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Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection

Received: 24 December 2015     Published: 30 December 2015
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Abstract

To compare the pharmacokinetics and relative bioavailability of ambroxol hydrochloride (AH) aerosol and injection, the volunteers were subjected to single-dose crossover inhalation (injection) of 100 mg AH aerosol (injection). The drug concentrations in plasma were determined by HPLC. The areas under curve (AUC) of the two formulations were compared by the three-factor analysis of variance and the bi-directional one-side t test. The Cmax, tmax, t1/2β and AUC values of the aerosol group and the injection group were (154.75±26.12) and (157.39±26.09) ng/ml, (1.12±0.34) and (1.29±0.33) h, (6.98±1.62) and (7.75±1.26) h, and (1593.02±290.45) and (1438±132.46) h•ng/ml, respectively. The bioavailabilities of AH aerosol and injection were the same, and the relative bioavailability of the aerosol was (96.52±11.44)%.

Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 6)
DOI 10.11648/j.ajcem.20150306.18
Page(s) 368-371
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Ambroxol Hydrochloride, Bioavailability, Pharmacokinetics, HPLC

References
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[2] Wiessmann KJ, Niemeyer K (1978) [Clinical results in the treatment of chronic obstructive bronchitis with ambroxol in comparison with bromhexine (author's transl)]. Arzneimittelforschung 28(5a): 918-921.
[3] Lee HJ, Joung SK, Kim YG, Yoo JY, Han SB (2004) Bioequivalence assessment of ambroxol tablet after a single oral dose administration to healthy male volunteers. Pharmacol Res 49(1): 93-98.
[4] Ren YC, Wang L, He HB, Tang X (2009) Pulmonary selectivity and local pharmacokinetics of ambroxol hydrochloride dry powder inhalation in rat. J Pharm Sci 98(5): 1797-1803.
[5] Ballantyne BT, O'Hare SJ, Paschall JL, et al. (1993) Electromyographic activity of selected shoulder muscles in commonly used therapeutic exercises. Phys Ther 73(10): 668-677; discussion 677-682.
[6] Amantea M, Newman MS, Sullivan TM, Forrest A, Working PK (1999) Relationship of dose intensity to the induction of palmar-plantar erythrodysesthia by pegylated liposomal doxorubicin in dogs. Hum Exp Toxicol 18(1): 17-26.
[7] Rutland BE, Nachreiner RF, Kruger JM (2009) Optimal testing for thyroid hormone concentration after treatment with methimazole in healthy and hyperthyroid cats. J Vet Intern Med 23(5): 1025-1030.
[8] Yuen O, Caligiuri MP, Williams R, Dickson RA (1996) Tardive dyskinesia and positive and negative symptoms of schizophrenia. A study using instrumental measures. Br J Psychiatry 168(6): 702-708.
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[10] Villacampa J, Alcántar F, Rodríguez JM, Morales JM, Herrera J, Rosete R (2003) Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men. Clin Ther 25(8): 2225-2232.
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  • APA Style

    Jing Zhang, Na Yi, Lidao Bao, Tengfei Yu. (2015). Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection. American Journal of Clinical and Experimental Medicine, 3(6), 368-371. https://doi.org/10.11648/j.ajcem.20150306.18

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    ACS Style

    Jing Zhang; Na Yi; Lidao Bao; Tengfei Yu. Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection. Am. J. Clin. Exp. Med. 2015, 3(6), 368-371. doi: 10.11648/j.ajcem.20150306.18

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    AMA Style

    Jing Zhang, Na Yi, Lidao Bao, Tengfei Yu. Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection. Am J Clin Exp Med. 2015;3(6):368-371. doi: 10.11648/j.ajcem.20150306.18

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  • @article{10.11648/j.ajcem.20150306.18,
      author = {Jing Zhang and Na Yi and Lidao Bao and Tengfei Yu},
      title = {Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {3},
      number = {6},
      pages = {368-371},
      doi = {10.11648/j.ajcem.20150306.18},
      url = {https://doi.org/10.11648/j.ajcem.20150306.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150306.18},
      abstract = {To compare the pharmacokinetics and relative bioavailability of ambroxol hydrochloride (AH) aerosol and injection, the volunteers were subjected to single-dose crossover inhalation (injection) of 100 mg AH aerosol (injection). The drug concentrations in plasma were determined by HPLC. The areas under curve (AUC) of the two formulations were compared by the three-factor analysis of variance and the bi-directional one-side t test. The Cmax, tmax, t1/2β and AUC values of the aerosol group and the injection group were (154.75±26.12) and (157.39±26.09) ng/ml, (1.12±0.34) and (1.29±0.33) h, (6.98±1.62) and (7.75±1.26) h, and (1593.02±290.45) and (1438±132.46) h•ng/ml, respectively. The bioavailabilities of AH aerosol and injection were the same, and the relative bioavailability of the aerosol was (96.52±11.44)%.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection
    AU  - Jing Zhang
    AU  - Na Yi
    AU  - Lidao Bao
    AU  - Tengfei Yu
    Y1  - 2015/12/30
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajcem.20150306.18
    DO  - 10.11648/j.ajcem.20150306.18
    T2  - American Journal of Clinical and Experimental Medicine
    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
    SP  - 368
    EP  - 371
    PB  - Science Publishing Group
    SN  - 2330-8133
    UR  - https://doi.org/10.11648/j.ajcem.20150306.18
    AB  - To compare the pharmacokinetics and relative bioavailability of ambroxol hydrochloride (AH) aerosol and injection, the volunteers were subjected to single-dose crossover inhalation (injection) of 100 mg AH aerosol (injection). The drug concentrations in plasma were determined by HPLC. The areas under curve (AUC) of the two formulations were compared by the three-factor analysis of variance and the bi-directional one-side t test. The Cmax, tmax, t1/2β and AUC values of the aerosol group and the injection group were (154.75±26.12) and (157.39±26.09) ng/ml, (1.12±0.34) and (1.29±0.33) h, (6.98±1.62) and (7.75±1.26) h, and (1593.02±290.45) and (1438±132.46) h•ng/ml, respectively. The bioavailabilities of AH aerosol and injection were the same, and the relative bioavailability of the aerosol was (96.52±11.44)%.
    VL  - 3
    IS  - 6
    ER  - 

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Author Information
  • School of Pharmacy, Inner Mongolia Medical University, Hohhot, China

  • School of Pharmacy, Inner Mongolia Medical University, Hohhot, China

  • School of Pharmacy, Inner Mongolia Medical University, Hohhot, China

  • School of Pharmacy, Inner Mongolia Medical University, Hohhot, China

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