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Green Protocol for the Synthesis of Catalyst Free Biginelli Products

Received: 5 September 2019     Accepted: 26 April 2020     Published: 28 May 2020
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Abstract

Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employed multicomponent Biginelli reaction to synthesis range of different dihydropyrimidones (-thiones) derivatives in variable yields. A solvent-free eco-friendly green protocol without any expensive catalyst has been optimized and expand to synthesize series of DHMPS in 34 to 72% yield. The optimized method proved to be successful with various types of different aromatic aldehydes, 1, 3-dicarbonyl compounds and urea (thiourea) under solvent and catalyst free condition to access dihydropyrimidones (­thiones). Different spectroscopic techniques include NMR, FTIR etc. have used to confirm the structures of compounds. Further exploration of Biginelli reaction to prepare DHPMs and related compounds is under way in the lab and will be published in due course.

Published in American Journal of Heterocyclic Chemistry (Volume 6, Issue 1)
DOI 10.11648/j.ajhc.20200601.11
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Green Chemistry, 3, 4-Dihydropyrimidones, 3, 4-Dihydropyrimidothiones, Multi Component, Synthetic Methods, One pot, Catalyst Free Reactions

References
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Cite This Article
  • APA Style

    Abdul Ghafoor, Naved Sajid, Muhammad Adnan, Muhammad Naeem Khan, Amin Abid, et al. (2020). Green Protocol for the Synthesis of Catalyst Free Biginelli Products. American Journal of Heterocyclic Chemistry, 6(1), 1-5. https://doi.org/10.11648/j.ajhc.20200601.11

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    ACS Style

    Abdul Ghafoor; Naved Sajid; Muhammad Adnan; Muhammad Naeem Khan; Amin Abid, et al. Green Protocol for the Synthesis of Catalyst Free Biginelli Products. Am. J. Heterocycl. Chem. 2020, 6(1), 1-5. doi: 10.11648/j.ajhc.20200601.11

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    AMA Style

    Abdul Ghafoor, Naved Sajid, Muhammad Adnan, Muhammad Naeem Khan, Amin Abid, et al. Green Protocol for the Synthesis of Catalyst Free Biginelli Products. Am J Heterocycl Chem. 2020;6(1):1-5. doi: 10.11648/j.ajhc.20200601.11

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  • @article{10.11648/j.ajhc.20200601.11,
      author = {Abdul Ghafoor and Naved Sajid and Muhammad Adnan and Muhammad Naeem Khan and Amin Abid and Ansa Madeeha Zafar and Muhammad Ahmad and Noreen Aslam and Mussarat Jabeen and Amjad Ali and Misbahul Ain Khan},
      title = {Green Protocol for the Synthesis of Catalyst Free Biginelli Products},
      journal = {American Journal of Heterocyclic Chemistry},
      volume = {6},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.ajhc.20200601.11},
      url = {https://doi.org/10.11648/j.ajhc.20200601.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20200601.11},
      abstract = {Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employed multicomponent Biginelli reaction to synthesis range of different dihydropyrimidones (-thiones) derivatives in variable yields. A solvent-free eco-friendly green protocol without any expensive catalyst has been optimized and expand to synthesize series of DHMPS in 34 to 72% yield. The optimized method proved to be successful with various types of different aromatic aldehydes, 1, 3-dicarbonyl compounds and urea (thiourea) under solvent and catalyst free condition to access dihydropyrimidones (­thiones). Different spectroscopic techniques include NMR, FTIR etc. have used to confirm the structures of compounds. Further exploration of Biginelli reaction to prepare DHPMs and related compounds is under way in the lab and will be published in due course.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Green Protocol for the Synthesis of Catalyst Free Biginelli Products
    AU  - Abdul Ghafoor
    AU  - Naved Sajid
    AU  - Muhammad Adnan
    AU  - Muhammad Naeem Khan
    AU  - Amin Abid
    AU  - Ansa Madeeha Zafar
    AU  - Muhammad Ahmad
    AU  - Noreen Aslam
    AU  - Mussarat Jabeen
    AU  - Amjad Ali
    AU  - Misbahul Ain Khan
    Y1  - 2020/05/28
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ajhc.20200601.11
    DO  - 10.11648/j.ajhc.20200601.11
    T2  - American Journal of Heterocyclic Chemistry
    JF  - American Journal of Heterocyclic Chemistry
    JO  - American Journal of Heterocyclic Chemistry
    SP  - 1
    EP  - 5
    PB  - Science Publishing Group
    SN  - 2575-5722
    UR  - https://doi.org/10.11648/j.ajhc.20200601.11
    AB  - Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employed multicomponent Biginelli reaction to synthesis range of different dihydropyrimidones (-thiones) derivatives in variable yields. A solvent-free eco-friendly green protocol without any expensive catalyst has been optimized and expand to synthesize series of DHMPS in 34 to 72% yield. The optimized method proved to be successful with various types of different aromatic aldehydes, 1, 3-dicarbonyl compounds and urea (thiourea) under solvent and catalyst free condition to access dihydropyrimidones (­thiones). Different spectroscopic techniques include NMR, FTIR etc. have used to confirm the structures of compounds. Further exploration of Biginelli reaction to prepare DHPMs and related compounds is under way in the lab and will be published in due course.
    VL  - 6
    IS  - 1
    ER  - 

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Author Information
  • Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan

  • Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

  • Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

  • Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan

  • Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan

  • Department of Chemistry, The Women University, Bahawalpur, Pakistan

  • Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan

  • Department of Chemistry, The Women University, Bahawalpur, Pakistan

  • Department of Chemistry, The Women University, Bahawalpur, Pakistan

  • Department of Anatomy, CMH Institute of Medical Sciences, Multan, Pakistan

  • Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

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