The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review

Md. Ashraful Alam; Kazuaki Shimada; Aklima Jahan; Dina Nasrin; Md. Kudrat-E-Zahan; Mohammad Shahabuddin

doi:doi:10.11648/j.ajhc.20170305.11

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The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review

Md. Ashraful Alam, Kazuaki Shimada, Aklima Jahan, Dina Nasrin, Md. Kudrat-E-Zahan, Mohammad Shahabuddin

Published in American Journal of Heterocyclic Chemistry (Volume 3, Issue 5)

Received: 6 September 2017 Accepted: 21 September 2017 Published: 23 October 2017

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Abstract

The aryne and its intermediates or their precursors are the most important compounds in organic synthesis for the purpose of arynes or benzyne insertion in many reactions. Arynes are among the first reactive intermediates known to organic chemists. Since their discovery, they have fascinated chemists from both theoretical and synthetic perspectives. These remarkable intermediates possess a wide reactivity profile, engaging in the different types of reactions especially in organic chemistry fields like nucleophilic addition reactions, pericyclic reactions, [4+2] and [3+2] cycloaddition reactions and transition metal-mediated/catalyzed reactions. This methodology would also be applicable for the synthesis of biologically and pharmaceutically active products such as isocoumarins, benzodiazepines and other important compounds in one pot reactions.

Published in	American Journal of Heterocyclic Chemistry (Volume 3, Issue 5)
DOI	10.11648/j.ajhc.20170305.11
Page(s)	47-54
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Arynes, Benzyne, Cycloaddition Reactions, Heterocycles, Isocoumarins, Nucleophilic Reactions, Pericyclic Reactions

References

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Md. Ashraful Alam, Kazuaki Shimada, Aklima Jahan, Dina Nasrin, Md. Kudrat-E-Zahan, et al. (2017). The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review. American Journal of Heterocyclic Chemistry, 3(5), 47-54. https://doi.org/10.11648/j.ajhc.20170305.11

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Md. Ashraful Alam; Kazuaki Shimada; Aklima Jahan; Dina Nasrin; Md. Kudrat-E-Zahan, et al. The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review. Am. J. Heterocycl. Chem. 2017, 3(5), 47-54. doi: 10.11648/j.ajhc.20170305.11

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AMA Style

Md. Ashraful Alam, Kazuaki Shimada, Aklima Jahan, Dina Nasrin, Md. Kudrat-E-Zahan, et al. The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review. Am J Heterocycl Chem. 2017;3(5):47-54. doi: 10.11648/j.ajhc.20170305.11

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@article{10.11648/j.ajhc.20170305.11,
  author = {Md. Ashraful Alam and Kazuaki Shimada and Aklima Jahan and Dina Nasrin and Md. Kudrat-E-Zahan and Mohammad Shahabuddin},
  title = {The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review},
  journal = {American Journal of Heterocyclic Chemistry},
  volume = {3},
  number = {5},
  pages = {47-54},
  doi = {10.11648/j.ajhc.20170305.11},
  url = {https://doi.org/10.11648/j.ajhc.20170305.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20170305.11},
  abstract = {The aryne and its intermediates or their precursors are the most important compounds in organic synthesis for the purpose of arynes or benzyne insertion in many reactions. Arynes are among the first reactive intermediates known to organic chemists. Since their discovery, they have fascinated chemists from both theoretical and synthetic perspectives. These remarkable intermediates possess a wide reactivity profile, engaging in the different types of reactions especially in organic chemistry fields like nucleophilic addition reactions, pericyclic reactions, [4+2] and [3+2] cycloaddition reactions and transition metal-mediated/catalyzed reactions. This methodology would also be applicable for the synthesis of biologically and pharmaceutically active products such as isocoumarins, benzodiazepines and other important compounds in one pot reactions.},
 year = {2017}
}

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TY  - JOUR
T1  - The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review
AU  - Md. Ashraful Alam
AU  - Kazuaki Shimada
AU  - Aklima Jahan
AU  - Dina Nasrin
AU  - Md. Kudrat-E-Zahan
AU  - Mohammad Shahabuddin
Y1  - 2017/10/23
PY  - 2017
N1  - https://doi.org/10.11648/j.ajhc.20170305.11
DO  - 10.11648/j.ajhc.20170305.11
T2  - American Journal of Heterocyclic Chemistry
JF  - American Journal of Heterocyclic Chemistry
JO  - American Journal of Heterocyclic Chemistry
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EP  - 54
PB  - Science Publishing Group
SN  - 2575-5722
UR  - https://doi.org/10.11648/j.ajhc.20170305.11
AB  - The aryne and its intermediates or their precursors are the most important compounds in organic synthesis for the purpose of arynes or benzyne insertion in many reactions. Arynes are among the first reactive intermediates known to organic chemists. Since their discovery, they have fascinated chemists from both theoretical and synthetic perspectives. These remarkable intermediates possess a wide reactivity profile, engaging in the different types of reactions especially in organic chemistry fields like nucleophilic addition reactions, pericyclic reactions, [4+2] and [3+2] cycloaddition reactions and transition metal-mediated/catalyzed reactions. This methodology would also be applicable for the synthesis of biologically and pharmaceutically active products such as isocoumarins, benzodiazepines and other important compounds in one pot reactions.
VL  - 3
IS  - 5
ER  -

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Author Information

Md. Ashraful Alam

Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
Kazuaki Shimada

Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
Aklima Jahan

Department of Chemistry, University of Chittagong, Chittagong, Bangladesh
Dina Nasrin

Department of Chemistry, Bangladesh University of Engineering and Technology (BUET), Dhaka, Bangladesh
Md. Kudrat-E-Zahan

Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Mohammad Shahabuddin

Department of Chemistry, Shahjalal University of Science and Technology (SUST), Sylhet, Bangladesh

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Md. Ashraful Alam, Kazuaki Shimada, Aklima Jahan, Dina Nasrin, Md. Kudrat-E-Zahan, et al. (2017). The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review. American Journal of Heterocyclic Chemistry, 3(5), 47-54. https://doi.org/10.11648/j.ajhc.20170305.11

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Md. Ashraful Alam; Kazuaki Shimada; Aklima Jahan; Dina Nasrin; Md. Kudrat-E-Zahan, et al. The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review. Am. J. Heterocycl. Chem. 2017, 3(5), 47-54. doi: 10.11648/j.ajhc.20170305.11

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AMA Style

Md. Ashraful Alam, Kazuaki Shimada, Aklima Jahan, Dina Nasrin, Md. Kudrat-E-Zahan, et al. The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review. Am J Heterocycl Chem. 2017;3(5):47-54. doi: 10.11648/j.ajhc.20170305.11

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@article{10.11648/j.ajhc.20170305.11,
  author = {Md. Ashraful Alam and Kazuaki Shimada and Aklima Jahan and Dina Nasrin and Md. Kudrat-E-Zahan and Mohammad Shahabuddin},
  title = {The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review},
  journal = {American Journal of Heterocyclic Chemistry},
  volume = {3},
  number = {5},
  pages = {47-54},
  doi = {10.11648/j.ajhc.20170305.11},
  url = {https://doi.org/10.11648/j.ajhc.20170305.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20170305.11},
  abstract = {The aryne and its intermediates or their precursors are the most important compounds in organic synthesis for the purpose of arynes or benzyne insertion in many reactions. Arynes are among the first reactive intermediates known to organic chemists. Since their discovery, they have fascinated chemists from both theoretical and synthetic perspectives. These remarkable intermediates possess a wide reactivity profile, engaging in the different types of reactions especially in organic chemistry fields like nucleophilic addition reactions, pericyclic reactions, [4+2] and [3+2] cycloaddition reactions and transition metal-mediated/catalyzed reactions. This methodology would also be applicable for the synthesis of biologically and pharmaceutically active products such as isocoumarins, benzodiazepines and other important compounds in one pot reactions.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review
AU  - Md. Ashraful Alam
AU  - Kazuaki Shimada
AU  - Aklima Jahan
AU  - Dina Nasrin
AU  - Md. Kudrat-E-Zahan
AU  - Mohammad Shahabuddin
Y1  - 2017/10/23
PY  - 2017
N1  - https://doi.org/10.11648/j.ajhc.20170305.11
DO  - 10.11648/j.ajhc.20170305.11
T2  - American Journal of Heterocyclic Chemistry
JF  - American Journal of Heterocyclic Chemistry
JO  - American Journal of Heterocyclic Chemistry
SP  - 47
EP  - 54
PB  - Science Publishing Group
SN  - 2575-5722
UR  - https://doi.org/10.11648/j.ajhc.20170305.11
AB  - The aryne and its intermediates or their precursors are the most important compounds in organic synthesis for the purpose of arynes or benzyne insertion in many reactions. Arynes are among the first reactive intermediates known to organic chemists. Since their discovery, they have fascinated chemists from both theoretical and synthetic perspectives. These remarkable intermediates possess a wide reactivity profile, engaging in the different types of reactions especially in organic chemistry fields like nucleophilic addition reactions, pericyclic reactions, [4+2] and [3+2] cycloaddition reactions and transition metal-mediated/catalyzed reactions. This methodology would also be applicable for the synthesis of biologically and pharmaceutically active products such as isocoumarins, benzodiazepines and other important compounds in one pot reactions.
VL  - 3
IS  - 5
ER  -

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