Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia

Victor Duniya Sheneni; Dorcas Bolanle James; Sunday Eneojo Atawodi

doi:doi:10.11648/j.sr.20140203.14

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Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia

Victor Duniya Sheneni, Dorcas Bolanle James, Sunday Eneojo Atawodi

Published in Science Research (Volume 2, Issue 3)

Received: 25 April 2014 Accepted: 28 May 2014 Published: 20 June 2014

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Abstract

The hypolipidemic effect of Vitex doniana ethanolic leaves, stem bark and root bark extracts on some biochemical parameters in Poloxamer 407 (P407) induced hyperlipidemic rats was studied for a period of 21 days. Fifty four mixed sex rats weighing 100-200g were divided into nine groups comprising six animals per group: group given feed and water only, group induced by an intra-peritoneal injection of P407 every 48 hours without treatment, groups induced and treated with atorvastatin, leaves, stem bark, root bark extracts and groups of normal rats treated with leaves, stem bark and root bark extracts without induction. In all the groups, P407, atorvastatin, leaves, stem bark and root bark extracts were administered at a dose of 1000mg/kg, 20mg/kg, 100mg/kg, 100mg/kg and 30mg/kg body weight respectively. Blood samples were collected from the rats in all the groups at the end of the 21 days of treatment for determination of serum levels of; aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP), total bilirubin (TB), indirect bilirubin (IB) and direct bilirubin (DB) using Randox kits. Serum concentration of liver marker enzymes (AST, ALT and ALP) was significantly (p<0.05) higher in hyperlipidemic control group when compared to normal control and all treated groups. However there was a significant (p<0.05) decrease and non-significant (p>0.05) change in the levels of these marker enzymes in hyperlipidemic groups treated with the extracts and normal treated groups when compared with the hyperlipidemic and normal control group respectively. There was a significantly (p<0.05) lower level of TP, DB and a significantly (p<0.05) higher level of TB, ID in hyperlipidemic group when compared with rats in the normal control and all treated groups. Normal groups treated with the extracts without induction shows a non-significant (p>0.05) difference in TP, DB, TB and ID when compared with normal control group. These results highlight the efficacy of Vitex doniana (leaves, stem bark and root bark) ethanolic extracts in the amelioration of some undesirable effects of hyperlipidemia.

Published in	Science Research (Volume 2, Issue 3)
DOI	10.11648/j.sr.20140203.14
Page(s)	49-54
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Vitex Doniana, Hyperlipidemia, Poloxamer 407, Biochemical Parameters

References

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APA Style

Victor Duniya Sheneni, Dorcas Bolanle James, Sunday Eneojo Atawodi. (2014). Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia. Science Research, 2(3), 49-54. https://doi.org/10.11648/j.sr.20140203.14

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ACS Style

Victor Duniya Sheneni; Dorcas Bolanle James; Sunday Eneojo Atawodi. Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia. Sci. Res. 2014, 2(3), 49-54. doi: 10.11648/j.sr.20140203.14

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AMA Style

Victor Duniya Sheneni, Dorcas Bolanle James, Sunday Eneojo Atawodi. Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia. Sci Res. 2014;2(3):49-54. doi: 10.11648/j.sr.20140203.14

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@article{10.11648/j.sr.20140203.14,
  author = {Victor Duniya Sheneni and Dorcas Bolanle James and Sunday Eneojo Atawodi},
  title = {Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia},
  journal = {Science Research},
  volume = {2},
  number = {3},
  pages = {49-54},
  doi = {10.11648/j.sr.20140203.14},
  url = {https://doi.org/10.11648/j.sr.20140203.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sr.20140203.14},
  abstract = {The hypolipidemic effect of Vitex doniana ethanolic leaves, stem bark and root bark extracts on some biochemical parameters in Poloxamer 407 (P407) induced hyperlipidemic rats was studied for a period of 21 days. Fifty four mixed sex rats weighing 100-200g were divided into nine groups comprising six animals per group: group given feed and water only, group induced by an intra-peritoneal injection of P407 every 48 hours without treatment, groups induced and treated with atorvastatin, leaves, stem bark, root bark extracts and groups of normal rats treated with leaves, stem bark and root bark extracts without induction. In all the groups, P407, atorvastatin, leaves, stem bark and root bark extracts were administered at a dose of 1000mg/kg, 20mg/kg, 100mg/kg, 100mg/kg and 30mg/kg body weight respectively. Blood samples were collected from the rats in all the groups at the end of the 21 days of treatment for determination of serum levels of; aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP), total bilirubin (TB), indirect bilirubin (IB) and direct bilirubin (DB) using Randox kits. Serum concentration of liver marker enzymes (AST, ALT and ALP) was significantly (p0.05) change in the levels of these marker enzymes in hyperlipidemic groups treated with the extracts and normal treated groups when compared with the hyperlipidemic and normal control group respectively. There was a significantly (p0.05) difference in TP, DB, TB and ID when compared with normal control group. These results highlight the efficacy of Vitex doniana (leaves, stem bark and root bark) ethanolic extracts in the amelioration of some undesirable effects of hyperlipidemia.},
 year = {2014}
}

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TY  - JOUR
T1  - Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia
AU  - Victor Duniya Sheneni
AU  - Dorcas Bolanle James
AU  - Sunday Eneojo Atawodi
Y1  - 2014/06/20
PY  - 2014
N1  - https://doi.org/10.11648/j.sr.20140203.14
DO  - 10.11648/j.sr.20140203.14
T2  - Science Research
JF  - Science Research
JO  - Science Research
SP  - 49
EP  - 54
PB  - Science Publishing Group
SN  - 2329-0927
UR  - https://doi.org/10.11648/j.sr.20140203.14
AB  - The hypolipidemic effect of Vitex doniana ethanolic leaves, stem bark and root bark extracts on some biochemical parameters in Poloxamer 407 (P407) induced hyperlipidemic rats was studied for a period of 21 days. Fifty four mixed sex rats weighing 100-200g were divided into nine groups comprising six animals per group: group given feed and water only, group induced by an intra-peritoneal injection of P407 every 48 hours without treatment, groups induced and treated with atorvastatin, leaves, stem bark, root bark extracts and groups of normal rats treated with leaves, stem bark and root bark extracts without induction. In all the groups, P407, atorvastatin, leaves, stem bark and root bark extracts were administered at a dose of 1000mg/kg, 20mg/kg, 100mg/kg, 100mg/kg and 30mg/kg body weight respectively. Blood samples were collected from the rats in all the groups at the end of the 21 days of treatment for determination of serum levels of; aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP), total bilirubin (TB), indirect bilirubin (IB) and direct bilirubin (DB) using Randox kits. Serum concentration of liver marker enzymes (AST, ALT and ALP) was significantly (p0.05) change in the levels of these marker enzymes in hyperlipidemic groups treated with the extracts and normal treated groups when compared with the hyperlipidemic and normal control group respectively. There was a significantly (p0.05) difference in TP, DB, TB and ID when compared with normal control group. These results highlight the efficacy of Vitex doniana (leaves, stem bark and root bark) ethanolic extracts in the amelioration of some undesirable effects of hyperlipidemia.
VL  - 2
IS  - 3
ER  -

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Author Information

Victor Duniya Sheneni

Department of Biochemistry, Ahmadu Bello University, Samaru Zaria, Nigeria
Dorcas Bolanle James

Department of Biochemistry, Ahmadu Bello University, Samaru Zaria, Nigeria
Sunday Eneojo Atawodi

Department of Biochemistry, Ahmadu Bello University, Samaru Zaria, Nigeria

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APA Style

Victor Duniya Sheneni, Dorcas Bolanle James, Sunday Eneojo Atawodi. (2014). Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia. Science Research, 2(3), 49-54. https://doi.org/10.11648/j.sr.20140203.14

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ACS Style

Victor Duniya Sheneni; Dorcas Bolanle James; Sunday Eneojo Atawodi. Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia. Sci. Res. 2014, 2(3), 49-54. doi: 10.11648/j.sr.20140203.14

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AMA Style

Victor Duniya Sheneni, Dorcas Bolanle James, Sunday Eneojo Atawodi. Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia. Sci Res. 2014;2(3):49-54. doi: 10.11648/j.sr.20140203.14

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@article{10.11648/j.sr.20140203.14,
  author = {Victor Duniya Sheneni and Dorcas Bolanle James and Sunday Eneojo Atawodi},
  title = {Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia},
  journal = {Science Research},
  volume = {2},
  number = {3},
  pages = {49-54},
  doi = {10.11648/j.sr.20140203.14},
  url = {https://doi.org/10.11648/j.sr.20140203.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sr.20140203.14},
  abstract = {The hypolipidemic effect of Vitex doniana ethanolic leaves, stem bark and root bark extracts on some biochemical parameters in Poloxamer 407 (P407) induced hyperlipidemic rats was studied for a period of 21 days. Fifty four mixed sex rats weighing 100-200g were divided into nine groups comprising six animals per group: group given feed and water only, group induced by an intra-peritoneal injection of P407 every 48 hours without treatment, groups induced and treated with atorvastatin, leaves, stem bark, root bark extracts and groups of normal rats treated with leaves, stem bark and root bark extracts without induction. In all the groups, P407, atorvastatin, leaves, stem bark and root bark extracts were administered at a dose of 1000mg/kg, 20mg/kg, 100mg/kg, 100mg/kg and 30mg/kg body weight respectively. Blood samples were collected from the rats in all the groups at the end of the 21 days of treatment for determination of serum levels of; aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP), total bilirubin (TB), indirect bilirubin (IB) and direct bilirubin (DB) using Randox kits. Serum concentration of liver marker enzymes (AST, ALT and ALP) was significantly (p0.05) change in the levels of these marker enzymes in hyperlipidemic groups treated with the extracts and normal treated groups when compared with the hyperlipidemic and normal control group respectively. There was a significantly (p0.05) difference in TP, DB, TB and ID when compared with normal control group. These results highlight the efficacy of Vitex doniana (leaves, stem bark and root bark) ethanolic extracts in the amelioration of some undesirable effects of hyperlipidemia.},
 year = {2014}
}

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TY  - JOUR
T1  - Ethanolic Extracts of Vitex Doniana Possesses Hepatocuractive Property in Poloxamer Induced Hyperlipidemia
AU  - Victor Duniya Sheneni
AU  - Dorcas Bolanle James
AU  - Sunday Eneojo Atawodi
Y1  - 2014/06/20
PY  - 2014
N1  - https://doi.org/10.11648/j.sr.20140203.14
DO  - 10.11648/j.sr.20140203.14
T2  - Science Research
JF  - Science Research
JO  - Science Research
SP  - 49
EP  - 54
PB  - Science Publishing Group
SN  - 2329-0927
UR  - https://doi.org/10.11648/j.sr.20140203.14
AB  - The hypolipidemic effect of Vitex doniana ethanolic leaves, stem bark and root bark extracts on some biochemical parameters in Poloxamer 407 (P407) induced hyperlipidemic rats was studied for a period of 21 days. Fifty four mixed sex rats weighing 100-200g were divided into nine groups comprising six animals per group: group given feed and water only, group induced by an intra-peritoneal injection of P407 every 48 hours without treatment, groups induced and treated with atorvastatin, leaves, stem bark, root bark extracts and groups of normal rats treated with leaves, stem bark and root bark extracts without induction. In all the groups, P407, atorvastatin, leaves, stem bark and root bark extracts were administered at a dose of 1000mg/kg, 20mg/kg, 100mg/kg, 100mg/kg and 30mg/kg body weight respectively. Blood samples were collected from the rats in all the groups at the end of the 21 days of treatment for determination of serum levels of; aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP), total bilirubin (TB), indirect bilirubin (IB) and direct bilirubin (DB) using Randox kits. Serum concentration of liver marker enzymes (AST, ALT and ALP) was significantly (p0.05) change in the levels of these marker enzymes in hyperlipidemic groups treated with the extracts and normal treated groups when compared with the hyperlipidemic and normal control group respectively. There was a significantly (p0.05) difference in TP, DB, TB and ID when compared with normal control group. These results highlight the efficacy of Vitex doniana (leaves, stem bark and root bark) ethanolic extracts in the amelioration of some undesirable effects of hyperlipidemia.
VL  - 2
IS  - 3
ER  -

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