipidemia in Healthy Young Women. International Journal of Nutrition and Food Sciences, 11(6), 177-186. https://doi.org/10.11648/j.ijnfs.20221106.11

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    ACS Style

    Natsuko Ichikawa; Yukino Morita; Kayo Ootani; Michitaka Naito. Effects of Co-ingestion of Amino Acids with Fat on Postchallenge Glycemia and Lipidemia in Healthy Young Women. Int. J. Nutr. Food Sci. 2022, 11(6), 177-186. doi: 10.11648/j.ijnfs.20221106.11

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    AMA Style

    Natsuko Ichikawa, Yukino Morita, Kayo Ootani, Michitaka Naito. Effects of Co-ingestion of Amino Acids with Fat on Postchallenge Glycemia and Lipidemia in Healthy Young Women. Int J Nutr Food Sci. 2022;11(6):177-186. doi: 10.11648/j.ijnfs.20221106.11

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  • @article{10.11648/j.ijnfs.20221106.11,
      author = {Natsuko Ichikawa and Yukino Morita and Kayo Ootani and Michitaka Naito},
      title = {Effects of Co-ingestion of Amino Acids with Fat on Postchallenge Glycemia and Lipidemia in Healthy Young Women},
      journal = {International Journal of Nutrition and Food Sciences},
      volume = {11},
      number = {6},
      pages = {177-186},
      doi = {10.11648/j.ijnfs.20221106.11},
      url = {https://doi.org/10.11648/j.ijnfs.20221106.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20221106.11},
      abstract = {Aim: To investigate the effects of co-ingestion of amino acids with fat on postchallenge glycemia and lipidemia. Methods: Nine healthy young Japanese women were enrolled. At each session, the subjects ingested one of three beverages containing fat cream (OFTT™ cream, 1 g/kg body weight, 0.35 g/kg as fat) and/or amino acid mixture (Amizet B™, 600 mg/kg body weight, 60 mg/kg as amino acids) in a randomized crossover design. The three beverages were as follows: fat cream (F trial), amino acid mixture (A trial), or both (FA trial). Venous blood samples were obtained before (0) and 0.5, 1, 2, and 3 h in the A trial, and at 0, 0.5, 1, 2, 4, and 6 h after ingestion in the F and FA trials. Results: Fat ingestion increased the secretion of incretins (GIP and GLP-1), but only a weak effect on insulin secretion was observed. Amino acids ingestion had only a weak effect on the secretion of incretins, but synergistically stimulated the insulin secretion induced by fat ingestion. Glucagon showed behavior similar to that of insulin. There were no significant effects of the co-ingestion of amino acids on lipid or lipoprotein metabolism compared to the ingestion of fat alone. All of these phenomena were observed without a change in blood glucose levels. Conclusion: Fat ingestion stimulated mainly the secretion of incretins via intestinal cells, whereas the amino acid ingestion stimulated mainly insulin secretion by directly acting on pancreatic β cells. The co-ingestion of amino acids with fat may improve postchallenge glucose metabolism, but it had little effect on postchallenge lipid or lipoprotein metabolism.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Effects of Co-ingestion of Amino Acids with Fat on Postchallenge Glycemia and Lipidemia in Healthy Young Women
    AU  - Natsuko Ichikawa
    AU  - Yukino Morita
    AU  - Kayo Ootani
    AU  - Michitaka Naito
    Y1  - 2022/11/11
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ijnfs.20221106.11
    DO  - 10.11648/j.ijnfs.20221106.11
    T2  - International Journal of Nutrition and Food Sciences
    JF  - International Journal of Nutrition and Food Sciences
    JO  - International Journal of Nutrition and Food Sciences
    SP  - 177
    EP  - 186
    PB  - Science Publishing Group
    SN  - 2327-2716
    UR  - https://doi.org/10.11648/j.ijnfs.20221106.11
    AB  - Aim: To investigate the effects of co-ingestion of amino acids with fat on postchallenge glycemia and lipidemia. Methods: Nine healthy young Japanese women were enrolled. At each session, the subjects ingested one of three beverages containing fat cream (OFTT™ cream, 1 g/kg body weight, 0.35 g/kg as fat) and/or amino acid mixture (Amizet B™, 600 mg/kg body weight, 60 mg/kg as amino acids) in a randomized crossover design. The three beverages were as follows: fat cream (F trial), amino acid mixture (A trial), or both (FA trial). Venous blood samples were obtained before (0) and 0.5, 1, 2, and 3 h in the A trial, and at 0, 0.5, 1, 2, 4, and 6 h after ingestion in the F and FA trials. Results: Fat ingestion increased the secretion of incretins (GIP and GLP-1), but only a weak effect on insulin secretion was observed. Amino acids ingestion had only a weak effect on the secretion of incretins, but synergistically stimulated the insulin secretion induced by fat ingestion. Glucagon showed behavior similar to that of insulin. There were no significant effects of the co-ingestion of amino acids on lipid or lipoprotein metabolism compared to the ingestion of fat alone. All of these phenomena were observed without a change in blood glucose levels. Conclusion: Fat ingestion stimulated mainly the secretion of incretins via intestinal cells, whereas the amino acid ingestion stimulated mainly insulin secretion by directly acting on pancreatic β cells. The co-ingestion of amino acids with fat may improve postchallenge glucose metabolism, but it had little effect on postchallenge lipid or lipoprotein metabolism.
    VL  - 11
    IS  - 6
    ER  - 

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Author Information
  • School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

  • School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

  • School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

  • School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

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