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Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride

Received: 29 May 2013     Published: 20 June 2013
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Abstract

The optimization of the synthesis of anti-tuberculosis drug by thia-Michael addition between thiophenol and chalcone catalyzed using activated Fluorapatite supported potassium fluoride (KF/FAP) was studied using a 2 block central composite design including 4 factors (reaction time, solvent volume, catalyst weight and impregnation ratio). The high reactivity and regioelectivity of our catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.

Published in American Journal of Theoretical and Applied Statistics (Volume 2, Issue 3)
DOI 10.11648/j.ajtas.20130203.16
Page(s) 81-86
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

References
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[6] Y. Abrouki, M. Zahouily, A. Rayadh, B. Bahlaouan, S. Sebti, A natural phosphate and doped-catalyzed Michael addition of mercaptans to α,β-unsaturated carbonyl compounds, Tet. Lett., 43, (2002), pp. 8951-8953.
[7] M. Ceylan, M. B. Gürdere, H. Gezegen, Y. Budak, Potassium-tertiary butoxide-assisted Addition of thioglycolic acid to chalcone derivatives under solvent-free conditions, Synt. Commun., 40 (2010), pp. 2598-2606.
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[10] Y. Riadi, R. Mamouni, Y. Abrouki, M. El Haddad, N. Saffaj, S. El Antri, S. Routier, G. Guillaumet, S. Lazar, Animal Bone Meal (ABM): A Novel Natural Catalyst for Thia-Michael Addition, Tet. Lett., 51, (2010), pp. 6715-6717.
[11] M. Zahouily, Y. Abrouki, A. Rayadh, S. Sebti, H. Dhimane, and M. David, Fluorapatite: efficient catalyst for the Michael addition, Tet. Lett. 44, (2003), pp. 2463-2465.
[12] Smahi, A. Solhy, H. El Badaoui, A. Amoukal, A. Tikad, M. Maizi, and S. Sebti, Potassium fluoride doped fluorapatite and hydroxyapatite as new catalysts in organic synthesis Appl. Catal. A. Gen., 250, (2003), pp. 151-159.
[13] Anouzla, Y. Abrouki, S. Souabi, M. Safi, H. Rhbal, Colour and COD removal of disperse Dye solution by a novel Coagulant: Application of statistical Design for the optimization and Regression analysis, J. Hazard. Mater., 166 (2009), pp. 1302-1306.
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  • APA Style

    Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaâ Lotfi, Ahmed Rayadh, et al. (2013). Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride. American Journal of Theoretical and Applied Statistics, 2(3), 81-86. https://doi.org/10.11648/j.ajtas.20130203.16

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    ACS Style

    Younes Abrouki; Abdelkader Anouzla; Hayat Loukili; Rabiaâ Lotfi; Ahmed Rayadh, et al. Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride. Am. J. Theor. Appl. Stat. 2013, 2(3), 81-86. doi: 10.11648/j.ajtas.20130203.16

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    AMA Style

    Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaâ Lotfi, Ahmed Rayadh, et al. Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride. Am J Theor Appl Stat. 2013;2(3):81-86. doi: 10.11648/j.ajtas.20130203.16

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  • @article{10.11648/j.ajtas.20130203.16,
      author = {Younes Abrouki and Abdelkader Anouzla and Hayat Loukili and Rabiaâ Lotfi and Ahmed Rayadh and Abdellah Bahlaoui and Saı̈d Sebti and Driss Zakarya and Mohamed Zahouily},
      title = {Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride},
      journal = {American Journal of Theoretical and Applied Statistics},
      volume = {2},
      number = {3},
      pages = {81-86},
      doi = {10.11648/j.ajtas.20130203.16},
      url = {https://doi.org/10.11648/j.ajtas.20130203.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajtas.20130203.16},
      abstract = {The optimization of the synthesis of anti-tuberculosis drug by thia-Michael addition between thiophenol and chalcone catalyzed using activated Fluorapatite supported potassium fluoride (KF/FAP) was studied using a 2 block central composite design including 4 factors (reaction time, solvent volume, catalyst weight and impregnation ratio). The high reactivity and regioelectivity of our catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.},
     year = {2013}
    }
    

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    T1  - Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride
    AU  - Younes Abrouki
    AU  - Abdelkader Anouzla
    AU  - Hayat Loukili
    AU  - Rabiaâ Lotfi
    AU  - Ahmed Rayadh
    AU  - Abdellah Bahlaoui
    AU  - Saı̈d Sebti
    AU  - Driss Zakarya
    AU  - Mohamed Zahouily
    Y1  - 2013/06/20
    PY  - 2013
    N1  - https://doi.org/10.11648/j.ajtas.20130203.16
    DO  - 10.11648/j.ajtas.20130203.16
    T2  - American Journal of Theoretical and Applied Statistics
    JF  - American Journal of Theoretical and Applied Statistics
    JO  - American Journal of Theoretical and Applied Statistics
    SP  - 81
    EP  - 86
    PB  - Science Publishing Group
    SN  - 2326-9006
    UR  - https://doi.org/10.11648/j.ajtas.20130203.16
    AB  - The optimization of the synthesis of anti-tuberculosis drug by thia-Michael addition between thiophenol and chalcone catalyzed using activated Fluorapatite supported potassium fluoride (KF/FAP) was studied using a 2 block central composite design including 4 factors (reaction time, solvent volume, catalyst weight and impregnation ratio). The high reactivity and regioelectivity of our catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.
    VL  - 2
    IS  - 3
    ER  - 

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Author Information
  • Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco

  • Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco

  • Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco

  • Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco

  • Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco

  • Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco

  • Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco

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