In present paper, we report the organic syntheses of three compounds exactly 4-hydroxy-chromen-2-one and describe the results of antibacterial activity of purified compounds. Compounds 4-(4-Methoxy-phenylamino)-2-oxo-2H-chromene-3-sulfonyl chloride (a). N-{3-[Diethoxy-(2-hydroxy-phenyl)-methyl]-2-oxo-2H-chromen-4-yl}-acetamide (b), 4-(6-Nitro-benzothiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (c), have been synthesized and characterized using melting points, IR spectra, 1H-NMR and 13C-NMR spectra. Our research goal is synthesis novel organic compounds which prove high level of antibacterial activity. The antibacterial activity of synthesized compounds and streptomycin and cefalexine at concentrations of 2mg/ml, 3mg/ml and 5mg/ml, have been evaluated against three strains of bacterial culture; Staphylococcus aureus, E. coli and Bacillus cereus. The compounds show bacteriostatic and bactericidal activity in high level and also synthetized compounds has been characterized using advanced instrumental methods of analysis.
| Published in | American Journal of Heterocyclic Chemistry (Volume 5, Issue 1) |
| DOI | 10.11648/j.ajhc.20190501.13 |
| Page(s) | 7-10 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Coumarine Derivatives, Antibacterial Activity, IR, 1H-NM, 13C-NMR, Streptomycine
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APA Style
Aziz Behrami, Florent Dobroshi. (2019). Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One. American Journal of Heterocyclic Chemistry, 5(1), 7-10. https://doi.org/10.11648/j.ajhc.20190501.13
ACS Style
Aziz Behrami; Florent Dobroshi. Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One. Am. J. Heterocycl. Chem. 2019, 5(1), 7-10. doi: 10.11648/j.ajhc.20190501.13
AMA Style
Aziz Behrami, Florent Dobroshi. Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One. Am J Heterocycl Chem. 2019;5(1):7-10. doi: 10.11648/j.ajhc.20190501.13
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Download@article{10.11648/j.ajhc.20190501.13,
author = {Aziz Behrami and Florent Dobroshi},
title = {Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One},
journal = {American Journal of Heterocyclic Chemistry},
volume = {5},
number = {1},
pages = {7-10},
doi = {10.11648/j.ajhc.20190501.13},
url = {https://doi.org/10.11648/j.ajhc.20190501.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20190501.13},
abstract = {In present paper, we report the organic syntheses of three compounds exactly 4-hydroxy-chromen-2-one and describe the results of antibacterial activity of purified compounds. Compounds 4-(4-Methoxy-phenylamino)-2-oxo-2H-chromene-3-sulfonyl chloride (a). N-{3-[Diethoxy-(2-hydroxy-phenyl)-methyl]-2-oxo-2H-chromen-4-yl}-acetamide (b), 4-(6-Nitro-benzothiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (c), have been synthesized and characterized using melting points, IR spectra, 1H-NMR and 13C-NMR spectra. Our research goal is synthesis novel organic compounds which prove high level of antibacterial activity. The antibacterial activity of synthesized compounds and streptomycin and cefalexine at concentrations of 2mg/ml, 3mg/ml and 5mg/ml, have been evaluated against three strains of bacterial culture; Staphylococcus aureus, E. coli and Bacillus cereus. The compounds show bacteriostatic and bactericidal activity in high level and also synthetized compounds has been characterized using advanced instrumental methods of analysis.},
year = {2019}
}
TY - JOUR
T1 - Antibacterial Effects and Synthesized New Derivatives of 4-Hydroxy-Chromen-2-One
AU - Aziz Behrami
AU - Florent Dobroshi
Y1 - 2019/04/15
PY - 2019
N1 - https://doi.org/10.11648/j.ajhc.20190501.13
DO - 10.11648/j.ajhc.20190501.13
T2 - American Journal of Heterocyclic Chemistry
JF - American Journal of Heterocyclic Chemistry
JO - American Journal of Heterocyclic Chemistry
SP - 7
EP - 10
PB - Science Publishing Group
SN - 2575-5722
UR - https://doi.org/10.11648/j.ajhc.20190501.13
AB - In present paper, we report the organic syntheses of three compounds exactly 4-hydroxy-chromen-2-one and describe the results of antibacterial activity of purified compounds. Compounds 4-(4-Methoxy-phenylamino)-2-oxo-2H-chromene-3-sulfonyl chloride (a). N-{3-[Diethoxy-(2-hydroxy-phenyl)-methyl]-2-oxo-2H-chromen-4-yl}-acetamide (b), 4-(6-Nitro-benzothiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (c), have been synthesized and characterized using melting points, IR spectra, 1H-NMR and 13C-NMR spectra. Our research goal is synthesis novel organic compounds which prove high level of antibacterial activity. The antibacterial activity of synthesized compounds and streptomycin and cefalexine at concentrations of 2mg/ml, 3mg/ml and 5mg/ml, have been evaluated against three strains of bacterial culture; Staphylococcus aureus, E. coli and Bacillus cereus. The compounds show bacteriostatic and bactericidal activity in high level and also synthetized compounds has been characterized using advanced instrumental methods of analysis.
VL - 5
IS - 1
ER -
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