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Maternal-Fetal Prognosis of Pregnancy and Childbirth in Sickle-Cell Patients at the Bernard Kouchner Community Medical Centre of Coronthie in Conakry (Guinea)

Received: 3 October 2023     Accepted: 30 October 2023     Published: 11 December 2023
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Abstract

Introduction: Sickle cell anaemia is an autosomal recessive inherited haemoglobin disorder caused by the presence of high concentrations of abnormal haemoglobin, haemoglobin S, in the red blood cell. Pregnancy is not contraindicated in women with sickle cell disease, but it is a high-risk situation for both mother and foetus. Observed maternal mortality varies from 0.5 to 5%. The aim of this study was to describe the management and maternal-fetal prognosis of sickle cell disease during pregnancy and childbirth. Patients and methods: This was a prospective longitudinal descriptive study conducted over 12 months (1 January to 31 December 2022) in the gynaecology-obstetrics department of the Bernard Kouchner community medical centre in Coronthie, Conakry (Guinea). Pregnant women were included following diagnostic confirmation of sickle cell disease by haemoglobin electrophoresis. Results: During the study period, 43 (8.1%) of the 533 pregnant women attending antenatal clinics met our inclusion criteria. The mean age was 27.83 years, with extremes of 16 and 40 years. Professional women were the most affected (41.8%). Primiparous women and women with no schooling represented 51.2% and 39.5% of our study population respectively. The medical and obstetric history was dominated by vaso-occlusive crises (46.5%), followed by anaemia (23.2%), miscarriage (11.6%), genital infections (6.9%) and foetal death in utero (4.7%). We noted three types of sickle cell phenotype with varying proportions: the AS phenotype (65%), the SC phenotype (23%) and the SS phenotype (12%). Complications were mainly anaemia (27.9%), vaso-occlusive crises (13.9%), retroplacental haematoma (6.9%), premature rupture of membranes (6.9%), urinary tract infection (4, 6%), hypertension (2.3%), acute foetal distress (11.6%), hypotrophy (4.7), intrapartum foetal death (4.7%), in-utero foetal death (2.3%) and intrauterine growth retardation (2.3%). Conclusion: Sickle cell disease in pregnant women is common in our context and often leads to maternal and perinatal complications. The Emmel test should be performed systematically at each first antenatal consultation, along with haemoglobin electrophoresis.

Published in Central African Journal of Public Health (Volume 9, Issue 6)
DOI 10.11648/j.cajph.20230906.12
Page(s) 167-171
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Sickle Cell Disease, Pregnancy, Delivery, Maternal-Fetal Prognosis, Conakry

References
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[2] Lambert M, Raccah-Tebeka B, Plu-Bureau G. Contraception and sickle cell disease, contraception in practice Elsevier Masson SAS 2013; chapitre 43: 194-6.
[3] Houndeffo T, Adisso S, Tshabu-Aguemon C, Rahimy Mc. Houssou FK, De Souza J et al. Pregnancy in sickle cell disease. Journal of the Society of Clinical Biology 2013; 018: 36-42.
[4] Dr Mathieu Schoeffler Anaesthesia and sickle cell disease 15th ICAR Congress, LYON, 2008 https://icarweb.fr/IMG/pdf/15-15.pdf
[5] Serraj K, Houda B, Hamaz S, Alaoui H, Lorenzo Villalba N, Zulfiqar AA, Andrès E. Drépanocytose et grossesse: approche pratique. mt 2019; 25 (6): 408-412. doi: 10.1684/met.2020.0824.
[6] Berzolla C, Seligman NS, Nnoli A, Dysart K, Baxter JK, Ballas SK. Sickle cell disease and pregnancy: does outcome depend on genotype or phenotype? International Journal of Clinical Medicine, 2011; 2 (3), 313-317.
[7] Ohiohin AG, Kalejaiye OO, David AN, Ohihoin EN, Herbertson EC, Gbajabiamila TA et al. Obstetric Challenges of Sickle Cell Disease in Pregnancy. Tropical Journal of Obstetrics & Gynaecology 2020; 37 (2): 2073- 278.
[8] Tchente CN, Brulet C, Njiengwe E, Nana TN, Tsingaing JK, Chantraine F. Antenatal diagnosis of sickle cell disease in Cameroon: the experience of the Douala antenatal diagnosis staff. Journal de la SAGO 2016: 17: 2: 33-7.
[9] Bonkian. C Drépanocytose et grossesse: revue de 13 observations à la Maternité Régionale Universitaire A. PINARD; Université Henri-Poincaré, Nancy 1; 2009: 495208226: 8-19.
[10] Mbodji. A Identification of risk factors for maternal and foetal complications in patients with major sickle cell syndrome: 198 cases. Mémoire du diplôme d'Etat de sage-femme; université Paris Descartes- ESF Baudelocque; 2012: 2012PA05MA24: 2-10;
[11] Ribeil JA French-Brazilian study on pregnancy in sickle cell disease. A study by the international sickle cell disease observatory. Symposia / Clinical and Biological Transfusion 2013; 20: 261-284.
[12] Igala M, Bang Ntamack JA, Ledaga Lentombo LE, Assoumou Obiang P, Ngossanga Bissala PD, Meye JF. Maternal and foetal outcome of pregnancies in women with sickle cell disease in Libreville. Health Sci. Dis: 2022; 23 (5): 6-10.
[13] Zamané H, Kain D, Kiemtoré S, Diallo A, Valéa J, Diallo et al. Preventive exchange blood transfusion in pregnant women with Sickle Cell Disease: Maternal and Perinatal Prognosis in a Country with Limited Resources, Burkina Faso. Open Journal of Obstetrics and Gynecology 2016; 6 (6): 373-378.
[14] Barfield WD, Barradas DT, Manning SE, Kotelchuck M, Shapiro-Mendoza CK. Sickle cell disease and pregnancy outcome: women of African descent. Suis J Préc Med 2010; 38 (4S): S542-9.
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  • APA Style

    Tamba Julien, T., Daniel William Athanase, L., Maimouna, B., Souleymane, T., Moussa, C., et al. (2023). Maternal-Fetal Prognosis of Pregnancy and Childbirth in Sickle-Cell Patients at the Bernard Kouchner Community Medical Centre of Coronthie in Conakry (Guinea). Central African Journal of Public Health, 9(6), 167-171. https://doi.org/10.11648/j.cajph.20230906.12

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    ACS Style

    Tamba Julien, T.; Daniel William Athanase, L.; Maimouna, B.; Souleymane, T.; Moussa, C., et al. Maternal-Fetal Prognosis of Pregnancy and Childbirth in Sickle-Cell Patients at the Bernard Kouchner Community Medical Centre of Coronthie in Conakry (Guinea). Cent. Afr. J. Public Health 2023, 9(6), 167-171. doi: 10.11648/j.cajph.20230906.12

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    AMA Style

    Tamba Julien T, Daniel William Athanase L, Maimouna B, Souleymane T, Moussa C, et al. Maternal-Fetal Prognosis of Pregnancy and Childbirth in Sickle-Cell Patients at the Bernard Kouchner Community Medical Centre of Coronthie in Conakry (Guinea). Cent Afr J Public Health. 2023;9(6):167-171. doi: 10.11648/j.cajph.20230906.12

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  • @article{10.11648/j.cajph.20230906.12,
      author = {Tolno Tamba Julien and Leno Daniel William Athanase and Balde Maimouna and Toure Souleymane and Camara Moussa and Tolno Pascal and Bangoura Salematou and Diallo Abdourahamane and Sy Telly and Hyjazi Yolande and Keita Namory},
      title = {Maternal-Fetal Prognosis of Pregnancy and Childbirth in Sickle-Cell Patients at the Bernard Kouchner Community Medical Centre of Coronthie in Conakry (Guinea)},
      journal = {Central African Journal of Public Health},
      volume = {9},
      number = {6},
      pages = {167-171},
      doi = {10.11648/j.cajph.20230906.12},
      url = {https://doi.org/10.11648/j.cajph.20230906.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20230906.12},
      abstract = {Introduction: Sickle cell anaemia is an autosomal recessive inherited haemoglobin disorder caused by the presence of high concentrations of abnormal haemoglobin, haemoglobin S, in the red blood cell. Pregnancy is not contraindicated in women with sickle cell disease, but it is a high-risk situation for both mother and foetus. Observed maternal mortality varies from 0.5 to 5%. The aim of this study was to describe the management and maternal-fetal prognosis of sickle cell disease during pregnancy and childbirth. Patients and methods: This was a prospective longitudinal descriptive study conducted over 12 months (1 January to 31 December 2022) in the gynaecology-obstetrics department of the Bernard Kouchner community medical centre in Coronthie, Conakry (Guinea). Pregnant women were included following diagnostic confirmation of sickle cell disease by haemoglobin electrophoresis. Results: During the study period, 43 (8.1%) of the 533 pregnant women attending antenatal clinics met our inclusion criteria. The mean age was 27.83 years, with extremes of 16 and 40 years. Professional women were the most affected (41.8%). Primiparous women and women with no schooling represented 51.2% and 39.5% of our study population respectively. The medical and obstetric history was dominated by vaso-occlusive crises (46.5%), followed by anaemia (23.2%), miscarriage (11.6%), genital infections (6.9%) and foetal death in utero (4.7%). We noted three types of sickle cell phenotype with varying proportions: the AS phenotype (65%), the SC phenotype (23%) and the SS phenotype (12%). Complications were mainly anaemia (27.9%), vaso-occlusive crises (13.9%), retroplacental haematoma (6.9%), premature rupture of membranes (6.9%), urinary tract infection (4, 6%), hypertension (2.3%), acute foetal distress (11.6%), hypotrophy (4.7), intrapartum foetal death (4.7%), in-utero foetal death (2.3%) and intrauterine growth retardation (2.3%). Conclusion: Sickle cell disease in pregnant women is common in our context and often leads to maternal and perinatal complications. The Emmel test should be performed systematically at each first antenatal consultation, along with haemoglobin electrophoresis.
    },
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Maternal-Fetal Prognosis of Pregnancy and Childbirth in Sickle-Cell Patients at the Bernard Kouchner Community Medical Centre of Coronthie in Conakry (Guinea)
    AU  - Tolno Tamba Julien
    AU  - Leno Daniel William Athanase
    AU  - Balde Maimouna
    AU  - Toure Souleymane
    AU  - Camara Moussa
    AU  - Tolno Pascal
    AU  - Bangoura Salematou
    AU  - Diallo Abdourahamane
    AU  - Sy Telly
    AU  - Hyjazi Yolande
    AU  - Keita Namory
    Y1  - 2023/12/11
    PY  - 2023
    N1  - https://doi.org/10.11648/j.cajph.20230906.12
    DO  - 10.11648/j.cajph.20230906.12
    T2  - Central African Journal of Public Health
    JF  - Central African Journal of Public Health
    JO  - Central African Journal of Public Health
    SP  - 167
    EP  - 171
    PB  - Science Publishing Group
    SN  - 2575-5781
    UR  - https://doi.org/10.11648/j.cajph.20230906.12
    AB  - Introduction: Sickle cell anaemia is an autosomal recessive inherited haemoglobin disorder caused by the presence of high concentrations of abnormal haemoglobin, haemoglobin S, in the red blood cell. Pregnancy is not contraindicated in women with sickle cell disease, but it is a high-risk situation for both mother and foetus. Observed maternal mortality varies from 0.5 to 5%. The aim of this study was to describe the management and maternal-fetal prognosis of sickle cell disease during pregnancy and childbirth. Patients and methods: This was a prospective longitudinal descriptive study conducted over 12 months (1 January to 31 December 2022) in the gynaecology-obstetrics department of the Bernard Kouchner community medical centre in Coronthie, Conakry (Guinea). Pregnant women were included following diagnostic confirmation of sickle cell disease by haemoglobin electrophoresis. Results: During the study period, 43 (8.1%) of the 533 pregnant women attending antenatal clinics met our inclusion criteria. The mean age was 27.83 years, with extremes of 16 and 40 years. Professional women were the most affected (41.8%). Primiparous women and women with no schooling represented 51.2% and 39.5% of our study population respectively. The medical and obstetric history was dominated by vaso-occlusive crises (46.5%), followed by anaemia (23.2%), miscarriage (11.6%), genital infections (6.9%) and foetal death in utero (4.7%). We noted three types of sickle cell phenotype with varying proportions: the AS phenotype (65%), the SC phenotype (23%) and the SS phenotype (12%). Complications were mainly anaemia (27.9%), vaso-occlusive crises (13.9%), retroplacental haematoma (6.9%), premature rupture of membranes (6.9%), urinary tract infection (4, 6%), hypertension (2.3%), acute foetal distress (11.6%), hypotrophy (4.7), intrapartum foetal death (4.7%), in-utero foetal death (2.3%) and intrauterine growth retardation (2.3%). Conclusion: Sickle cell disease in pregnant women is common in our context and often leads to maternal and perinatal complications. The Emmel test should be performed systematically at each first antenatal consultation, along with haemoglobin electrophoresis.
    
    VL  - 9
    IS  - 6
    ER  - 

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Author Information
  • Gynaecology and Obstetrics Department, Ignace DEEN National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

  • Gynaeco-Obstetrics Department, Donka National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

  • Gynaecology and Obstetrics Department, Ignace DEEN National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

  • Gynaeco-Obstetrics Department, Donka National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

  • Gynaecology and Obstetrics Department, Ignace DEEN National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

  • Gynaecology and Obstetrics Department, Ignace DEEN National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

  • Gynaecology and Obstetrics Department, Ignace DEEN National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

  • Gynaecology and Obstetrics Department, Ignace DEEN National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

  • Gynaecology and Obstetrics Department, Ignace DEEN National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

  • Gynaeco-Obstetrics Department, Donka National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

  • Gynaeco-Obstetrics Department, Donka National Hospital, Conakry University Hospital, Gamal Abdel Nasser University, Conakry, Rep. of Guinea

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