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Correlation Between Current Histopathological Grading and Clinical Features of Mucoepidermoid Carcinoma of the Salivary Glands

Received: 11 August 2022     Accepted: 27 September 2022     Published: 30 November 2022
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Abstract

Mucoepidermoid carcinoma (MEC) is a salivary malignancy with a widely diverse biologic behavior. Mucoepidermoid tumors are the one malignancy in which histologic grading and clinical behavior characteristics correlate. It is the most common among the different types of salivary gland cancer. Usually, these cancers are low-grade in nature but can realize into intermediate or high grade. The biological outcome of such cancer cases can be predicted using clinical and histological grading. The aim of the present study was to observe and evaluate the correlation between histopathological grading and clinical features of mucoepidermoid carcinoma of salivary glands, to determine whether an accurate diagnosis can be made based primarily on clinical findings. This observational descriptive cross-sectional multi-center study was conducted at the Department of Oral and Maxillofacial Surgery, Dhaka Dental College Hospital, Dhaka, Department of Otolaryngology &Head Neck Surgery, Dhaka Medical College Hospital, Dhaka, and Department of Otolaryngology-Head Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study duration was 1.5 years, from July 2011 to December 2012. A total of 20 patients attending the study centers with diagnosed case of mucoepidermoid carcinoma of salivary glands was selected for the study following inclusion and exclusion criteria. 40% of the participants were from the age group of 31-40 years, while another 30% were under the age of 21 years. 70% of the participants were female. Histological grading of the participants revealed 8 low-grade, 8 intermediate grade, and 4 high-grade MEC tumor cases. High-grade tumor MEC had an association with increasing age and male gender. The swelling was a common clinical feature among all the participants, whereas ulceration was observed in 75% of high-grade tumor patients. In mucoepidermoid carcinoma (MEC) of the salivary glands, it was suggested that the histopathological grade of MEC evaluated by Brandwein point-based histological grading schema significantly correlated with age, gender, and clinical features. These results suggest and emphasize that histological grading of MEC, as well as clinical features, should be considered when planning surgery for the MEC and the necessity of treatment outcome.

Published in International Journal of Dental Medicine (Volume 8, Issue 2)
DOI 10.11648/j.ijdm.20220802.11
Page(s) 45-49
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Histological, Tumor, Carcinoma, MEC, Mucoepidermoid

References
[1] Brandwein, M. S., Ivanov, K., Wallace, D. I., Hille, J. J., Wang, B., Fahmy, A., et al. 2001. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol, 25, 835–845.
[2] Regezi, J. A., Scuibba, J. J., Jordan, RCK., 2008. ORAL PATHOLOGY: CLINICAL PATHOLOGIC CORRELATIONS. 5th ed. Philadelphia: W. B Saunders Elsevier Health Sciences, 203.
[3] Seethala RR. An update on grading of salivary gland carcinomas. Head and neck pathology. 2009 Mar; 3 (1): 69-77.
[4] Brandwein, M. S., Ferlito, A., Bradley, P. J., et al. 2002. Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes. Acta Otolaryngol, 122 (7), 758–64.
[5] Ellis, G., Auclair, P., editors, 1996. Tumors of the salivary glands. Atlas of tumor pathology. No. 17, 3rd Series ed, Washington DC: Armed Forces Institute of Pathology.
[6] Auclair, P. L., Goode, R. K., Ellis, G. L., 1992. Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases. Cancer, 69, 2021–2030.
[7] Liu S, Ow A, Ruan M, Yang W, Zhang C, Wang L. Prognostic factors in primary salivary gland mucoepidermoid carcinoma: an analysis of 376 cases in an Eastern Chinese population. International journal of oral and maxillofacial surgery. 2014 Jun 1; 43 (6): 667-73.
[8] Ito FA, Ito K, Vargas PA, De Almeida OP, Lopes MA. Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. International journal of oral and maxillofacial surgery. 2005 Jul 1; 34 (5): 533-6.
[9] Chen MM, Roman SA, Sosa JA, Judson BL. Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients. Head & neck. 2014 Feb; 36 (2): 158-63.
[10] Nance, M. A., Seethala, R. R., Wang, Y., Chiosea, S. I., Myers, E. N., Johnson, J. T., et al. 2008. Treatment and Survival Outcomes Based on Histologic Grading in Patients with Head and Neck Mucoepidermoid Carcinoma. Cancer, 113, 2082-9.
[11] Malinchoc, S., 2017. Evaluating histologic grading systems and the expression of human cytomegalovirus in salivary gland mucoepidermoid carcinoma.
[12] Forghani, R., Savadjiev, P., Chatterjee, A., Muthukrishnan, N., Reinhold, C. and Forghani, B., 2019. Radiomics and artificial intelligence for biomarker and prediction model development in oncology. Computational and structural biotechnology journal, 17, p. 995.
[13] Hughes, J. H., Volk, E. E., Wilbur, D. C., 2005. Pitfalls in salivary gland fine-needle aspiration cytology: lessons from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Archives of Pathology and Laboratory Medicine, vol. 129, no. 1, 26–31.
[14] Gupta, C. and Yadav, K., 2016. Diagnostic Problems in Cytological Diagnosis of Mucoepidermoid Carcinoma: Report of 6 Cases with Histopathological Correlation. Education (ASME), 3 (1), p. 76.
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    Shaheen Ahamed, Mohammad Morshed Alam, Sumanta Kumar Gain, Niaz Ahmed, Mausumi Iqbal. (2022). Correlation Between Current Histopathological Grading and Clinical Features of Mucoepidermoid Carcinoma of the Salivary Glands. International Journal of Dental Medicine, 8(2), 45-49. https://doi.org/10.11648/j.ijdm.20220802.11

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    ACS Style

    Shaheen Ahamed; Mohammad Morshed Alam; Sumanta Kumar Gain; Niaz Ahmed; Mausumi Iqbal. Correlation Between Current Histopathological Grading and Clinical Features of Mucoepidermoid Carcinoma of the Salivary Glands. Int. J. Dent. Med. 2022, 8(2), 45-49. doi: 10.11648/j.ijdm.20220802.11

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    AMA Style

    Shaheen Ahamed, Mohammad Morshed Alam, Sumanta Kumar Gain, Niaz Ahmed, Mausumi Iqbal. Correlation Between Current Histopathological Grading and Clinical Features of Mucoepidermoid Carcinoma of the Salivary Glands. Int J Dent Med. 2022;8(2):45-49. doi: 10.11648/j.ijdm.20220802.11

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  • @article{10.11648/j.ijdm.20220802.11,
      author = {Shaheen Ahamed and Mohammad Morshed Alam and Sumanta Kumar Gain and Niaz Ahmed and Mausumi Iqbal},
      title = {Correlation Between Current Histopathological Grading and Clinical Features of Mucoepidermoid Carcinoma of the Salivary Glands},
      journal = {International Journal of Dental Medicine},
      volume = {8},
      number = {2},
      pages = {45-49},
      doi = {10.11648/j.ijdm.20220802.11},
      url = {https://doi.org/10.11648/j.ijdm.20220802.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijdm.20220802.11},
      abstract = {Mucoepidermoid carcinoma (MEC) is a salivary malignancy with a widely diverse biologic behavior. Mucoepidermoid tumors are the one malignancy in which histologic grading and clinical behavior characteristics correlate. It is the most common among the different types of salivary gland cancer. Usually, these cancers are low-grade in nature but can realize into intermediate or high grade. The biological outcome of such cancer cases can be predicted using clinical and histological grading. The aim of the present study was to observe and evaluate the correlation between histopathological grading and clinical features of mucoepidermoid carcinoma of salivary glands, to determine whether an accurate diagnosis can be made based primarily on clinical findings. This observational descriptive cross-sectional multi-center study was conducted at the Department of Oral and Maxillofacial Surgery, Dhaka Dental College Hospital, Dhaka, Department of Otolaryngology &Head Neck Surgery, Dhaka Medical College Hospital, Dhaka, and Department of Otolaryngology-Head Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study duration was 1.5 years, from July 2011 to December 2012. A total of 20 patients attending the study centers with diagnosed case of mucoepidermoid carcinoma of salivary glands was selected for the study following inclusion and exclusion criteria. 40% of the participants were from the age group of 31-40 years, while another 30% were under the age of 21 years. 70% of the participants were female. Histological grading of the participants revealed 8 low-grade, 8 intermediate grade, and 4 high-grade MEC tumor cases. High-grade tumor MEC had an association with increasing age and male gender. The swelling was a common clinical feature among all the participants, whereas ulceration was observed in 75% of high-grade tumor patients. In mucoepidermoid carcinoma (MEC) of the salivary glands, it was suggested that the histopathological grade of MEC evaluated by Brandwein point-based histological grading schema significantly correlated with age, gender, and clinical features. These results suggest and emphasize that histological grading of MEC, as well as clinical features, should be considered when planning surgery for the MEC and the necessity of treatment outcome.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Correlation Between Current Histopathological Grading and Clinical Features of Mucoepidermoid Carcinoma of the Salivary Glands
    AU  - Shaheen Ahamed
    AU  - Mohammad Morshed Alam
    AU  - Sumanta Kumar Gain
    AU  - Niaz Ahmed
    AU  - Mausumi Iqbal
    Y1  - 2022/11/30
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ijdm.20220802.11
    DO  - 10.11648/j.ijdm.20220802.11
    T2  - International Journal of Dental Medicine
    JF  - International Journal of Dental Medicine
    JO  - International Journal of Dental Medicine
    SP  - 45
    EP  - 49
    PB  - Science Publishing Group
    SN  - 2472-1387
    UR  - https://doi.org/10.11648/j.ijdm.20220802.11
    AB  - Mucoepidermoid carcinoma (MEC) is a salivary malignancy with a widely diverse biologic behavior. Mucoepidermoid tumors are the one malignancy in which histologic grading and clinical behavior characteristics correlate. It is the most common among the different types of salivary gland cancer. Usually, these cancers are low-grade in nature but can realize into intermediate or high grade. The biological outcome of such cancer cases can be predicted using clinical and histological grading. The aim of the present study was to observe and evaluate the correlation between histopathological grading and clinical features of mucoepidermoid carcinoma of salivary glands, to determine whether an accurate diagnosis can be made based primarily on clinical findings. This observational descriptive cross-sectional multi-center study was conducted at the Department of Oral and Maxillofacial Surgery, Dhaka Dental College Hospital, Dhaka, Department of Otolaryngology &Head Neck Surgery, Dhaka Medical College Hospital, Dhaka, and Department of Otolaryngology-Head Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study duration was 1.5 years, from July 2011 to December 2012. A total of 20 patients attending the study centers with diagnosed case of mucoepidermoid carcinoma of salivary glands was selected for the study following inclusion and exclusion criteria. 40% of the participants were from the age group of 31-40 years, while another 30% were under the age of 21 years. 70% of the participants were female. Histological grading of the participants revealed 8 low-grade, 8 intermediate grade, and 4 high-grade MEC tumor cases. High-grade tumor MEC had an association with increasing age and male gender. The swelling was a common clinical feature among all the participants, whereas ulceration was observed in 75% of high-grade tumor patients. In mucoepidermoid carcinoma (MEC) of the salivary glands, it was suggested that the histopathological grade of MEC evaluated by Brandwein point-based histological grading schema significantly correlated with age, gender, and clinical features. These results suggest and emphasize that histological grading of MEC, as well as clinical features, should be considered when planning surgery for the MEC and the necessity of treatment outcome.
    VL  - 8
    IS  - 2
    ER  - 

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Author Information
  • Department of Oral and Maxillofacial Surgery, Dental Unit, Rajshahi Medical College, Rajshahi, Bangladesh

  • Department of Oral and Maxillofacial Surgery, Dental Unit Chattogram Medical College, Chattogram, Bangladesh

  • Department of Oral and Maxillofacial Surgery, Dhaka Dental College Hospital, Dhaka, Bangladesh

  • Department of Oral and Maxillofacial Surgery, Dental Unit Chattogram Medical College, Chattogram, Bangladesh

  • Department of Oral and Maxillofacial Surgery, Anwar Khan Modern Medical College Hospital, Dhaka, Bangladesh

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