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The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review

Received: 6 September 2017     Accepted: 21 September 2017     Published: 23 October 2017
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Abstract

The aryne and its intermediates or their precursors are the most important compounds in organic synthesis for the purpose of arynes or benzyne insertion in many reactions. Arynes are among the first reactive intermediates known to organic chemists. Since their discovery, they have fascinated chemists from both theoretical and synthetic perspectives. These remarkable intermediates possess a wide reactivity profile, engaging in the different types of reactions especially in organic chemistry fields like nucleophilic addition reactions, pericyclic reactions, [4+2] and [3+2] cycloaddition reactions and transition metal-mediated/catalyzed reactions. This methodology would also be applicable for the synthesis of biologically and pharmaceutically active products such as isocoumarins, benzodiazepines and other important compounds in one pot reactions.

Published in American Journal of Heterocyclic Chemistry (Volume 3, Issue 5)
DOI 10.11648/j.ajhc.20170305.11
Page(s) 47-54
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Arynes, Benzyne, Cycloaddition Reactions, Heterocycles, Isocoumarins, Nucleophilic Reactions, Pericyclic Reactions

References
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    Md. Ashraful Alam, Kazuaki Shimada, Aklima Jahan, Dina Nasrin, Md. Kudrat-E-Zahan, et al. (2017). The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review. American Journal of Heterocyclic Chemistry, 3(5), 47-54. https://doi.org/10.11648/j.ajhc.20170305.11

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    Md. Ashraful Alam; Kazuaki Shimada; Aklima Jahan; Dina Nasrin; Md. Kudrat-E-Zahan, et al. The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review. Am. J. Heterocycl. Chem. 2017, 3(5), 47-54. doi: 10.11648/j.ajhc.20170305.11

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    AMA Style

    Md. Ashraful Alam, Kazuaki Shimada, Aklima Jahan, Dina Nasrin, Md. Kudrat-E-Zahan, et al. The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review. Am J Heterocycl Chem. 2017;3(5):47-54. doi: 10.11648/j.ajhc.20170305.11

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  • @article{10.11648/j.ajhc.20170305.11,
      author = {Md. Ashraful Alam and Kazuaki Shimada and Aklima Jahan and Dina Nasrin and Md. Kudrat-E-Zahan and Mohammad Shahabuddin},
      title = {The Advances and Applications of Arynes and Their Precursors to Synthesize the Heterocyclic Compounds: A Review},
      journal = {American Journal of Heterocyclic Chemistry},
      volume = {3},
      number = {5},
      pages = {47-54},
      doi = {10.11648/j.ajhc.20170305.11},
      url = {https://doi.org/10.11648/j.ajhc.20170305.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20170305.11},
      abstract = {The aryne and its intermediates or their precursors are the most important compounds in organic synthesis for the purpose of arynes or benzyne insertion in many reactions. Arynes are among the first reactive intermediates known to organic chemists. Since their discovery, they have fascinated chemists from both theoretical and synthetic perspectives. These remarkable intermediates possess a wide reactivity profile, engaging in the different types of reactions especially in organic chemistry fields like nucleophilic addition reactions, pericyclic reactions, [4+2] and [3+2] cycloaddition reactions and transition metal-mediated/catalyzed reactions. This methodology would also be applicable for the synthesis of biologically and pharmaceutically active products such as isocoumarins, benzodiazepines and other important compounds in one pot reactions.},
     year = {2017}
    }
    

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    AU  - Md. Ashraful Alam
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    AU  - Dina Nasrin
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    Y1  - 2017/10/23
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    N1  - https://doi.org/10.11648/j.ajhc.20170305.11
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    T2  - American Journal of Heterocyclic Chemistry
    JF  - American Journal of Heterocyclic Chemistry
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    AB  - The aryne and its intermediates or their precursors are the most important compounds in organic synthesis for the purpose of arynes or benzyne insertion in many reactions. Arynes are among the first reactive intermediates known to organic chemists. Since their discovery, they have fascinated chemists from both theoretical and synthetic perspectives. These remarkable intermediates possess a wide reactivity profile, engaging in the different types of reactions especially in organic chemistry fields like nucleophilic addition reactions, pericyclic reactions, [4+2] and [3+2] cycloaddition reactions and transition metal-mediated/catalyzed reactions. This methodology would also be applicable for the synthesis of biologically and pharmaceutically active products such as isocoumarins, benzodiazepines and other important compounds in one pot reactions.
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Author Information
  • Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan

  • Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan

  • Department of Chemistry, University of Chittagong, Chittagong, Bangladesh

  • Department of Chemistry, Bangladesh University of Engineering and Technology (BUET), Dhaka, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, Shahjalal University of Science and Technology (SUST), Sylhet, Bangladesh

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