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Fatty Acids Effect on T Helper Differentiation in Vitro

Received: 16 September 2016     Accepted: 26 September 2016     Published: 17 October 2016
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Abstract

Autoimmunity shows a concerning growth recently. It seems that role of diet is important for development of autoimmunity. Nutritional elements can affect immune system functions. Oversupply or deficiency of specific metabolites may change performance of immune cells, especially that of T helper lymphocytes. For example, glucose, omega 3 and poly unsaturated fatty acids can induce specific Th subsets which play a critical role in autoimmune diseases. T lymphocytes, mostly T CD4+ (Th cells) not only play a critical role in orchestrating immune responses, but also they have major role in pathogenesis of some autoimmune disease. Hence, we designed a research to find out effects of oleic and palmitic acids on differentiation of Th cells. We added oleic acid, palmitic acids and combination of them on peripheral blood mononuclear cells (PBMC) culture and cells were harvested for RT-PCR and flow cytometry analysis after seven days. Our results showed that palmitic and oleic acids induce Th1 and Th17 subsets (p-valu <0.05).

Published in International Journal of Nutrition and Food Sciences (Volume 5, Issue 6)
DOI 10.11648/j.ijnfs.20160506.11
Page(s) 372-377
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

T Helper Cells, Differentiation, Metabolism, Fatty Acids, Mtor

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Cite This Article
  • APA Style

    Aissouda Hossein zade, Maryam Moogooei, Shayan Mostafaei, Hossein Rahavi, Reza Mansouri, et al. (2016). Fatty Acids Effect on T Helper Differentiation in Vitro. International Journal of Nutrition and Food Sciences, 5(6), 372-377. https://doi.org/10.11648/j.ijnfs.20160506.11

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    ACS Style

    Aissouda Hossein zade; Maryam Moogooei; Shayan Mostafaei; Hossein Rahavi; Reza Mansouri, et al. Fatty Acids Effect on T Helper Differentiation in Vitro. Int. J. Nutr. Food Sci. 2016, 5(6), 372-377. doi: 10.11648/j.ijnfs.20160506.11

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    AMA Style

    Aissouda Hossein zade, Maryam Moogooei, Shayan Mostafaei, Hossein Rahavi, Reza Mansouri, et al. Fatty Acids Effect on T Helper Differentiation in Vitro. Int J Nutr Food Sci. 2016;5(6):372-377. doi: 10.11648/j.ijnfs.20160506.11

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  • @article{10.11648/j.ijnfs.20160506.11,
      author = {Aissouda Hossein zade and Maryam Moogooei and Shayan Mostafaei and Hossein Rahavi and Reza Mansouri and Sepideh Soukhtezari and Mojgan Ghaedi},
      title = {Fatty Acids Effect on T Helper Differentiation in Vitro},
      journal = {International Journal of Nutrition and Food Sciences},
      volume = {5},
      number = {6},
      pages = {372-377},
      doi = {10.11648/j.ijnfs.20160506.11},
      url = {https://doi.org/10.11648/j.ijnfs.20160506.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20160506.11},
      abstract = {Autoimmunity shows a concerning growth recently. It seems that role of diet is important for development of autoimmunity. Nutritional elements can affect immune system functions. Oversupply or deficiency of specific metabolites may change performance of immune cells, especially that of T helper lymphocytes. For example, glucose, omega 3 and poly unsaturated fatty acids can induce specific Th subsets which play a critical role in autoimmune diseases. T lymphocytes, mostly T CD4+ (Th cells) not only play a critical role in orchestrating immune responses, but also they have major role in pathogenesis of some autoimmune disease. Hence, we designed a research to find out effects of oleic and palmitic acids on differentiation of Th cells. We added oleic acid, palmitic acids and combination of them on peripheral blood mononuclear cells (PBMC) culture and cells were harvested for RT-PCR and flow cytometry analysis after seven days. Our results showed that palmitic and oleic acids induce Th1 and Th17 subsets (p-valu <0.05).},
     year = {2016}
    }
    

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    T1  - Fatty Acids Effect on T Helper Differentiation in Vitro
    AU  - Aissouda Hossein zade
    AU  - Maryam Moogooei
    AU  - Shayan Mostafaei
    AU  - Hossein Rahavi
    AU  - Reza Mansouri
    AU  - Sepideh Soukhtezari
    AU  - Mojgan Ghaedi
    Y1  - 2016/10/17
    PY  - 2016
    N1  - https://doi.org/10.11648/j.ijnfs.20160506.11
    DO  - 10.11648/j.ijnfs.20160506.11
    T2  - International Journal of Nutrition and Food Sciences
    JF  - International Journal of Nutrition and Food Sciences
    JO  - International Journal of Nutrition and Food Sciences
    SP  - 372
    EP  - 377
    PB  - Science Publishing Group
    SN  - 2327-2716
    UR  - https://doi.org/10.11648/j.ijnfs.20160506.11
    AB  - Autoimmunity shows a concerning growth recently. It seems that role of diet is important for development of autoimmunity. Nutritional elements can affect immune system functions. Oversupply or deficiency of specific metabolites may change performance of immune cells, especially that of T helper lymphocytes. For example, glucose, omega 3 and poly unsaturated fatty acids can induce specific Th subsets which play a critical role in autoimmune diseases. T lymphocytes, mostly T CD4+ (Th cells) not only play a critical role in orchestrating immune responses, but also they have major role in pathogenesis of some autoimmune disease. Hence, we designed a research to find out effects of oleic and palmitic acids on differentiation of Th cells. We added oleic acid, palmitic acids and combination of them on peripheral blood mononuclear cells (PBMC) culture and cells were harvested for RT-PCR and flow cytometry analysis after seven days. Our results showed that palmitic and oleic acids induce Th1 and Th17 subsets (p-valu <0.05).
    VL  - 5
    IS  - 6
    ER  - 

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Author Information
  • Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

  • Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

  • Department of Biostatistics, Tarbiat Modares University, Tehran, Iran

  • Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

  • Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

  • Department of Medical Biotechnology, Tarbiat Modares Univesity, Tehran, Iran

  • Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran

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