Cancer Research Journal

Volume 13, Issue 2, June 2025

  • Research Article

    Telomere Elongation and Mismatch Repair Deficiency Distinguish MSI Colorectal Cancer Cell Lines

    Rajasekhar Moka*, Shreya Upadhya

    Issue: Volume 13, Issue 2, June 2025
    Pages: 23-29
    Received: 17 April 2025
    Accepted: 29 April 2025
    Published: 29 May 2025
    DOI: 10.11648/j.crj.20251302.11
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    Abstract: Microsatellite instability (MSI) is a hallmark of mismatch repair (MMR) deficiency and characterizes a distinct subset of colorectal cancers (CRC). In parallel, telomere length dynamics have emerged as important contributors to genomic stability and tumorigenesis. However, the relationship between MSI status, MMR protein expression, and telomere ma... Show More