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Serological Evidence of Hantavirus Infection in Suspected Cases of Viral Haemorrhagic Fever in Conakry, Guinea

Received: 27 November 2023     Accepted: 19 December 2023     Published: 28 December 2023
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Abstract

Background: Hantaviruses are enzootic haemorrhagic fever viruses whose transmission to humans can cause serious illness with mortality rates ranging from 12% to 40%. Objective: This study aimed to estimate the seroprevalence of IgG antibodies against hantaviruses in the Conakry region. Methods: This was a cross-sectional study of suspected haemorrhagic fever cases. Blood samples were analysed at the Guinea Virology Research Center, Conakry, Republic of Guinea. The indirect enzyme-linked immunosorbent assay (Euro-Immun, vector-best, Russia) was used to detect the presence of specific IgG antibodies to hantaviruses according to the manufacturer's instructions. Results: A total of 368 suspected cases of haemorrhagic fever were reported between 2021 and 2022 in public health facilities in Conakry. The seroprevalence of IgG in patients was 8.7% (95% CI: 6.1-12.0). Patients under 30 years of age were the group most affected (14.9%). The seroprevalence of hantaviruses was significantly higher in trades worker (16.0%) than in other socio-professional categories (p<0.001). Patients with fever associated with anorexia and cough had a hantavirus IgG seroprevalence of 45.5% and 28.9% respectively. Conclusion: This study provided serological evidence of hantavirus circulation in the Conakry region. Active surveillance of hantaviruses, including molecular biology and serotyping, would be necessary to improve our understanding of the ecology of circulating hantavirus strains.

Published in Central African Journal of Public Health (Volume 9, Issue 6)
DOI 10.11648/j.cajph.20230906.14
Page(s) 182-186
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Guinea, Hantavirus, Hemorrhagic Fevers, Serological

References
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    Traoré, S., Talassone Bangoura, S., Camara, A., Youla, Y., Ibrahim, N., et al. (2023). Serological Evidence of Hantavirus Infection in Suspected Cases of Viral Haemorrhagic Fever in Conakry, Guinea. Central African Journal of Public Health, 9(6), 182-186. https://doi.org/10.11648/j.cajph.20230906.14

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    ACS Style

    Traoré, S.; Talassone Bangoura, S.; Camara, A.; Youla, Y.; Ibrahim, N., et al. Serological Evidence of Hantavirus Infection in Suspected Cases of Viral Haemorrhagic Fever in Conakry, Guinea. Cent. Afr. J. Public Health 2023, 9(6), 182-186. doi: 10.11648/j.cajph.20230906.14

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    AMA Style

    Traoré S, Talassone Bangoura S, Camara A, Youla Y, Ibrahim N, et al. Serological Evidence of Hantavirus Infection in Suspected Cases of Viral Haemorrhagic Fever in Conakry, Guinea. Cent Afr J Public Health. 2023;9(6):182-186. doi: 10.11648/j.cajph.20230906.14

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  • @article{10.11648/j.cajph.20230906.14,
      author = {Sékou Traoré and Salifou Talassone Bangoura and Alimou Camara and Yamoussa Youla and Nourdine Ibrahim and Maladho Diaby and Kadio Jean-Jacques Olivier Kadio and Saidouba Cherif Camara and Tanou Valdez Bah and Foromo Timothée Beavogui and Sidikiba Sidibé and Abdoulaye Touré and Sanaba Boumbaly},
      title = {Serological Evidence of Hantavirus Infection in Suspected Cases of Viral Haemorrhagic Fever in Conakry, Guinea},
      journal = {Central African Journal of Public Health},
      volume = {9},
      number = {6},
      pages = {182-186},
      doi = {10.11648/j.cajph.20230906.14},
      url = {https://doi.org/10.11648/j.cajph.20230906.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20230906.14},
      abstract = {Background: Hantaviruses are enzootic haemorrhagic fever viruses whose transmission to humans can cause serious illness with mortality rates ranging from 12% to 40%. Objective: This study aimed to estimate the seroprevalence of IgG antibodies against hantaviruses in the Conakry region. Methods: This was a cross-sectional study of suspected haemorrhagic fever cases. Blood samples were analysed at the Guinea Virology Research Center, Conakry, Republic of Guinea. The indirect enzyme-linked immunosorbent assay (Euro-Immun, vector-best, Russia) was used to detect the presence of specific IgG antibodies to hantaviruses according to the manufacturer's instructions. Results: A total of 368 suspected cases of haemorrhagic fever were reported between 2021 and 2022 in public health facilities in Conakry. The seroprevalence of IgG in patients was 8.7% (95% CI: 6.1-12.0). Patients under 30 years of age were the group most affected (14.9%). The seroprevalence of hantaviruses was significantly higher in trades worker (16.0%) than in other socio-professional categories (p<0.001). Patients with fever associated with anorexia and cough had a hantavirus IgG seroprevalence of 45.5% and 28.9% respectively. Conclusion: This study provided serological evidence of hantavirus circulation in the Conakry region. Active surveillance of hantaviruses, including molecular biology and serotyping, would be necessary to improve our understanding of the ecology of circulating hantavirus strains.
    },
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Serological Evidence of Hantavirus Infection in Suspected Cases of Viral Haemorrhagic Fever in Conakry, Guinea
    AU  - Sékou Traoré
    AU  - Salifou Talassone Bangoura
    AU  - Alimou Camara
    AU  - Yamoussa Youla
    AU  - Nourdine Ibrahim
    AU  - Maladho Diaby
    AU  - Kadio Jean-Jacques Olivier Kadio
    AU  - Saidouba Cherif Camara
    AU  - Tanou Valdez Bah
    AU  - Foromo Timothée Beavogui
    AU  - Sidikiba Sidibé
    AU  - Abdoulaye Touré
    AU  - Sanaba Boumbaly
    Y1  - 2023/12/28
    PY  - 2023
    N1  - https://doi.org/10.11648/j.cajph.20230906.14
    DO  - 10.11648/j.cajph.20230906.14
    T2  - Central African Journal of Public Health
    JF  - Central African Journal of Public Health
    JO  - Central African Journal of Public Health
    SP  - 182
    EP  - 186
    PB  - Science Publishing Group
    SN  - 2575-5781
    UR  - https://doi.org/10.11648/j.cajph.20230906.14
    AB  - Background: Hantaviruses are enzootic haemorrhagic fever viruses whose transmission to humans can cause serious illness with mortality rates ranging from 12% to 40%. Objective: This study aimed to estimate the seroprevalence of IgG antibodies against hantaviruses in the Conakry region. Methods: This was a cross-sectional study of suspected haemorrhagic fever cases. Blood samples were analysed at the Guinea Virology Research Center, Conakry, Republic of Guinea. The indirect enzyme-linked immunosorbent assay (Euro-Immun, vector-best, Russia) was used to detect the presence of specific IgG antibodies to hantaviruses according to the manufacturer's instructions. Results: A total of 368 suspected cases of haemorrhagic fever were reported between 2021 and 2022 in public health facilities in Conakry. The seroprevalence of IgG in patients was 8.7% (95% CI: 6.1-12.0). Patients under 30 years of age were the group most affected (14.9%). The seroprevalence of hantaviruses was significantly higher in trades worker (16.0%) than in other socio-professional categories (p<0.001). Patients with fever associated with anorexia and cough had a hantavirus IgG seroprevalence of 45.5% and 28.9% respectively. Conclusion: This study provided serological evidence of hantavirus circulation in the Conakry region. Active surveillance of hantaviruses, including molecular biology and serotyping, would be necessary to improve our understanding of the ecology of circulating hantavirus strains.
    
    VL  - 9
    IS  - 6
    ER  - 

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Author Information
  • Department of Pharmaceutical and Biological Sciences, Gamal Abdel Nasser University, Conakry, Republic of Guinea; Guinea Virology Research Center, Conakry, Republic of Guinea

  • Department of Pharmaceutical and Biological Sciences, Gamal Abdel Nasser University, Conakry, Republic of Guinea; Guinea Center for Research and Training in Infectious Diseases (CERFIG), Gamal Abdel Nasser University, Conakry, Republic of Guinea

  • Department of Pharmaceutical and Biological Sciences, Gamal Abdel Nasser University, Conakry, Republic of Guinea; Guinea Virology Research Center, Conakry, Republic of Guinea

  • Department of Pharmaceutical and Biological Sciences, Gamal Abdel Nasser University, Conakry, Republic of Guinea

  • Guinea Virology Research Center, Conakry, Republic of Guinea

  • Department of Pharmaceutical and Biological Sciences, Gamal Abdel Nasser University, Conakry, Republic of Guinea; Guinea Center for Research and Training in Infectious Diseases (CERFIG), Gamal Abdel Nasser University, Conakry, Republic of Guinea

  • Department of Pharmaceutical and Biological Sciences, Gamal Abdel Nasser University, Conakry, Republic of Guinea; Guinea Center for Research and Training in Infectious Diseases (CERFIG), Gamal Abdel Nasser University, Conakry, Republic of Guinea

  • Guinea Center for Research and Training in Infectious Diseases (CERFIG), Gamal Abdel Nasser University, Conakry, Republic of Guinea

  • Department of Pharmaceutical and Biological Sciences, Gamal Abdel Nasser University, Conakry, Republic of Guinea; Institute for Research and Development of Medicinal and Food Plants of Guinea, Dubreka, Republic of Guinea

  • African Centre of Excellence in the Prevention and Control of Communicable Diseases (CEA-PCMT), Faculty of Sciences and Health Techniques, Gamal Abdel Nasser University, Conakry, Republic of Guinea

  • African Centre of Excellence in the Prevention and Control of Communicable Diseases (CEA-PCMT), Faculty of Sciences and Health Techniques, Gamal Abdel Nasser University, Conakry, Republic of Guinea

  • Department of Pharmaceutical and Biological Sciences, Gamal Abdel Nasser University, Conakry, Republic of Guinea; Guinea Center for Research and Training in Infectious Diseases (CERFIG), Gamal Abdel Nasser University, Conakry, Republic of Guinea

  • Guinea Virology Research Center, Conakry, Republic of Guinea

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