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Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet

Received: 11 August 2021     Accepted: 2 September 2021     Published: 12 October 2021
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Abstract

In the recent years, obesity has become more prevalent owing to increase habit sedentary. According to many studies, physical activities and nutritherapy could be complementary solutionto this problem. Pawpaw (Carica papaya) is a tropical fruit highly consumed for its flavour and nutritive properties. The present studywas carried out to investigate the effect of some pawpaw’s varieties’ juice on obesity, insulin resistance and atherogenic riskin albino rats under oxidised palm oil and sucrose diet. Healthy males and females Wistar rats received during 13 weeks every day a supplement of oxidised palm oil (25%) sucrose (25%). At the end of this period, animals presenting obesity, insulin resistance and glucose intolerancecharacteristics were randomly separated into 6 groups. Three of these groups (satellite control groups (G III, G IV and G V) returned to standard diet and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), while thethree others groups (OPOS control groups G II, G VI and G VII) continued with oxidised palm oil and sucrose diet (OPOS), and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), respectively during 12 weeks. Oral Glucose Tolerance Test (OGTT) was performed and insulin sensitivity was assessed by performing insulin tolerance test, then determining insulin index (Kitt). Body weight, Lee index, naso-anal length, abdominal fat mass, BMI, faeces relative weight and lipid profilewere measured; Atherogenic risk was calculated. OPOS diet induced overall obesity, abdominal obesity, insulin resistance, dyslipidemia and atherogenic risk, and thenreduced Faeces relative weight in animals (P< 0.001 respectively). Treatment with two varieties of pawpaw fresh juice significantly (P< 0.001) reduced Lee index, naso-anal length, abdominal fat mass andBMI, and increased faeces weight; Glucose tolerance and insulin sensitivity were restored; the lipid profile was improved and the atherogenic risk eliminated both in males and females. These results highlight the obesogenic, hyperglycaemic and dyslipidemic characters of OPOS diet, and show the benefits of pawpaw fresh juice on these metabolic diseases. With complementary studies, we will recommend the consumption of this fruit as complementary solution for theprevention and/or the management of the cardiometabolic risk.

Published in International Journal of Nutrition and Food Sciences (Volume 10, Issue 5)
DOI 10.11648/j.ijnfs.20211005.13
Page(s) 108-116
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Pawpaw (Carica papaya), Oxidised Palm Oil, Sucrose, Obesity, Insulin Resistance

References
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  • APA Style

    Etaga Noel Babayana, Selakong Nzekuie Quelie, Etoundi Omgba Cunegonde Blanche, Mekoulou Ndongo Jerson, Bika Lélé Claude Élisé, et al. (2021). Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet. International Journal of Nutrition and Food Sciences, 10(5), 108-116. https://doi.org/10.11648/j.ijnfs.20211005.13

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    ACS Style

    Etaga Noel Babayana; Selakong Nzekuie Quelie; Etoundi Omgba Cunegonde Blanche; Mekoulou Ndongo Jerson; Bika Lélé Claude Élisé, et al. Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet. Int. J. Nutr. Food Sci. 2021, 10(5), 108-116. doi: 10.11648/j.ijnfs.20211005.13

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    AMA Style

    Etaga Noel Babayana, Selakong Nzekuie Quelie, Etoundi Omgba Cunegonde Blanche, Mekoulou Ndongo Jerson, Bika Lélé Claude Élisé, et al. Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet. Int J Nutr Food Sci. 2021;10(5):108-116. doi: 10.11648/j.ijnfs.20211005.13

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  • @article{10.11648/j.ijnfs.20211005.13,
      author = {Etaga Noel Babayana and Selakong Nzekuie Quelie and Etoundi Omgba Cunegonde Blanche and Mekoulou Ndongo Jerson and Bika Lélé Claude Élisé and Aicha De Nkainsa and Ngaha Marie Ide and Bilog Nadine Carole and Bogning Zangueu Calvin and Mbock Armel Junior and Endougou Effa Anne Marie and Dongmo Alain Bernard and Bongue Bienvenu and Mandengue Samuel Honoré and Ayina Ayina Clarisse Noel},
      title = {Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet},
      journal = {International Journal of Nutrition and Food Sciences},
      volume = {10},
      number = {5},
      pages = {108-116},
      doi = {10.11648/j.ijnfs.20211005.13},
      url = {https://doi.org/10.11648/j.ijnfs.20211005.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20211005.13},
      abstract = {In the recent years, obesity has become more prevalent owing to increase habit sedentary. According to many studies, physical activities and nutritherapy could be complementary solutionto this problem. Pawpaw (Carica papaya) is a tropical fruit highly consumed for its flavour and nutritive properties. The present studywas carried out to investigate the effect of some pawpaw’s varieties’ juice on obesity, insulin resistance and atherogenic riskin albino rats under oxidised palm oil and sucrose diet. Healthy males and females Wistar rats received during 13 weeks every day a supplement of oxidised palm oil (25%) sucrose (25%). At the end of this period, animals presenting obesity, insulin resistance and glucose intolerancecharacteristics were randomly separated into 6 groups. Three of these groups (satellite control groups (G III, G IV and G V) returned to standard diet and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), while thethree others groups (OPOS control groups G II, G VI and G VII) continued with oxidised palm oil and sucrose diet (OPOS), and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), respectively during 12 weeks. Oral Glucose Tolerance Test (OGTT) was performed and insulin sensitivity was assessed by performing insulin tolerance test, then determining insulin index (Kitt). Body weight, Lee index, naso-anal length, abdominal fat mass, BMI, faeces relative weight and lipid profilewere measured; Atherogenic risk was calculated. OPOS diet induced overall obesity, abdominal obesity, insulin resistance, dyslipidemia and atherogenic risk, and thenreduced Faeces relative weight in animals (P< 0.001 respectively). Treatment with two varieties of pawpaw fresh juice significantly (P< 0.001) reduced Lee index, naso-anal length, abdominal fat mass andBMI, and increased faeces weight; Glucose tolerance and insulin sensitivity were restored; the lipid profile was improved and the atherogenic risk eliminated both in males and females. These results highlight the obesogenic, hyperglycaemic and dyslipidemic characters of OPOS diet, and show the benefits of pawpaw fresh juice on these metabolic diseases. With complementary studies, we will recommend the consumption of this fruit as complementary solution for theprevention and/or the management of the cardiometabolic risk.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Carica papaya’s Varieties Improved Obesity, Insulin Resistance and Atherogenic Risk in Rats Fed with Oxidised Palm Oil and Sucrose Diet
    AU  - Etaga Noel Babayana
    AU  - Selakong Nzekuie Quelie
    AU  - Etoundi Omgba Cunegonde Blanche
    AU  - Mekoulou Ndongo Jerson
    AU  - Bika Lélé Claude Élisé
    AU  - Aicha De Nkainsa
    AU  - Ngaha Marie Ide
    AU  - Bilog Nadine Carole
    AU  - Bogning Zangueu Calvin
    AU  - Mbock Armel Junior
    AU  - Endougou Effa Anne Marie
    AU  - Dongmo Alain Bernard
    AU  - Bongue Bienvenu
    AU  - Mandengue Samuel Honoré
    AU  - Ayina Ayina Clarisse Noel
    Y1  - 2021/10/12
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijnfs.20211005.13
    DO  - 10.11648/j.ijnfs.20211005.13
    T2  - International Journal of Nutrition and Food Sciences
    JF  - International Journal of Nutrition and Food Sciences
    JO  - International Journal of Nutrition and Food Sciences
    SP  - 108
    EP  - 116
    PB  - Science Publishing Group
    SN  - 2327-2716
    UR  - https://doi.org/10.11648/j.ijnfs.20211005.13
    AB  - In the recent years, obesity has become more prevalent owing to increase habit sedentary. According to many studies, physical activities and nutritherapy could be complementary solutionto this problem. Pawpaw (Carica papaya) is a tropical fruit highly consumed for its flavour and nutritive properties. The present studywas carried out to investigate the effect of some pawpaw’s varieties’ juice on obesity, insulin resistance and atherogenic riskin albino rats under oxidised palm oil and sucrose diet. Healthy males and females Wistar rats received during 13 weeks every day a supplement of oxidised palm oil (25%) sucrose (25%). At the end of this period, animals presenting obesity, insulin resistance and glucose intolerancecharacteristics were randomly separated into 6 groups. Three of these groups (satellite control groups (G III, G IV and G V) returned to standard diet and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), while thethree others groups (OPOS control groups G II, G VI and G VII) continued with oxidised palm oil and sucrose diet (OPOS), and received a supplement of smooth cayenne and spanich variety of pawpaw (1 ml/100g), respectively during 12 weeks. Oral Glucose Tolerance Test (OGTT) was performed and insulin sensitivity was assessed by performing insulin tolerance test, then determining insulin index (Kitt). Body weight, Lee index, naso-anal length, abdominal fat mass, BMI, faeces relative weight and lipid profilewere measured; Atherogenic risk was calculated. OPOS diet induced overall obesity, abdominal obesity, insulin resistance, dyslipidemia and atherogenic risk, and thenreduced Faeces relative weight in animals (P< 0.001 respectively). Treatment with two varieties of pawpaw fresh juice significantly (P< 0.001) reduced Lee index, naso-anal length, abdominal fat mass andBMI, and increased faeces weight; Glucose tolerance and insulin sensitivity were restored; the lipid profile was improved and the atherogenic risk eliminated both in males and females. These results highlight the obesogenic, hyperglycaemic and dyslipidemic characters of OPOS diet, and show the benefits of pawpaw fresh juice on these metabolic diseases. With complementary studies, we will recommend the consumption of this fruit as complementary solution for theprevention and/or the management of the cardiometabolic risk.
    VL  - 10
    IS  - 5
    ER  - 

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Author Information
  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Department of Biochemistry, University of Douala, Douala, Cameroun

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Laboratoire SAINBIOSE INSERM U1059, Université Jean Monnet, Saint Etienne, France

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

  • Department of Animal and Biology, University of Douala, Douala, Cameroun

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