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Antiulcer Effect of an Aqueous Extract of Syzygium aromaticum (Myrtaceae) Buds in Wistar Rats

The buds of Syzygium aromaticum (Myrtaceae) is used in traditional medicine in the treatment of gastric ulcer. This pathology affects approximately 10% of the world's population. The current study aims to verify the antiulcer effect of an aqueous extract of the buds of Syzygium aromaticum (EASA) in wistar rats. For this, the 1000 mg/kg B.W. dose of EASA was tested on gastric ulcer induced with (Eth/HCl/H2O) in rats compared to the effect of 20 mg/kg B.W. of Omeprazole for 14 days. Also, a phytochemical screening was carried out on this extract. After 3 days of ulcer induction, the ulceration index was 3 and the ulceration percentage was 100% in the stomachs of the rats. The results after 14 days of treatment with EASA show that the ulceration index and the percentage of ulceration are 0.5 and 8.83% against 0 for Omeprazole. The aqueous extract of Syzygium aromaticum therefore treats the induced ulcer at 91.17% against 100% for Omeprazole. These results are confirmed by observations of scars on histological sections on the fourteenth day. Phytochemical screening indicates that EASA contains sterols, polyterpenes and polyphenols, quinone compounds, alkaloids and gallic tannins. These results would justify the use of Syzygium aromaticum buds in traditional medicine in the treatment of gastric ulcer.

Phytochemical Screening, Syzygium aromaticum, Ulcer, Induction, Omeprazole

APA Style

Irié Bi Jean Sévérin, Kahou Bi Gohi Parfait, N’Doua Akouah Leatitia Rosemonde, Lehou Monnhéssea Flore Danielle, Zahoui Ouga Stanistlas, et al. (2023). Antiulcer Effect of an Aqueous Extract of Syzygium aromaticum (Myrtaceae) Buds in Wistar Rats. Advances in Applied Physiology, 8(1), 20-28. https://doi.org/10.11648/j.aap.20230801.14

ACS Style

Irié Bi Jean Sévérin; Kahou Bi Gohi Parfait; N’Doua Akouah Leatitia Rosemonde; Lehou Monnhéssea Flore Danielle; Zahoui Ouga Stanistlas, et al. Antiulcer Effect of an Aqueous Extract of Syzygium aromaticum (Myrtaceae) Buds in Wistar Rats. Adv. Appl. Physiol. 2023, 8(1), 20-28. doi: 10.11648/j.aap.20230801.14

AMA Style

Irié Bi Jean Sévérin, Kahou Bi Gohi Parfait, N’Doua Akouah Leatitia Rosemonde, Lehou Monnhéssea Flore Danielle, Zahoui Ouga Stanistlas, et al. Antiulcer Effect of an Aqueous Extract of Syzygium aromaticum (Myrtaceae) Buds in Wistar Rats. Adv Appl Physiol. 2023;8(1):20-28. doi: 10.11648/j.aap.20230801.14

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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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