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Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds
Ataa Said,
Elsayed Ali Abuotabl,
Gehan Fawzy Abdel Raoof,
Khaled Younes Mohamed
Issue:
Volume 4, Issue 2, June 2018
Pages:
30-35
Received:
8 March 2018
Accepted:
24 March 2018
Published:
12 April 2018
Abstract: The aim of this study is to evaluate antihyperglycaemi cand antihyperlipidemic activities of Pleiogynium timorense (DC.) Leenh (Anacardiaceae) seeds as well as to isolate and identify the bioactive compounds. Antihyperglycaemic effect was evaluated by measuring the effect of two dose levels (150 and 300 mg/kg) of 70% methanol extract of Pleiogynium timorense seeds on the blood glucose level. In addition, the effect of the plant extract on the lipid profile was determined by measuring serum total lipids (TL), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Furthermore, the bioactive compounds were isolated and identified by chromatographic and spectrometric methods. The results showed that the methanolic extract of the seeds significantly reduced the levels of blood glucose, (TL), (TC), (TG) and (LDL-C) but no significant effect on (HDL-C) by comparing with control group. Furthermore, four phenolic compound were isolated which were identified as; catechin, gallic acid, paramethoxybenzaldehyde and pyrogallol which were isolated for the first time from the seeds of the plant. In addition sulphur -containing compound (sulpholane) was isolated for the first time from the plant and from the family. To our knowledge, this is the first study about antihyperglycaemic and antihyperlipidemic activities of the seeds of Pleiogynium timorense and its bioactive compounds. So, the methanolic extract of the seeds of Pleiogynium timorense could be a step towards the development of new antihyperglycaemic and antihyperlipidemic drugs.
Abstract: The aim of this study is to evaluate antihyperglycaemi cand antihyperlipidemic activities of Pleiogynium timorense (DC.) Leenh (Anacardiaceae) seeds as well as to isolate and identify the bioactive compounds. Antihyperglycaemic effect was evaluated by measuring the effect of two dose levels (150 and 300 mg/kg) of 70% methanol extract of Pleiogynium...
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Multi-Scenarios Dynamic Matching Algorithm for Hierarchical Treatment System
Min Zhou,
Lindu Zhao,
Shujuan Qu,
Kathryn Sarah Campy
Issue:
Volume 4, Issue 2, June 2018
Pages:
36-47
Received:
7 March 2018
Accepted:
27 March 2018
Published:
18 April 2018
Abstract: In China, 10% of medical resource are general hospital which treat 86% patients. This will lead the health resources in these hospitals become insufficient and exhaust, even if the resources in other hospitals idle. Previous studies have indicated that the scattering resource systems will result in significant imbalances if it lacks stable and effective match. To deal with Two-Sided Matching (TSM) problem in hierarchical medical system, a matching decision-making approach based on multiple scenarios was proposed. The algorithm was designed to adapt four kinds of scenarios, it analyzed multi-context matching satisfaction degree of these cooperation situations in different forms of environment respectively and specifically．By comparing the examples, the multi - scenario dynamic matching method is superior to the random matching algorithm and the “F-Y” algorithm (improved G - S algorithm), and it is effective to obtain the stable and feasible solution. This paper showed a multi-scenarios dynamic matching algorithm for hierarchical treatment system by modifying comprehensive satisfaction integration function and differential adjustment function. This paper concentrated on the stability and total satisfaction goals of system matching. This method serves as a decision-making reference for the bilateral matching encountered in the problem of “hierarchical treatment system” around the world.
Abstract: In China, 10% of medical resource are general hospital which treat 86% patients. This will lead the health resources in these hospitals become insufficient and exhaust, even if the resources in other hospitals idle. Previous studies have indicated that the scattering resource systems will result in significant imbalances if it lacks stable and effe...
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A Review on Health and Nutrition Status in Bangladesh: Issues and Challenges
Md. Monirul Islam,
Md. Ibrahim,
Israt Jahan Ira,
Md. Abu Torab,
Md. Zakir Hossen,
Zobayer Hossain
Issue:
Volume 4, Issue 2, June 2018
Pages:
48-53
Received:
8 March 2018
Accepted:
26 March 2018
Published:
4 May 2018
Abstract: Health is a right, not privilege. It needs to be delivered with equity. National economic and social developments depend a lot on the state of health services. Bangladesh territory is one of the largest deltas of the world. It is a low lying country and has borders with India on three sides. The country is covered with a network of rivers and canals. Bangladesh mostly comprises floodplain areas, with scattered hills at the eastern and the northern parts. Bangladesh is recognized as the worst victim of global climate change effects. The country manifests all the direct and indirect effects of climate change, such as global warming and sea level rise. As a result, human health has to bear enormous costs. A large number of Bangladeshis, particularly in the rural areas have little access to healthcare facilities. This study was aimed to find out the major public health issues and challenges in Bangladesh. Bangladesh has one of the worst burdens of childhood malnutrition in the world. Communicable diseases are a major cause of death and disability in Bangladesh. Pneumonia and other infections are major causes of death among young children. Unsafe food remains a major threat to public health each year. Different non-communicable diseases — chronic diseases, cancer, diabetes, cardiovascular diseases, and chronic respiratory diseases — is increasing in Bangladesh as the population becomes more urbanized. The disease burden Bangladesh is further exacerbated by unsanitary living conditions that underscore the poor economic conditions of both urban and rural home dwellers. There are still several issues that Bangladesh health care system is yet to tackle and such issues are preventing the implementation of solutions to the public health issues in Bangladesh.
Abstract: Health is a right, not privilege. It needs to be delivered with equity. National economic and social developments depend a lot on the state of health services. Bangladesh territory is one of the largest deltas of the world. It is a low lying country and has borders with India on three sides. The country is covered with a network of rivers and canal...
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Dependence of Premature Births from Periodontal Status of Pregnant Women
Sonila Robo,
Ilma Robo,
Eduart Kapaj,
Saimir Heta
Issue:
Volume 4, Issue 2, June 2018
Pages:
54-57
Received:
10 March 2018
Accepted:
28 March 2018
Published:
9 May 2018
Abstract: Background: Early birth is 37 weeks or less, pregnancy maturity! Clinically active presence, or positive culture of vaginal secretions, means excessive production of cytokines and prostaglandins also encountered in amniotic fluid. Bacterial vaginosis appears with their clinical outbreak in a combination of bacteria. Some of these bacteria are basic members in the creation of bacterial plaque. Objective: The purpose of this study is to find the link between the presence of specific bacteria in the mouth, bacterial vaginosis as one of the causes of premature birth, and the latter. Methods: The study was applied to 30 pregnant women in the burden pathology ward at Fier maternity, divided into two groups. The first group consisting of 20 women in the 2-month period, August-September 2011. The number of women in the ward was 10 days maximum! All women were treated with cortisone and serum IV, magnesium sulphate, antibiotic prophylaxis! Results: 55% of women were under the age of 25 and 45% of women were over the age of 25. The age effect is mentioned for classifying the diseases that causes Actinomyces. Under the age of 25, a teenager and a 25-year-old are chronically ill. The final index was G2! All females were positive for the presence of salicylic acid in saliva and vaginal secretions. Conclusions: Premature birth is a complex process with some gynecological reasons, but in high percentage of cases there is coverage with the presence of infection by Actinomyces Actinomycetemcomitans in the oral cavity, which depending on the age causes two different types of periodontitis with special characteristics.
Abstract: Background: Early birth is 37 weeks or less, pregnancy maturity! Clinically active presence, or positive culture of vaginal secretions, means excessive production of cytokines and prostaglandins also encountered in amniotic fluid. Bacterial vaginosis appears with their clinical outbreak in a combination of bacteria. Some of these bacteria are basic...
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Phytochemical and Antimicrobial Studies of Colloidal Silver Nanoparticles Mediated by Laportea aestuans Extract
Issue:
Volume 4, Issue 2, June 2018
Pages:
58-65
Received:
26 May 2018
Accepted:
19 June 2018
Published:
24 July 2018
Abstract: This present report describes studies on the phytochemical screening and antimicrobial activity of colloidal silver nanoparticles (AgNPs) mediated by Laportea aestuans leaf extract in aqueous solution. Herein, AgNPs were facilely synthesized using the fresh leaf extract of Laportea aestuans in water. UV-Vis absorption spectrum of as-prepared AgNPs shows surface plasmon resonance (SPR) peak at ≈ 453 nm, suggesting successful formation of AgNPs. The X-ray diffraction pattern of the AgNPs were consistent with the Bragg’s reflections of AgNPs. Transmission electron microscope revealed that the prepared AgNPs are monodisperse, slightly non-aggregated and quasi-spherical in shapes. Phytochemical screenings of the leaves of L. aestuans shows presence of important bio-organic molecules that are responsible for the reduction, growth and stabilization of as-prepared AgNPs in aqueous solution. Bactericidal effects of the as-prepared biosynthesized AgNPs were carried out against pathogenic Gram-negative (Pseudomonas aeruginosa and Salmonella typhi) and Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacteria. Biosynthesized AgNPs showed enhanced antimicrobial activity against S. aureus (gram positive) and S. typhi (gram negative), compared to B. subtilis (gram positive) and P. aeruginosa (gram negative) at the tested concentrations. Impressive antimicrobial activity of L-Ag against the tested pathogens could be attributed to the synergistic effects of the biomolecules in the Laportea aestuans plants and silver nanostructures.
Abstract: This present report describes studies on the phytochemical screening and antimicrobial activity of colloidal silver nanoparticles (AgNPs) mediated by Laportea aestuans leaf extract in aqueous solution. Herein, AgNPs were facilely synthesized using the fresh leaf extract of Laportea aestuans in water. UV-Vis absorption spectrum of as-prepared AgNPs ...
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