HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors

Qing Wu; Yulei Xie; Yinxu Wang; Xin Chen

doi:doi:10.11648/j.ajbls.20221004.15

| Peer-Reviewed

HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors

Qing Wu, Yulei Xie, Yinxu Wang, Xin Chen

Published in American Journal of Biomedical and Life Sciences (Volume 10, Issue 4)

Received: 16 February 2022 Accepted: 8 July 2022 Published: 5 August 2022

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O₂ content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.

Published in	American Journal of Biomedical and Life Sciences (Volume 10, Issue 4)
DOI	10.11648/j.ajbls.20221004.15
Page(s)	125-130
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hypoxia Inducible Factor-1, Cell Signaling Pathway, Gastrointestinal Tumors

References

[1]	Ke Q and Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol, 2006, 70 (5): 1469-1480.
[2]	Semenza GL and Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol, 1992, 12 (12): 5447-5454.
[3]	Befani C and Liakos P. The role of hypoxia-inducible factor-2 alpha in angiogenesis. J Cell Physiol, 2018, 233 (12): 9087-9098.
[4]	Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O₂ tension. Proc Natl Acad Sci U S A, 1995, 92 (12): 5510-5514.
[5]	Loboda A, Jozkowicz A and Dulak J. HIF-1 and HIF-2 transcription factors--similar but not identical. Mol Cells, 2010, 29 (5): 435-442.
[6]	Semenza GL. A compendium of proteins that interact with HIF-1α. Exp Cell Res, 2017, 356 (2): 128-135.
[7]	Bruick RK and McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science, 2001, 294 (5545): 1337-1340.
[8]	Iwai K, Yamanaka K, Kamura T, et al. Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A, 1999, 96 (22): 12436-12441.
[9]	Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell, 2001, 107 (1): 43-54.
[10]	Block KM, Wang H, Szabó LZ, et al. Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine. J Am Chem Soc, 2009, 131 (50): 18078-18088.
[11]	Masoud GN and Li W. HIF-1α pathway: role, regulation and intervention for cancer therapy. Acta Pharm Sin B, 2015, 5 (5): 378-389.
[12]	Hirai K, Furusho H, Hirota K, et al. Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss. Int J Oral Sci, 2018, 10 (2): 12.
[13]	McGarry T, Biniecka M, Veale DJ, et al. Hypoxia, oxidative stress and inflammation. Free Radic Biol Med, 2018, 125: 15-24.
[14]	Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer, 2003, 3 (10): 721-732.
[15]	Jeong JW, Bae MK, Ahn MY, et al. Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell, 2002, 111 (5): 709-720.
[16]	Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature, 1999, 399 (6733): 271-275.
[17]	Dann CE, 3rd, Bruick RK and Deisenhofer J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci U S A, 2002, 99 (24): 15351-15356.
[18]	Lando D, Peet DJ, Gorman JJ, et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev, 2002, 16 (12): 1466-1471.
[19]	McNeill LA, Hewitson KS, Claridge TD, et al. Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. Biochem J, 2002, 367 (Pt 3): 571-575.
[20]	Kaelin WG. Proline hydroxylation and gene expression. Annu Rev Biochem, 2005, 74: 115-128.
[21]	Berra E, Benizri E, Ginouvès A, et al. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. Embo j, 2003, 22 (16): 4082-4090.
[22]	Lee MC, Huang HJ, Chang TH, et al. Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep, 2016, 6: 29311.
[23]	Buckley DL, Van Molle I, Gareiss PC, et al. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction. J Am Chem Soc, 2012, 134 (10): 4465-4468.
[24]	Chen J, Bai M, Ning C, et al. Gankyrin facilitates follicle-stimulating hormone-driven ovarian cancer cell proliferation through the PI3K/AKT/HIF-1α/cyclin D1 pathway. Oncogene, 2016, 35 (19): 2506-2517.
[25]	Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res, 2000, 60 (6): 1541-1545.
[26]	Erler JT, Bennewith KL, Cox TR, et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell, 2009, 15 (1): 35-44.
[27]	Yang XM, Wang YS, Zhang J, et al. Role of PI3K/Akt and MEK/ERK in mediating hypoxia-induced expression of HIF-1alpha and VEGF in laser-induced rat choroidal neovascularization. Invest Ophthalmol Vis Sci, 2009, 50 (4): 1873-1879.
[28]	Karar J, Cerniglia GJ, Lindsten T, et al. Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia. Cancer Biol Ther, 2012, 13 (11): 1102-1111.
[29]	Li L, Qu Y, Mao M, et al. The involvement of phosphoinositid 3-kinase/Akt pathway in the activation of hypoxia-inducible factor-1alpha in the developing rat brain after hypoxia-ischemia. Brain Res, 2008, 1197: 152-158.
[30]	Lei Q, Tan J, Yi S, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett, 2018, 23: 14.
[31]	Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol, 2002, 64 (5-6): 993-998.
[32]	Shi YH, Wang YX, Bingle L, et al. In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D breast cancer cell line under normoxic conditions: involvement of PI-3K/Akt and MEK1/ERK pathways. J Pathol, 2005, 205 (4): 530-536.
[33]	Bae MK, Ahn MY, Jeong JW, et al. Jab1 interacts directly with HIF-1alpha and regulates its stability. J Biol Chem, 2002, 277 (1): 9-12.
[34]	Ravi R, Mookerjee B, Bhujwalla ZM, et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev, 2000, 14 (1): 34-44.
[35]	Liu YV and Semenza GL. RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. Cell Cycle, 2007, 6 (6): 656-659.
[36]	Minet E, Michel G, Remacle J, et al. Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review). Int J Mol Med, 2000, 5 (3): 253-259.
[37]	Adhikary S and Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol, 2005, 6 (8): 635-645.
[38]	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68 (6): 394-424.
[39]	Shao JB, Li Z, Zhang N, et al. Hypoxia-inducible factor 1α in combination with vascular endothelial growth factor could predict the prognosis of postoperative patients with oesophageal squamous cell cancer. Pol J Pathol, 2019, 70 (2): 84-90.
[40]	Jászai J and Schmidt MHH. Trends and Challenges in Tumor Anti-Angiogenic Therapies. Cells, 2019, 8 (9).
[41]	Zeng L, Zhou HY, Tang NN, et al. Wortmannin influences hypoxia-inducible factor-1 alpha expression and glycolysis in esophageal carcinoma cells. World J Gastroenterol, 2016, 22 (20): 4868-4880.
[42]	Shao C, Ji C, Wang X, et al. Expression and significance of GRHL2 in esophageal cancer. Onco Targets Ther, 2017, 10: 2025-2031.
[43]	Katsuta M, Miyashita M, Makino H, et al. Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer. Exp Mol Pathol, 2005, 78 (2): 123-130.
[44]	Zhu Y, Tan J, Xie H, et al. HIF-1α regulates EMT via the Snail and β-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis. J Cell Mol Med, 2016, 20 (4): 688-697.
[45]	Zong L, Abe M, Seto Y, et al. The challenge of screening for early gastric cancer in China. Lancet, 2016, 388 (10060): 2606.
[46]	Zhang J, Xu J, Dong Y, et al. Down-regulation of HIF-1α inhibits the proliferation, migration, and invasion of gastric cancer by inhibiting PI3K/AKT pathway and VEGF expression. Biosci Rep, 2018, 38 (6).
[47]	Huang T, Liu HW, Chen JQ, et al. The long noncoding RNA PVT1 functions as a competing endogenous RNA by sponging miR-186 in gastric cancer. Biomed Pharmacother, 2017, 88: 302-308.
[48]	Hong L, Wang J, Wang H, et al. Linc-pint overexpression inhibits the growth of gastric tumors by downregulating HIF-1α. Mol Med Rep, 2019, 20 (3): 2875-2881.
[49]	Ge X, Liu X, Lin F, et al. MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer. Oncotarget, 2016, 7 (17): 24466-24482.
[50]	Liu L, Zhao X, Zou H, et al. Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent Transcriptional Activation of the Long Non-coding RNA GAPLINC. Front Physiol, 2016, 7: 420.
[51]	Romano E, Vllahu M, Bizzarro V, et al. TFF1 Promotes EMT-Like Changes through an Auto-Induction Mechanism. Int J Mol Sci, 2018, 19 (7).
[52]	Liu N, Wang Y, Zhou Y, et al. Krüppel-like factor 8 involved in hypoxia promotes the invasion and metastasis of gastric cancer via epithelial to mesenchymal transition. Oncol Rep, 2014, 32 (6): 2397-2404.
[53]	Yang SW, Zhang ZG, Hao YX, et al. HIF-1α induces the epithelial-mesenchymal transition in gastric cancer stem cells through the Snail pathway. Oncotarget, 2017, 8 (6): 9535-9545.
[54]	Kannan A, Krishnan A, Ali M, et al. Caveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic condition. Eur J Cancer, 2014, 50 (1): 204-215.
[55]	Xiong XX, Qiu XY, Hu DX, et al. Advances in Hypoxia-Mediated Mechanisms in Hepatocellular Carcinoma. Mol Pharmacol, 2017, 92 (3): 246-255.
[56]	Wu FQ, Fang T, Yu LX, et al. ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α. J Hepatol, 2016, 65 (2): 314-324.
[57]	Liu X, Chen S, Tu J, et al. HSP90 inhibits apoptosis and promotes growth by regulating HIF-1α abundance in hepatocellular carcinoma. Int J Mol Med, 2016, 37 (3): 825-835.
[58]	Wang Y, Ma J, Shen H, et al. Reactive oxygen species promote ovarian cancer progression via the HIF-1α/LOX/E-cadherin pathway. Oncol Rep, 2014, 32 (5): 2150-2158.
[59]	Wang B, Ding YM, Fan P, et al. Expression and significance of MMP2 and HIF-1α in hepatocellular carcinoma. Oncol Lett, 2014, 8 (2): 539-546.
[60]	Okazaki I and Inagaki Y. Novel strategies for hepatocellular carcinoma based on MMPs science. Anticancer Agents Med Chem, 2012, 12 (7): 753-763.

Cite This Article

Plain Text BibTeX RIS

APA Style

Qing Wu, Yulei Xie, Yinxu Wang, Xin Chen. (2022). HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. American Journal of Biomedical and Life Sciences, 10(4), 125-130. https://doi.org/10.11648/j.ajbls.20221004.15

Copy | Download

ACS Style

Qing Wu; Yulei Xie; Yinxu Wang; Xin Chen. HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. Am. J. Biomed. Life Sci. 2022, 10(4), 125-130. doi: 10.11648/j.ajbls.20221004.15

Copy | Download

AMA Style

Qing Wu, Yulei Xie, Yinxu Wang, Xin Chen. HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. Am J Biomed Life Sci. 2022;10(4):125-130. doi: 10.11648/j.ajbls.20221004.15

Copy | Download

@article{10.11648/j.ajbls.20221004.15,
  author = {Qing Wu and Yulei Xie and Yinxu Wang and Xin Chen},
  title = {HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {10},
  number = {4},
  pages = {125-130},
  doi = {10.11648/j.ajbls.20221004.15},
  url = {https://doi.org/10.11648/j.ajbls.20221004.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221004.15},
  abstract = {Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O2 content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors
AU  - Qing Wu
AU  - Yulei Xie
AU  - Yinxu Wang
AU  - Xin Chen
Y1  - 2022/08/05
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbls.20221004.15
DO  - 10.11648/j.ajbls.20221004.15
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 125
EP  - 130
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20221004.15
AB  - Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O2 content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.
VL  - 10
IS  - 4
ER  -

Copy | Download

Author Information

Qing Wu

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
Yulei Xie

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
Yinxu Wang

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
Xin Chen

Department of Rehabilitation Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Qing Wu, Yulei Xie, Yinxu Wang, Xin Chen. (2022). HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. American Journal of Biomedical and Life Sciences, 10(4), 125-130. https://doi.org/10.11648/j.ajbls.20221004.15

Copy | Download

ACS Style

Qing Wu; Yulei Xie; Yinxu Wang; Xin Chen. HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. Am. J. Biomed. Life Sci. 2022, 10(4), 125-130. doi: 10.11648/j.ajbls.20221004.15

Copy | Download

AMA Style

Qing Wu, Yulei Xie, Yinxu Wang, Xin Chen. HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors. Am J Biomed Life Sci. 2022;10(4):125-130. doi: 10.11648/j.ajbls.20221004.15

Copy | Download

@article{10.11648/j.ajbls.20221004.15,
  author = {Qing Wu and Yulei Xie and Yinxu Wang and Xin Chen},
  title = {HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {10},
  number = {4},
  pages = {125-130},
  doi = {10.11648/j.ajbls.20221004.15},
  url = {https://doi.org/10.11648/j.ajbls.20221004.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20221004.15},
  abstract = {Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O2 content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - HIF-1α Related Signaling Pathway and Its Role in Common Gastrointestinal Tumors
AU  - Qing Wu
AU  - Yulei Xie
AU  - Yinxu Wang
AU  - Xin Chen
Y1  - 2022/08/05
PY  - 2022
N1  - https://doi.org/10.11648/j.ajbls.20221004.15
DO  - 10.11648/j.ajbls.20221004.15
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 125
EP  - 130
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20221004.15
AB  - Esophageal cancer, gastric cancer and liver cancer are common digestive tract tumors. at present, radical surgery, radiotherapy and chemotherapy and traditional chinese medicine are the main clinical treatments for digestive tract tumors, but the morbidity and mortality of patients are still high. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors. Therefore, it is very important to strengthen the research on the pathogenesis of digestive tract tumors in order to find the biomarkers and therapeutic targets for the early diagnosis of digestive tract tumors. Hypoxia-inducible factor-1 (Hypoxia-inducible factor-1, HIF-1), as an important regulator in hypoxia environment, is a heterodimer composed of subunits α and β. Its role is mainly determined by HIF-1α, by the fine regulation of O2 content in the microenvironment, and participates in the regulation of a variety of tumor signal pathways. There is a strong correlation between high expression of HIF-1α and tumor metastasis, angiogenesis, poor prognosis and drug resistance treatment. This article reviews the research progress on the structure, function, expression regulation, action mechanism and role of HIF-1α in common digestive tract tumors, in order to provide theoretical basis for clinical treatment of digestive tract tumors.
VL  - 10
IS  - 4
ER  -

Copy | Download