A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women

Yakubu Emmanuel Nyam; Ajen Stephen Anzaku; Madziga Isa Gamece; Daru Patrick Haruna

doi:doi:10.11648/j.sr.20140206.11

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A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women

Yakubu Emmanuel Nyam, Ajen Stephen Anzaku, Madziga Isa Gamece, Daru Patrick Haruna

Published in Science Research (Volume 2, Issue 6)

Received: 6 November 2014 Accepted: 17 November 2014 Published: 24 November 2014

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Abstract

Background: Pre-eclampsia is a hypertensive disorder in pregnancy, that has adverse maternal and perinatal outcomes. Abnormal serum lipid levels have been implicated in the pathogenesis of pre-eclampsia, this can give rise to increased oxidative stress and then subsequently, endothelial dysfunction. Methods: This study was a comparative cross-sectional study that involved fifty pregnant women that had pre-eclampsia and another fifty healthy pregnant women. Cases and controls were matched for Age in years, Parity, Gestational age in weeks and Body mass index in Kg/M2. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) using enzymatic colorimetric method aided by Cobass C111 Autoanalyser machine. The Data was analyzed using Epi-info version 3.5.4, CDC, Atlanta, USA and P <0.05 was considered significant. Results: Mean age of the case and control groups were 28.86 + 4.50 Years and 29.9 + 4.95 Years respectively (P = 0.59). Statistical analysis revealed no significant difference in terms of total Cholesterol (P = 0.98) and low density lipoprotein (P = 0.92). However, mean triglycerides (1.95 + 0.89 mmol/L versus 1.02 + 0.51 mmoI/L) was significantly higher in women with pre-eclampsia compared to the control (P= 0.0004) and a significant reduction in high density lipoprotein (0.79± 0.30 mmol/L versus 1.74 + 0.45 mmol/L) in the case group (P = 0.0005). Conclusion: In this study, Pre-eclampsia is associated with elevated serum triglycerides and reduced high density lipoprotein. These findings may serve as screening markers for preeclampsia.

Published in	Science Research (Volume 2, Issue 6)
DOI	10.11648/j.sr.20140206.11
Page(s)	150-154
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Pre-Eclampsia, Serum Lipids, Total Cholesterol, Triglycerides, High Density Lipoprotein, Low Density Lipoprotein

References

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[3]	Abudu O.O, Afolabi B.B. Pregnancy induced hypertension, Pre-eclampsia and Chronic hypertension. In: Akin Agboola (Ed), Textbook of Obstetrics and Gynaecology for Medical Students. 2nd edition; Heinemann Educational Books. 2006:350-51.
[4]	Vanderjagt DJ, El-Nafaty AU, Melah GS et.al High density lipoprotein and homocysteine levels correlate inversely in preeclamptics women in Northern Nigeria. Acta Obstet Gynaecol Scand J 2004; 83: 536-42.
[5]	NAF Islam, MAR Chodwury, GM Kibria et.al Study of serum lipid profile in pre-eclampsia and Eclampsia. Faridpur Med coll J 2010;5:56-9.
[6]	Siddiqui IA. Maternal seum lipids in women with Preeclampsia. Ann Med Health Sci Res 2014;4:638-41.
[7]	Young BC, Levine RJ, Karumanchi SA. Pathogenesis of Preeclampsia. Annu Rev Pathol 2010,5:173-92.
[8]	Enquobahrie DA, Williams MA, Buttler CL, et.al Maternal plasma lipid concentration in early pregnancy and risk of preeclampsia. Am J Hypertens 2008; 17: 74-81.
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[10]	Brown MA, Lindheimer MD, de Sweit M. The classification and diagnosis of the hypertensive disorder of pregnancy. Statement from the international society for the study of hypertension in pregnancy (ISSHP) Hypertens Pregnancy 2001; 20:9-14.
[11]	Zinat B, Iffat A, Shah ABS. Association between lipid profile and Preeclampsia. Ibrahim card Med J 2011; 1:41-44.
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[17]	Abubakar A. Mabrouk M. Girei AB et.al Lipid profiles and Platelet counts of pre-eclamptic women in selected rural areas of Nigeria. Web Med Central Physiology.2011:2(8) WMCOO2121.
[18]	Ray JG, Diamond P, Singh G, Bell CM. Brief overview of maternal triglycerides as a risk factor for pre-eclampsia. BJOG 2006; 113:379-86.
[19]	Kalar MU, Kalar N, Mansoor F, Malik AR, Lessley T, Kreimer S et al. Preeclampsia and lipid levels – a case control study. International Journal of Collaborative research in internal Medicine and Public Health 2012; 4: 1738 – 45.
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APA Style

Yakubu Emmanuel Nyam, Ajen Stephen Anzaku, Madziga Isa Gamece, Daru Patrick Haruna. (2014). A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women. Science Research, 2(6), 150-154. https://doi.org/10.11648/j.sr.20140206.11

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ACS Style

Yakubu Emmanuel Nyam; Ajen Stephen Anzaku; Madziga Isa Gamece; Daru Patrick Haruna. A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women. Sci. Res. 2014, 2(6), 150-154. doi: 10.11648/j.sr.20140206.11

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AMA Style

Yakubu Emmanuel Nyam, Ajen Stephen Anzaku, Madziga Isa Gamece, Daru Patrick Haruna. A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women. Sci Res. 2014;2(6):150-154. doi: 10.11648/j.sr.20140206.11

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@article{10.11648/j.sr.20140206.11,
  author = {Yakubu Emmanuel Nyam and Ajen Stephen Anzaku and Madziga Isa Gamece and Daru Patrick Haruna},
  title = {A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women},
  journal = {Science Research},
  volume = {2},
  number = {6},
  pages = {150-154},
  doi = {10.11648/j.sr.20140206.11},
  url = {https://doi.org/10.11648/j.sr.20140206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sr.20140206.11},
  abstract = {Background: Pre-eclampsia is a hypertensive disorder in pregnancy, that has adverse maternal and perinatal outcomes. Abnormal serum lipid levels have been implicated in the pathogenesis of pre-eclampsia, this can give rise to increased oxidative stress and then subsequently, endothelial dysfunction.  Methods: This study was a comparative cross-sectional study that involved fifty pregnant women that had pre-eclampsia and another fifty healthy pregnant women. Cases and controls were matched for Age in years, Parity, Gestational age in weeks and Body mass index in Kg/M2. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) using enzymatic colorimetric method aided by Cobass C111 Autoanalyser machine. The Data was analyzed using Epi-info version 3.5.4, CDC, Atlanta, USA and P <0.05 was considered significant. Results: Mean age of the case and control groups were 28.86 + 4.50 Years and 29.9 + 4.95 Years respectively (P = 0.59). Statistical analysis revealed no significant difference in terms of total Cholesterol (P = 0.98) and low density lipoprotein (P = 0.92). However, mean triglycerides (1.95 + 0.89 mmol/L versus 1.02 + 0.51 mmoI/L) was significantly higher in women with pre-eclampsia compared to the control (P= 0.0004) and a significant reduction in high density lipoprotein (0.79± 0.30 mmol/L versus 1.74 + 0.45 mmol/L) in the case group (P = 0.0005). Conclusion: In this study, Pre-eclampsia is associated with elevated serum triglycerides and reduced high density lipoprotein. These findings may serve as screening markers for preeclampsia.},
 year = {2014}
}

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TY  - JOUR
T1  - A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women
AU  - Yakubu Emmanuel Nyam
AU  - Ajen Stephen Anzaku
AU  - Madziga Isa Gamece
AU  - Daru Patrick Haruna
Y1  - 2014/11/24
PY  - 2014
N1  - https://doi.org/10.11648/j.sr.20140206.11
DO  - 10.11648/j.sr.20140206.11
T2  - Science Research
JF  - Science Research
JO  - Science Research
SP  - 150
EP  - 154
PB  - Science Publishing Group
SN  - 2329-0927
UR  - https://doi.org/10.11648/j.sr.20140206.11
AB  - Background: Pre-eclampsia is a hypertensive disorder in pregnancy, that has adverse maternal and perinatal outcomes. Abnormal serum lipid levels have been implicated in the pathogenesis of pre-eclampsia, this can give rise to increased oxidative stress and then subsequently, endothelial dysfunction.  Methods: This study was a comparative cross-sectional study that involved fifty pregnant women that had pre-eclampsia and another fifty healthy pregnant women. Cases and controls were matched for Age in years, Parity, Gestational age in weeks and Body mass index in Kg/M2. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) using enzymatic colorimetric method aided by Cobass C111 Autoanalyser machine. The Data was analyzed using Epi-info version 3.5.4, CDC, Atlanta, USA and P <0.05 was considered significant. Results: Mean age of the case and control groups were 28.86 + 4.50 Years and 29.9 + 4.95 Years respectively (P = 0.59). Statistical analysis revealed no significant difference in terms of total Cholesterol (P = 0.98) and low density lipoprotein (P = 0.92). However, mean triglycerides (1.95 + 0.89 mmol/L versus 1.02 + 0.51 mmoI/L) was significantly higher in women with pre-eclampsia compared to the control (P= 0.0004) and a significant reduction in high density lipoprotein (0.79± 0.30 mmol/L versus 1.74 + 0.45 mmol/L) in the case group (P = 0.0005). Conclusion: In this study, Pre-eclampsia is associated with elevated serum triglycerides and reduced high density lipoprotein. These findings may serve as screening markers for preeclampsia.
VL  - 2
IS  - 6
ER  -

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Author Information

Yakubu Emmanuel Nyam

Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria
Ajen Stephen Anzaku

Department of Obstetrics and Gynaecology, College of Health Sciences, Bingham University, Karu, Jos Campus, Jos, Nigeria
Madziga Isa Gamece

Nigeria National Petroleum Corporation, Kaduna, Nigeria
Daru Patrick Haruna

Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria

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APA Style

Yakubu Emmanuel Nyam, Ajen Stephen Anzaku, Madziga Isa Gamece, Daru Patrick Haruna. (2014). A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women. Science Research, 2(6), 150-154. https://doi.org/10.11648/j.sr.20140206.11

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ACS Style

Yakubu Emmanuel Nyam; Ajen Stephen Anzaku; Madziga Isa Gamece; Daru Patrick Haruna. A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women. Sci. Res. 2014, 2(6), 150-154. doi: 10.11648/j.sr.20140206.11

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AMA Style

Yakubu Emmanuel Nyam, Ajen Stephen Anzaku, Madziga Isa Gamece, Daru Patrick Haruna. A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women. Sci Res. 2014;2(6):150-154. doi: 10.11648/j.sr.20140206.11

Copy | Download

@article{10.11648/j.sr.20140206.11,
  author = {Yakubu Emmanuel Nyam and Ajen Stephen Anzaku and Madziga Isa Gamece and Daru Patrick Haruna},
  title = {A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women},
  journal = {Science Research},
  volume = {2},
  number = {6},
  pages = {150-154},
  doi = {10.11648/j.sr.20140206.11},
  url = {https://doi.org/10.11648/j.sr.20140206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sr.20140206.11},
  abstract = {Background: Pre-eclampsia is a hypertensive disorder in pregnancy, that has adverse maternal and perinatal outcomes. Abnormal serum lipid levels have been implicated in the pathogenesis of pre-eclampsia, this can give rise to increased oxidative stress and then subsequently, endothelial dysfunction.  Methods: This study was a comparative cross-sectional study that involved fifty pregnant women that had pre-eclampsia and another fifty healthy pregnant women. Cases and controls were matched for Age in years, Parity, Gestational age in weeks and Body mass index in Kg/M2. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) using enzymatic colorimetric method aided by Cobass C111 Autoanalyser machine. The Data was analyzed using Epi-info version 3.5.4, CDC, Atlanta, USA and P <0.05 was considered significant. Results: Mean age of the case and control groups were 28.86 + 4.50 Years and 29.9 + 4.95 Years respectively (P = 0.59). Statistical analysis revealed no significant difference in terms of total Cholesterol (P = 0.98) and low density lipoprotein (P = 0.92). However, mean triglycerides (1.95 + 0.89 mmol/L versus 1.02 + 0.51 mmoI/L) was significantly higher in women with pre-eclampsia compared to the control (P= 0.0004) and a significant reduction in high density lipoprotein (0.79± 0.30 mmol/L versus 1.74 + 0.45 mmol/L) in the case group (P = 0.0005). Conclusion: In this study, Pre-eclampsia is associated with elevated serum triglycerides and reduced high density lipoprotein. These findings may serve as screening markers for preeclampsia.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women
AU  - Yakubu Emmanuel Nyam
AU  - Ajen Stephen Anzaku
AU  - Madziga Isa Gamece
AU  - Daru Patrick Haruna
Y1  - 2014/11/24
PY  - 2014
N1  - https://doi.org/10.11648/j.sr.20140206.11
DO  - 10.11648/j.sr.20140206.11
T2  - Science Research
JF  - Science Research
JO  - Science Research
SP  - 150
EP  - 154
PB  - Science Publishing Group
SN  - 2329-0927
UR  - https://doi.org/10.11648/j.sr.20140206.11
AB  - Background: Pre-eclampsia is a hypertensive disorder in pregnancy, that has adverse maternal and perinatal outcomes. Abnormal serum lipid levels have been implicated in the pathogenesis of pre-eclampsia, this can give rise to increased oxidative stress and then subsequently, endothelial dysfunction.  Methods: This study was a comparative cross-sectional study that involved fifty pregnant women that had pre-eclampsia and another fifty healthy pregnant women. Cases and controls were matched for Age in years, Parity, Gestational age in weeks and Body mass index in Kg/M2. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) using enzymatic colorimetric method aided by Cobass C111 Autoanalyser machine. The Data was analyzed using Epi-info version 3.5.4, CDC, Atlanta, USA and P <0.05 was considered significant. Results: Mean age of the case and control groups were 28.86 + 4.50 Years and 29.9 + 4.95 Years respectively (P = 0.59). Statistical analysis revealed no significant difference in terms of total Cholesterol (P = 0.98) and low density lipoprotein (P = 0.92). However, mean triglycerides (1.95 + 0.89 mmol/L versus 1.02 + 0.51 mmoI/L) was significantly higher in women with pre-eclampsia compared to the control (P= 0.0004) and a significant reduction in high density lipoprotein (0.79± 0.30 mmol/L versus 1.74 + 0.45 mmol/L) in the case group (P = 0.0005). Conclusion: In this study, Pre-eclampsia is associated with elevated serum triglycerides and reduced high density lipoprotein. These findings may serve as screening markers for preeclampsia.
VL  - 2
IS  - 6
ER  -

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