World Journal of Food Science and Technology

Submit a Manuscript

Publishing with us to make your research visible to the widest possible audience.

Propose a Special Issue

Building a community of authors and readers to discuss the latest research and develop new ideas.

Research Article |

Design of an Effective Nutraceutical (“SR45”) for Low Mood Management

Introduction: Herbal products play a crucial role in traditional Chinese medicine, offering a holistic approach to disease treatment. Botanicals and their active components have shown promise in addressing depression-like symptoms. Unlike antidepressant medications, botanicals offer a natural alternative with milder side effects. This study explores the potential of botanical compounds as antidepressants. Natural Products for Low Mood Management: Crocus Sativus (Saffron): Derived from the Crocus sativus flower, saffron has demonstrated effectiveness in relieving symptoms of mild to moderate anxiety, comparable to standard antidepressants. Cost-effective petal extracts have proven to be viable alternatives. Rhodiola Rosea (Rhodiola): Used traditionally to enhance physical and mental performance, Rhodiola extracts have shown promise in reducing anxiety and depression symptoms. Development of SR45: Bioactive compounds hold significant potential for enhancing nutraceutical functionality. Encapsulation systems have emerged as a transformative technology for improving bioactive stability and bioavailability. SR45, developed with Rhodiola on a lipid basis and advanced encapsulation techniques, aims to enhance the bioavailability of key bioactive ingredients. Preliminary Clinical Results Obtained with SR45: A randomized clinical trial evaluated SR45's efficacy and safety in individuals with low mood. Participants taking SR45 experienced a statistically significant reduction in depression and anxiety symptoms compared to the placebo group. Both groups showed improvement, highlighting the placebo effect, essential for robust study execution. No adverse events related to SR45 were observed, indicating its safety. Conclusions: Daily consumption of SR45 capsules over 8 weeks led to a reduction in depression in individuals with mild symptoms. SR45 also demonstrated effectiveness in reducing anxiety in individuals with mild to moderate symptoms. SR45 was found to be safe for consumption at the specified doses over the 8-week period. This preliminary study suggests that SR45 holds promise as a natural supplement for managing low mood. Further research is warranted to validate these findings and explore the potential of SR45 in a larger population.

Crocus Sativus, Rhodiola Rosea, Low Mood

APA Style

Moran, J. (2023). Design of an Effective Nutraceutical (“SR45”) for Low Mood Management. World Journal of Food Science and Technology, 7(4), 77-80. https://doi.org/10.11648/j.wjfst.20230704.11

ACS Style

Moran, J. Design of an Effective Nutraceutical (“SR45”) for Low Mood Management. World J. Food Sci. Technol. 2023, 7(4), 77-80. doi: 10.11648/j.wjfst.20230704.11

AMA Style

Moran J. Design of an Effective Nutraceutical (“SR45”) for Low Mood Management. World J Food Sci Technol. 2023;7(4):77-80. doi: 10.11648/j.wjfst.20230704.11

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Wang, Jigang et al (2018). What has traditional Chinese medicine delivered for modern medicine?. Expert reviews in molecular medicine vol. 20 e4. 11 May. doi: 10.1017/erm.2018.3.
2. Sarris, Jerome et al (2011). Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology vol. 21, 12: 841-60. doi: 10.1016/j.euroneuro.2011.04.002.
3. Sarris, Jerome (2018). Herbal medicines in the treatment of psychiatric disorders: 10-year updated review. Phytotherapy research: PTR vol. 32, 7: 1147-1162. doi: 10.1002/ptr.6055.
4. Pitsikas, Nikolaos (2016). Constituents of Saffron (Crocus sativus L.) as Potential Candidates for the Treatment of Anxiety Disorders and Schizophrenia. Molecules (Basel, Switzerland) vol. 21, 3 303. 2 Mar., doi: 10.3390/molecules21030303.
5. Cropley, Mark et al (2015). The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytotherapy research: PTR vol. 29, 12: 1934-9. doi: 10.1002/ptr.5486.
6. Sachdeva, Vedant et al (2020). Current Prospects of Nutraceuticals: A Review. Current pharmaceutical biotechnology vol. 21, 10: 884-896. doi: 10.2174/1389201021666200130113441.
7. Aronson, Jeffrey K (2017). Defining 'nutraceuticals': neither nutritious nor pharmaceutical. British journal of clinical pharmacology vol. 83, 1: 8-19. doi: 10.1111/bcp.12935.
8. Alqahtani, Mohammed S et al (2021). Advances in Oral Drug Delivery. Frontiers in pharmacology vol. 12 618411. 19 Feb, doi: 10.3389/fphar.2021.618411.
9. Sangiovanni, Enrico et al (2017). Botanicals as Modulators of Neuroplasticity: Focus on BDNF. Neural plasticity vol. 2017: 5965371. doi: 10.1155/2017/5965371.
10. Amsterdam, Jay D, and Alexander G Panossian (2016). Rhodiola rosea L. as a putative botanical antidepressant. Phytomedicine: international journal of phytotherapy and phytopharmacology vol. 23, 7: 770-83. doi: 10.1016/j.phymed.2016.02.009.
11. Granato, Daniel et al (2020). Functional Foods: Product Development, Technological Trends, Efficacy Testing, and Safety. Annual review of food science and technology vol. 11: 93-118. doi: 10.1146/annurev-food-032519-051708.
12. Boland, Mike (2016). Human digestion--a processing perspective. Journal of the science of food and agriculture vol. 96, 7: 2275-83. doi: 10.1002/jsfa.7601.
13. Muszyńska, Bożena et al (2015). Natural products of relevance in the prevention and supportive treatment of depression. Psychiatria polska vol. 49, 3: 435-53. doi: 10.12740/PP/29367.
14. Dima, Cristian et al (2023). Oral bioavailability of bioactive compounds; modulating factors, in vitro analysis methods, and enhancing strategies. Critical reviews in food science and nutrition, 1-39. 25 Apr., doi: 10.1080/10408398.2023.2199861.
15. Sarris, Jerome (2007). Herbal medicines in the treatment of psychiatric disorders: a systematic review. Phytotherapy research: PTR vol. 21, 8: 703-16. doi: 10.1002/ptr.2187.
16. Zhu, Hongkang et al (2022). Pharmaceutical Potential of High-Altitude Plants for Fatigue-Related Disorders: A Review. Plants (Basel, Switzerland) vol. 11, 15 2004. doi: 10.3390/plants11152004.
17. Grosso, Clara et al (2023). From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders. Antioxidants (Basel, Switzerland) vol. 12, 8 1603. doi: 10.3390/antiox12081603.
18. Bangratz, Marie et al (2018). A preliminary assessment of a combination of rhodiola and saffron in the management of mild-moderate depression. Neuropsychiatric disease and treatment vol. 14 1821-1829. doi: 10.2147/NDT.S169575.
19. Williams, J B (1988). A structured interview guide for the Hamilton Depression Rating Scale. Archives of general psychiatry vol. 45, 8: 742-7. doi: 10.1001/archpsyc.1988.01800320058007.
20. Bruss, G S et al (1994). Hamilton Anxiety Rating Scale Interview guide: joint interview and test-retest methods for interrater reliability. Psychiatry research vol. 53, 2: 191-202. doi: 10.1016/0165-1781(94)90110-4. v