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Comparison the Effects of Esomeprazole with the Combination of Esomeprazole and Baclofen in the Treatment of Infantile Gastroesophageal Reflux Disease
Fatemeh Naderi,
Hojatolah Jafari Fesharaki,
Mehrangiz Khanmoradi
Issue:
Volume 10, Issue 4, August 2022
Pages:
102-109
Received:
3 June 2022
Accepted:
8 July 2022
Published:
20 July 2022
DOI:
10.11648/j.ajbls.20221004.11
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Abstract: Gastro Esophageal Reflux Disease (GERD) is a common and chronic disease in children, especially in children under 2 years old. Proton pump inhibitors (PPIs) have been recommended as the effective therapy in GERD. Esomeprazole is a safe and tolerable PPI in pediatrics. Studies have also shown that Baclofen effectively reduces symptoms of GERD in adult, but there are limited studies in pediatric patients. Purpose: This study aimed to compare the effect of Esomeprazole and the combination of Esomeprazole and Baclofen in the treatment of infantile GERD and its related manifestations. Methods: In a randomized clinical trial study, 50 infants with GERD were selected and randomly assigned into two groups receiving Esomeprazole (1mg/kg, once daily for two weeks) or a combination of Esomeprazole (1mg/kg, once daily for two weeks) and baclofen (0.2 mg/kg, once daily for two weeks). Patients were evaluated for reflux symptoms before treatment as well as at one week, two weeks, four weeks, two months and three months after initiation of treatment. The rate of remission of reflux was also determined in two groups. Results: During three months of treatment, improvement of symptoms associated with reflux including sleep disturbance, refusal to eat, restlessness, impaired quality of life, frequency of waking, nausea and regurgitation in the group treated with Esomeprazole plus baclofen were more favorable than those treated with Esomeprazole alone. Conclusion: Addition of baclofen to Esomeprazole can improve reflux disease more rapidly and favorably in infants with GERD.
Abstract: Gastro Esophageal Reflux Disease (GERD) is a common and chronic disease in children, especially in children under 2 years old. Proton pump inhibitors (PPIs) have been recommended as the effective therapy in GERD. Esomeprazole is a safe and tolerable PPI in pediatrics. Studies have also shown that Baclofen effectively reduces symptoms of GERD in adu...
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The Expression of ASPH in Breast Cancer
Zhao Xiaofeng,
Qin Xuying,
Yin Linlin,
Chen Dong,
Zheng Juan
Issue:
Volume 10, Issue 4, August 2022
Pages:
110-115
Received:
19 June 2022
Accepted:
6 July 2022
Published:
28 July 2022
DOI:
10.11648/j.ajbls.20221004.12
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Abstract: Asparagine-betahydroxylase (ASPH) plays an important role in cell growth, differentiation, adhesion and migration. And ASPH is silent in adult tissues in normal. It expresses at very low levels or not expresses at all in most normal cells and tissues. High level of ASPH always be detected in aggressive tumor cells and it indicates worsened clinical prognosis. The expression of ASPH in paraffin-embedded tissue sections was detected by immunostaining. We analyzed the distributions and levels of ASPH by immunohistochemical staining in breast cancer. ASPH is expressed high in breast cancer. And we detected the expression of ASPH by Elisa in breast cancer cells (MCF7) and normal mammary epithelial cells (MCF10A). The level of ASPH is higher in MCF7 than MCF10A. In breast cancer, the ASPH positive cases are 15 of 34, and the positive rate is 44.1%. The higher grade cancer was associated with the higher levels of ASPH. And we found that the ASPH expression have relation to the expression of progesterone receptor (PR) and HER-2. Our study demonstrates that increased ASPH expression in breast cancer, and it has closed relation to the level of PR and HER-2. Therefore, ASPH may be closely related to the malignant degree and prognosis of breast cancer.
Abstract: Asparagine-betahydroxylase (ASPH) plays an important role in cell growth, differentiation, adhesion and migration. And ASPH is silent in adult tissues in normal. It expresses at very low levels or not expresses at all in most normal cells and tissues. High level of ASPH always be detected in aggressive tumor cells and it indicates worsened clinical...
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Assess Socio-Demographic Characteristics of Patients with GERD Symptoms
Mohammad Nadim Hasan,
Kabirul Hasan bin Rakib,
Mohammad Shafiqullah Akbar,
Mohammad Asaduzzaman
Issue:
Volume 10, Issue 4, August 2022
Pages:
116-118
Received:
7 August 2021
Accepted:
17 December 2021
Published:
29 July 2022
DOI:
10.11648/j.ajbls.20221004.13
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Abstract: Background: Despite a common disorder of gastro-esophageal reflux disease (GERD) in Bangladesh, population based data is unavailable. This epidemiological study was designed to determine the prevalence of GERD and its association with socio-demographic and lifestyle factors. Objective: The aim of the study was to assess socio-demographic characteristic of patients with GERD symptoms. Methods: The descriptive study was conducted in the department of Medicine of Mymensingh Medical College and Hospital, Mymensingh, Bangladesh to find out the Socio-Demographic Characteristic of Patients with GERD. 384 cases were randomly. Clinical examination and evaluation were done from October 2012 to April 2013. Statistical analysis of the results was obtained by using window-based computer software devised with Statistical Packages for Social Sciences (SPSS-22). Results: 384 populations were age frequency among total population 199 (51.82%) from 18-38 years, 130 (33.85%) from 39-59 years and 55 (14.32%) from 60 years of age and above. The study was seen that 188 (48.95%) were male and 196 (51.05%) were female. Among the study population of 384 cases 72 (18.75%) person had symptoms score more than 4, i.e. presence of GERD symptoms and 312 (81.85%) cases has symptoms score less than 4, i.e. absence of GERD symptoms. 13.88% GERD patient having history of taking tobacco leaf/battle nut/smoking, while only 10.25% general people having similar habit 4.16%. Conclusion: Young age in any form may be a risk for GERD. Need to concentrate about heart-burn which showed a major symptoms for both male and female. More concentration should be given on chronic cough for male of GERD patient.
Abstract: Background: Despite a common disorder of gastro-esophageal reflux disease (GERD) in Bangladesh, population based data is unavailable. This epidemiological study was designed to determine the prevalence of GERD and its association with socio-demographic and lifestyle factors. Objective: The aim of the study was to assess socio-demographic characteri...
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A Comparative Study of the Outcome of Hyperglyceamia and Normoglycaemia in Patients with ST-Segment Elevation Acute Myocardial Infarction
Musammat Sufia Akhter,
Mirza Abdul Kalam Mohiuddin,
Shamshad Khan,
Ratul Sakaobe Shefa,
Ayesha Mubashsbira Labiba
Issue:
Volume 10, Issue 4, August 2022
Pages:
119-124
Received:
6 September 2021
Accepted:
24 January 2022
Published:
29 July 2022
DOI:
10.11648/j.ajbls.20221004.14
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Abstract: Introduction: Acute myocardial infarction (AMI) is an important cause of acute emergencies and is on the rise in the developing countries like Bangladesh. Patients with hyperglyceamia are at more risk than non-diabetic patients. Hyperglyceamia is pre-diabetic state. Aim of the study: The aim of this study was to compare the outcome of hyperglyceamia and normoglycaemia in patients with ST-segment elevation Acute Myocardial Infarction. Methods: This prospective prognostic cohort research was conducted at the Department of Cardiology, NICVD, Dhaka from July 2010 to June 2011. Total 200 study populations were selected from the ST- segment elevation Acute Myocardial Infarction patients with or without history of DM. Result: In this study, number of patients improvement in group-1 was significantly (p < 0.01) higher 90 (90%), in group-2 was 73 (73%). But death (p<0.01) was more 27 (27%) in group-2 and in group-1 was 10 (10%). The number of patients developed morbidity like (Cardiogenic shock, Congestive cardiac failure, hypotension, Thromboembolism and arrhythmia) were less in group-1 (44%) but more common in group-2 (70%). The result was statistically very significant (p < 0.01). Number of patients improvement in group-1 was significantly (p < 0.001) higher 90 (90%) than in group II-A 31 (62%). But death (p < 0.001) was more 19 (38%) in group-2A than in group-1 10 (10%). The number of patients developed morbidity like (Cardiogenic shock, Congestive cardiac failure, hypotension, Thromboembolism and arrhythmia) were 44 (44%) in group-1 and 30 (60%). There was no statistical significance. Conclusion: There is difference in the in-hospital outcome of hyperglyceamia and normoglycaemia in patients with ST-segment elevation Acute Myocardial Infarction. Improvement and morbidity were higher in the normoglycaemia patients than hyperglyceamia patients and death rate is higher is the hyperglyceamia patients. But there is no difference in normoglycaemia and diabetic hyperglyceamia patients.
Abstract: Introduction: Acute myocardial infarction (AMI) is an important cause of acute emergencies and is on the rise in the developing countries like Bangladesh. Patients with hyperglyceamia are at more risk than non-diabetic patients. Hyperglyceamia is pre-diabetic state. Aim of the study: The aim of this study was to compare the outcome of hyperglyceami...
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HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors
Qing Wu,
Yulei Xie,
Yinxu Wang,
Xin Chen
Issue:
Volume 10, Issue 4, August 2022
Pages:
125-130
Received:
16 February 2022
Accepted:
8 July 2022
Published:
5 August 2022
DOI:
10.11648/j.ajbls.20221004.15
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Abstract: Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O2 content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.
Abstract: Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the r...
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