International Journal of Biomedical Science and Engineering

Archive

Volume 5, Issue 6, December 2017

  • Bring CLARITY to Temporal Lobe Epilepsy: 3D Visualization of p-Tau(Ser262) and 14-3-3 Zeta

    Qingqin Wu, Honghong Song, Juan Feng, Yang Xia, Dezhong Yao

    Issue: Volume 5, Issue 6, December 2017
    Pages: 63-67
    Received: 5 December 2017
    Published: 6 December 2017
    DOI: 10.11648/j.ijbse.20170506.11
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    Abstract: CLARITY is one new technology which allows the brain tissue become transparent. It has successfully been combined with immunofluorescence staining to achieve the 3D visualization of some molecules or neuronal cells in some disease brains. The temporal lobe epilepsy (TLE) is one neuronal disease which is characterized by the sprouting of the massy f... Show More
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  • Application of CLARITY to Investigate the 3D Architecture of 14-3-3 Zeta Protein in AD

    Honghong Song, Juan Feng, Jian Li, Yang Xia, Dezhong Yao

    Issue: Volume 5, Issue 6, December 2017
    Pages: 68-71
    Received: 5 December 2017
    Published: 6 December 2017
    DOI: 10.11648/j.ijbse.20170506.12
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    Abstract: CLARITY (Clear Lipid–exchanged Acrylamide–hybridized Rigid Imaging/ Immunostaining/ in situ–hybridization–compatible Tissue hydrogel) is a powerful, innovative, whole brain-clearing technology, and it has been successfully combined with the immunofluorescence staining to achieve the 3D visualization of some proteins or cells in mm-thick brain tissu... Show More
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