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Levshenko T. Toxicologic and Hygienic Characteristics of p-373-2-20; p-5003-ac;p-294-2-35 Polyols and Prognosis of Their Potential Danger for Environment.

Received: 10 April 2013     Published: 20 May 2013
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Abstract

Studied the toxic effects polyoxipropylenpolyols in acute and subacute experiments on warm-blooded animals. It is established that they are pertained to the IV hazard class; have polytropic general toxic effect; on the level of toxic doses they influence on the generative function and the genetic apparatus; inhibit and disrupt the interaction between the cellular and humoral immunity.Experiments were performed on adult Wistar white rats, white mouses, guinea pigs, hybrid mouse lines BALB / C, (SBAc57BL) F1, CBA / Lac, and rabbits of the chinchilla race [4-6]. The objects of the investigation were polyoxipropylenthriols with molecular masses 5000M (P-5003-AC), and 370M (P-373-2-20), and polyoxipropylated amine with molecular mass 290M (P-294-2-35). Polyoxipropylenpolyols P-5003-AC, P-373-2-20 and P-294-2-35 in doses of 1/10 and 1/100 DL50 have a toxic effect on the generatic function and the genetic apparatus, and in doses 1/10, 1/100 and 1/1000 DL50 inhibit and disrupt the cooperative interaction of cellular and humoral immunity. In all cases, the dose of 1/10000 DL50 was inoperative, it is equal to 3.23; 3.62 and 1.48 mg / kg of animal weight, respectively, for P-373-2-20, P-5003-AC and P-294-2- 35.

Published in Science Research (Volume 1, Issue 2)
DOI 10.11648/j.sr.20130102.14
Page(s) 31-34
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Xenobiotics, General Toxic Effect, the Specific Types of Biological Effects

References
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    Zhukov V., Telegin V., Rezunenko Y., Zaytseva O., Knigavko V., et al. (2013). Levshenko T. Toxicologic and Hygienic Characteristics of p-373-2-20; p-5003-ac;p-294-2-35 Polyols and Prognosis of Their Potential Danger for Environment.. Science Research, 1(2), 31-34. https://doi.org/10.11648/j.sr.20130102.14

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    ACS Style

    Zhukov V.; Telegin V.; Rezunenko Y.; Zaytseva O.; Knigavko V., et al. Levshenko T. Toxicologic and Hygienic Characteristics of p-373-2-20; p-5003-ac;p-294-2-35 Polyols and Prognosis of Their Potential Danger for Environment.. Sci. Res. 2013, 1(2), 31-34. doi: 10.11648/j.sr.20130102.14

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    AMA Style

    Zhukov V., Telegin V., Rezunenko Y., Zaytseva O., Knigavko V., et al. Levshenko T. Toxicologic and Hygienic Characteristics of p-373-2-20; p-5003-ac;p-294-2-35 Polyols and Prognosis of Their Potential Danger for Environment.. Sci Res. 2013;1(2):31-34. doi: 10.11648/j.sr.20130102.14

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  • @article{10.11648/j.sr.20130102.14,
      author = {Zhukov V. and Telegin V. and Rezunenko Y. and Zaytseva O. and Knigavko V. and Grankina S. and Levshenko T.},
      title = {Levshenko T. Toxicologic and Hygienic Characteristics of p-373-2-20; p-5003-ac;p-294-2-35 Polyols and Prognosis of Their Potential Danger for Environment.},
      journal = {Science Research},
      volume = {1},
      number = {2},
      pages = {31-34},
      doi = {10.11648/j.sr.20130102.14},
      url = {https://doi.org/10.11648/j.sr.20130102.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sr.20130102.14},
      abstract = {Studied the toxic effects polyoxipropylenpolyols in acute and subacute experiments on warm-blooded animals. It is established that they are pertained to the IV hazard class; have polytropic general toxic effect; on the level of toxic doses they influence on the generative function and the genetic apparatus; inhibit and disrupt the interaction between the cellular and humoral immunity.Experiments were performed on adult Wistar white rats, white mouses, guinea pigs, hybrid mouse lines BALB / C, (SBAc57BL) F1, CBA / Lac, and rabbits of the chinchilla race [4-6]. The objects of the investigation were polyoxipropylenthriols with molecular masses 5000M (P-5003-AC), and 370M (P-373-2-20), and polyoxipropylated amine with molecular mass 290M (P-294-2-35).  Polyoxipropylenpolyols P-5003-AC, P-373-2-20 and P-294-2-35 in doses of 1/10 and 1/100 DL50 have a toxic effect on the generatic function and the genetic apparatus, and in doses 1/10, 1/100 and 1/1000 DL50 inhibit and disrupt the cooperative interaction of cellular and humoral immunity. In all cases, the dose of 1/10000 DL50 was inoperative, it is equal to 3.23; 3.62 and 1.48 mg / kg of animal weight, respectively, for P-373-2-20, P-5003-AC and P-294-2- 35.},
     year = {2013}
    }
    

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  • TY  - JOUR
    T1  - Levshenko T. Toxicologic and Hygienic Characteristics of p-373-2-20; p-5003-ac;p-294-2-35 Polyols and Prognosis of Their Potential Danger for Environment.
    AU  - Zhukov V.
    AU  - Telegin V.
    AU  - Rezunenko Y.
    AU  - Zaytseva O.
    AU  - Knigavko V.
    AU  - Grankina S.
    AU  - Levshenko T.
    Y1  - 2013/05/20
    PY  - 2013
    N1  - https://doi.org/10.11648/j.sr.20130102.14
    DO  - 10.11648/j.sr.20130102.14
    T2  - Science Research
    JF  - Science Research
    JO  - Science Research
    SP  - 31
    EP  - 34
    PB  - Science Publishing Group
    SN  - 2329-0927
    UR  - https://doi.org/10.11648/j.sr.20130102.14
    AB  - Studied the toxic effects polyoxipropylenpolyols in acute and subacute experiments on warm-blooded animals. It is established that they are pertained to the IV hazard class; have polytropic general toxic effect; on the level of toxic doses they influence on the generative function and the genetic apparatus; inhibit and disrupt the interaction between the cellular and humoral immunity.Experiments were performed on adult Wistar white rats, white mouses, guinea pigs, hybrid mouse lines BALB / C, (SBAc57BL) F1, CBA / Lac, and rabbits of the chinchilla race [4-6]. The objects of the investigation were polyoxipropylenthriols with molecular masses 5000M (P-5003-AC), and 370M (P-373-2-20), and polyoxipropylated amine with molecular mass 290M (P-294-2-35).  Polyoxipropylenpolyols P-5003-AC, P-373-2-20 and P-294-2-35 in doses of 1/10 and 1/100 DL50 have a toxic effect on the generatic function and the genetic apparatus, and in doses 1/10, 1/100 and 1/1000 DL50 inhibit and disrupt the cooperative interaction of cellular and humoral immunity. In all cases, the dose of 1/10000 DL50 was inoperative, it is equal to 3.23; 3.62 and 1.48 mg / kg of animal weight, respectively, for P-373-2-20, P-5003-AC and P-294-2- 35.
    VL  - 1
    IS  - 2
    ER  - 

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Author Information
  • Kharkiv National Medical University, Kharkiv, Ukraine, Department of Biochemistry

  • Kharkiv National Medical University, Kharkiv, Ukraine, Department of Biochemistry

  • Kharkiv National Medical University, Kharkiv, Ukraine, Department of Biochemistry

  • Kharkiv National Medical University, Kharkiv, Ukraine, Department of Medical and Biology Physics

  • Kharkiv National Medical University, Kharkiv, Ukraine, Department of Medical and Biology Physics

  • Kharkiv National Medical University, Kharkiv, Ukraine, Department of Medical and Biology Physics

  • Kharkiv National Medical University, Kharkiv, Ukraine, Department of Medical and Biology Physics

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