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Clinical Course and Outcome of 395 Covid 19 Patients Admitted to One Hospital in Jeddah- Saudi Arabia

Received: 17 September 2020     Accepted: 9 October 2020     Published: 17 October 2020
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Abstract

Background: Since the first case of SARS-CoV 2 has been reported from Wuhan China back in December 2019, the virus has spread all over the world and has so far infected more than 35 million humans and led to more than one million deaths woldwide. We describe in this paper the clinical characteristics and outcome of PCR confirmed Covid 19 patients that were admitted to a tertiary care hospital in Saudi Arabia. Methods: Retrospective review of patients that had positive PCR on nasopharyngeal swab for SARS Cov2 and that were admitted and discharged from a tertiary care hospital in the city of Jeddah, Saudi Arabia between March and July 2020. Epidemiological, demographic, and clinical data were collected. The clinical course of patients was reviewed. Risk factors for involvement of lower respiratory tract (Pneumonia), for need for ICU and for death were analyzed. Results: The records of total of 395 patients were reviewed. 15% of Covid 19 patients in our population were completely asymptomatic, one quarter of which had abnormalities on chest imaging. Among the patients with one or more Covid 19 symptoms, 75% had lower respiratory tract involvement and one quarter had normal chest imaging. One third of all patients developed leukopenia and around 2 thirds had lymphocytopenia. Thrombocytopenia was not common (occurred in 15%), 29% of our patients had CRP>10 and 25.1% had elevated ALT (not exceeding 5 times upper normal). Nine percent of our patients needed ICU admission, 3.8% needed mechanical ventilation. 9 patients (2.3%) in our population died. Advancing age, increasing BMI, and smoking history were significantly associated with increased mortality. Developing abnormalities on chest imaging (Pneumonia) was significantly associated with increasing BMI, advancing age, not receiving BCG vaccination at birth, history of smoking and presence of co-morbidities (p value less 0.05 with all these variables). Blood group and presence of co-morbidities was significantly associated with need for ICU care but not with mortality. In our population neither ethnicity, nor gender, had significant association with hospital course or outcome, and no one younger than 45 years and no one with BMI less than 24 died. Conclusion: Advancing age, increasing BMI and history of smoking were found to be significant risk factors for mortality in our population. History of Bacille calmette Guerin (BCG) vaccination was significantly associated with less involvement of lower respiratory tract but had no significant association with final outcome. Asymptomatic Covid 19 is more of a silent active infection rather than a silent inactive carrier state.

Published in International Journal of Infectious Diseases and Therapy (Volume 5, Issue 4)
DOI 10.11648/j.ijidt.20200504.13
Page(s) 118-126
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Covid 19, Saudi Arabia, BCG Vaccine

References
[1] World Health Organization. https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19—11-march-2020, 2020. March [Accessed 4 April 2020].
[2] MOH News. https://www.moh.gov.sa/en/Ministry/MediaCenter/News/Pages/News-2020-03-02-002.aspx, 2020. March [Accessed 5 April 2020].
[3] Mizumoto K, Kagaya K, Zarebski A, Chowell G. Estimating the asymp-tomatic proportion of coronavirus disease 2019 (COVID-19) cases on boardthe Diamond Princess cruise ship, Yokohama, Japan, 2020. Eurosurveillance 2020; 25 (10), http://dx.doi.org/10.2807/1560-7917.ES.2020.25.10.2000180.
[4] Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of Corona-virus Disease 2019 in China. New Engl J Med 2020, http://dx.doi.org/10.1056/NEJMoa2002032.
[5] Jiang F, Deng L, Zhang L, Cai Y, Cheung C, Xia Z. Review of the clinical character-istics of Coronavirus Disease 2019 (COVID-19). J Gen Intern Med 2020, http://dx.doi.org/10.1007/s11606-020-05762-w.
[6] Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China. Am J Gastroen-terol 2020: 1, http://dx.doi.org/10.14309/ajg.0000000000000620.
[7] Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395 (10223): 497-506.
[8] Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of138 hospitalized patients with 2019 Novel Coronavirus–Infected Pneumoniain Wuhan, China. J Am Med Assoc2020; 323 (11): 1061, http://dx.doi.org/10.1001/jama.2020.1585.
[9] Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, et al. Radiological findingsfrom 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptivestudy. Lancet Infect Dis 2020; 20 (4): 425–34, http://dx.doi.org/10.1016/S1473-3099(20)30086-4.
[10] Alsofyan Y, Althunayyan S, Khan A, Hakawi A, Assiri A (2020) Clinical characteristics of Covid-19 in Saudi Arabia: a national retrospective study. J Infect and public health. https://doi.org/10.1016/j.jiph.2020.05.026.
[11] Liu KC, Xu P, Lv WF, Qiu XH, Yao JL, Gu JF, et al. CT manifestations of coronavirus disease-2019: a retrospective analysis of 73 cases by disease severity. Eur J Radiol. 2020 May; 126: 108941. doi: 10.1016/j.ejrad.2020.108941.
[12] Linton NM, Kobayashi T, Yang Y, Hayashi K, Akhmetzhanov AR, Jung SM, et al. Incubation period and other epidemiological characteristics of 2019 novel coronavirus infections with right truncation: a statistical analysis of publicly available case data. J Clin Med. 2020; 9 (2): 538. doi: 10.3390/jcm9020538.
[13] Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L, et al. Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020; e201291. doi: 10.1001/jamaophthalmol.2020.1291.
[14] Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395: 507-13. doi: 10.1016/S0140-6736(20)30211-7.
[15] Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020. doi: 10.1001/jama.2020.1585.
[16] Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, et al (2020). Genomewide Association Study of Severe Covid-19 with Respiratory Failure, NEJM 2020; DOI: 10.1056/NEJMoa2020283.
[17] Yu C, Zhou M, Liu Y, Guo T, Ou C, et al (2020). Characteristis of asymptomatic Covid 19 infection and progression: A multicenter, retrospective study. Virulence 2020; 11, issue 1.
[18] Long Q, Tang X, Shi Q, Li Q, Deng H, et al (2020). Clinical and immunological asessment of asymotomatic SARS-Cov-2 infections. Nature Medicine 2020; 26: 1200-1204.
[19] Baud D, Qi X, Nielsen-Saines K, Musso D, Pomar L, Favre G. Real estimates of mortality following COVID-19 infection. Lancet Infect Dis. 2020 Mar 12;. doi: 10.1016/S1473-3099(20)30195-X.
[20] Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395 (10229): 1054-62.
[21] Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. March 2020. JAMA Intern Med. 2020 Mar 13; e200994. doi: 10.1001/jamainternmed.2020.0994.
[22] Wang D, Yin Y, Hu C, Liu X, Zhang X, et al. Clinical course and outcome of 107 patients infected with Novel coronavirus, SARS Co-v- 2, discharge dfrom 2 hopsitals in Wuhan. Critical care 2020; 24: 188.
[23] Miller A, Reandelar MJ, Fasciglione K, Roumenova V, Li Yan, Otazu GH. Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID- 19: an epidemiological study. 2020 medRxiv doi: 10.1101/2020.03.24.20042937.
[24] Hegarty PK, Kamat AM, Zafirakis H, Dinardo A. BCG vaccination may be protective against Covid-19. 2020. doi: 10.13140/RG.2.2.35948.10880.
[25] Dayal D, Gupta S (2020). Connecting BCG vaccination and Covid 19: additional data. medRxiv preprint doi: https://doi.org/10.1101/2020.04.07.20053272.
[26] Bai Y, Yao L, Wei T, Jin D, et al (2020). Presumed asymptomatic carrier transmission of Covid 19 JAMA. 2020 Apr 14; 323 (14): 1406–1407.
[27] Arnos MM, Hatfield KM, Reddy SC, Kimball A, James A, et al (2020). Presymptomatic SARS-Cov-2 infections and transmission in a skilled nursing facility. N Engl J Med 2020; 382: 2081-2090.
Cite This Article
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    Samar Assem Badreddine, Mohammed Zammo, Abdullah Abdelfattah Elhosiny, Mohanna Walid Alhomsy, Yasser Aldabbagh, et al. (2020). Clinical Course and Outcome of 395 Covid 19 Patients Admitted to One Hospital in Jeddah- Saudi Arabia. International Journal of Infectious Diseases and Therapy, 5(4), 118-126. https://doi.org/10.11648/j.ijidt.20200504.13

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    ACS Style

    Samar Assem Badreddine; Mohammed Zammo; Abdullah Abdelfattah Elhosiny; Mohanna Walid Alhomsy; Yasser Aldabbagh, et al. Clinical Course and Outcome of 395 Covid 19 Patients Admitted to One Hospital in Jeddah- Saudi Arabia. Int. J. Infect. Dis. Ther. 2020, 5(4), 118-126. doi: 10.11648/j.ijidt.20200504.13

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    AMA Style

    Samar Assem Badreddine, Mohammed Zammo, Abdullah Abdelfattah Elhosiny, Mohanna Walid Alhomsy, Yasser Aldabbagh, et al. Clinical Course and Outcome of 395 Covid 19 Patients Admitted to One Hospital in Jeddah- Saudi Arabia. Int J Infect Dis Ther. 2020;5(4):118-126. doi: 10.11648/j.ijidt.20200504.13

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  • @article{10.11648/j.ijidt.20200504.13,
      author = {Samar Assem Badreddine and Mohammed Zammo and Abdullah Abdelfattah Elhosiny and Mohanna Walid Alhomsy and Yasser Aldabbagh and Abdullah Sameer Mansouri and Sara Hesham Taha and Reem Yahya ALQuraa and Abdulaziz Abdullah Al Nahdi and Ayman Eissa and Hanan Mohammed Faruqui and Nehal Ahmed and Ahmad Alzahrani and Nezar Bahabri},
      title = {Clinical Course and Outcome of 395 Covid 19 Patients Admitted to One Hospital in Jeddah- Saudi Arabia},
      journal = {International Journal of Infectious Diseases and Therapy},
      volume = {5},
      number = {4},
      pages = {118-126},
      doi = {10.11648/j.ijidt.20200504.13},
      url = {https://doi.org/10.11648/j.ijidt.20200504.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20200504.13},
      abstract = {Background: Since the first case of SARS-CoV 2 has been reported from Wuhan China back in December 2019, the virus has spread all over the world and has so far infected more than 35 million humans and led to more than one million deaths woldwide. We describe in this paper the clinical characteristics and outcome of PCR confirmed Covid 19 patients that were admitted to a tertiary care hospital in Saudi Arabia. Methods: Retrospective review of patients that had positive PCR on nasopharyngeal swab for SARS Cov2 and that were admitted and discharged from a tertiary care hospital in the city of Jeddah, Saudi Arabia between March and July 2020. Epidemiological, demographic, and clinical data were collected. The clinical course of patients was reviewed. Risk factors for involvement of lower respiratory tract (Pneumonia), for need for ICU and for death were analyzed. Results: The records of total of 395 patients were reviewed. 15% of Covid 19 patients in our population were completely asymptomatic, one quarter of which had abnormalities on chest imaging. Among the patients with one or more Covid 19 symptoms, 75% had lower respiratory tract involvement and one quarter had normal chest imaging. One third of all patients developed leukopenia and around 2 thirds had lymphocytopenia. Thrombocytopenia was not common (occurred in 15%), 29% of our patients had CRP>10 and 25.1% had elevated ALT (not exceeding 5 times upper normal). Nine percent of our patients needed ICU admission, 3.8% needed mechanical ventilation. 9 patients (2.3%) in our population died. Advancing age, increasing BMI, and smoking history were significantly associated with increased mortality. Developing abnormalities on chest imaging (Pneumonia) was significantly associated with increasing BMI, advancing age, not receiving BCG vaccination at birth, history of smoking and presence of co-morbidities (p value less 0.05 with all these variables). Blood group and presence of co-morbidities was significantly associated with need for ICU care but not with mortality. In our population neither ethnicity, nor gender, had significant association with hospital course or outcome, and no one younger than 45 years and no one with BMI less than 24 died. Conclusion: Advancing age, increasing BMI and history of smoking were found to be significant risk factors for mortality in our population. History of Bacille calmette Guerin (BCG) vaccination was significantly associated with less involvement of lower respiratory tract but had no significant association with final outcome. Asymptomatic Covid 19 is more of a silent active infection rather than a silent inactive carrier state.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Clinical Course and Outcome of 395 Covid 19 Patients Admitted to One Hospital in Jeddah- Saudi Arabia
    AU  - Samar Assem Badreddine
    AU  - Mohammed Zammo
    AU  - Abdullah Abdelfattah Elhosiny
    AU  - Mohanna Walid Alhomsy
    AU  - Yasser Aldabbagh
    AU  - Abdullah Sameer Mansouri
    AU  - Sara Hesham Taha
    AU  - Reem Yahya ALQuraa
    AU  - Abdulaziz Abdullah Al Nahdi
    AU  - Ayman Eissa
    AU  - Hanan Mohammed Faruqui
    AU  - Nehal Ahmed
    AU  - Ahmad Alzahrani
    AU  - Nezar Bahabri
    Y1  - 2020/10/17
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ijidt.20200504.13
    DO  - 10.11648/j.ijidt.20200504.13
    T2  - International Journal of Infectious Diseases and Therapy
    JF  - International Journal of Infectious Diseases and Therapy
    JO  - International Journal of Infectious Diseases and Therapy
    SP  - 118
    EP  - 126
    PB  - Science Publishing Group
    SN  - 2578-966X
    UR  - https://doi.org/10.11648/j.ijidt.20200504.13
    AB  - Background: Since the first case of SARS-CoV 2 has been reported from Wuhan China back in December 2019, the virus has spread all over the world and has so far infected more than 35 million humans and led to more than one million deaths woldwide. We describe in this paper the clinical characteristics and outcome of PCR confirmed Covid 19 patients that were admitted to a tertiary care hospital in Saudi Arabia. Methods: Retrospective review of patients that had positive PCR on nasopharyngeal swab for SARS Cov2 and that were admitted and discharged from a tertiary care hospital in the city of Jeddah, Saudi Arabia between March and July 2020. Epidemiological, demographic, and clinical data were collected. The clinical course of patients was reviewed. Risk factors for involvement of lower respiratory tract (Pneumonia), for need for ICU and for death were analyzed. Results: The records of total of 395 patients were reviewed. 15% of Covid 19 patients in our population were completely asymptomatic, one quarter of which had abnormalities on chest imaging. Among the patients with one or more Covid 19 symptoms, 75% had lower respiratory tract involvement and one quarter had normal chest imaging. One third of all patients developed leukopenia and around 2 thirds had lymphocytopenia. Thrombocytopenia was not common (occurred in 15%), 29% of our patients had CRP>10 and 25.1% had elevated ALT (not exceeding 5 times upper normal). Nine percent of our patients needed ICU admission, 3.8% needed mechanical ventilation. 9 patients (2.3%) in our population died. Advancing age, increasing BMI, and smoking history were significantly associated with increased mortality. Developing abnormalities on chest imaging (Pneumonia) was significantly associated with increasing BMI, advancing age, not receiving BCG vaccination at birth, history of smoking and presence of co-morbidities (p value less 0.05 with all these variables). Blood group and presence of co-morbidities was significantly associated with need for ICU care but not with mortality. In our population neither ethnicity, nor gender, had significant association with hospital course or outcome, and no one younger than 45 years and no one with BMI less than 24 died. Conclusion: Advancing age, increasing BMI and history of smoking were found to be significant risk factors for mortality in our population. History of Bacille calmette Guerin (BCG) vaccination was significantly associated with less involvement of lower respiratory tract but had no significant association with final outcome. Asymptomatic Covid 19 is more of a silent active infection rather than a silent inactive carrier state.
    VL  - 5
    IS  - 4
    ER  - 

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Author Information
  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Infection Control, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Laboratory Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

  • Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia

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