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Evaluation of Biological Parameters of Diabetic Patients Treated with Medicinal Plants: Case of the City of N'Djamena

Received: 8 October 2022     Accepted: 27 October 2022     Published: 10 November 2022
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Abstract

Diabetes is a metabolic disorder related to the secretion and / or absorption of insulin by the body, it is characterized mainly by a high level of glucose in the blood beyond 1.10 g / l. The objective of this study is to contribute to the development of medicinal plants that can help in the management of diabetes mellitus. The data collected during this study were done through a direct interview on the basis of an ethnobotanical survey form. The data of the study were analyzed on Excel and then SPSS version 22.0. Blood samples of 30 diabetic patients of both sexes subjected to plant-based treatments were collected. The different assays were performed at time 0 and 8 weeks after the first sample. The average age of the patients was 44.13 years with extremes of 18 and 70 years and a male predominance at 56%. Twenty-three medicinal plants were identified, 6 of which were used in the composition of three recipes for diabetic patients. The recipe composed of Leptadenia hastata + Guiera senegalensis had a 100% favorable effect on the carbohydrate parameters. On the other hand, the recipe composed of Boscia senegalensis+Anogeissus leiocarpus+Guiera senegalensis and the one composed of Prosopis africana+ Indigofera astragalana + Guiera senegalensis had a 57.1% and 55.6% favorable effect respectively on the carbohydrate parameters by restoring the glycemic balance All these 3 recipes had no toxic effect on the liver and kidneys: transaminases and creatine remained stable. A phytochemical and pharmacological study on animals with these plants will allow the development of phytomedicines against diabetes.

Published in Journal of Diseases and Medicinal Plants (Volume 8, Issue 4)
DOI 10.11648/j.jdmp.20220804.11
Page(s) 66-73
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Medicinal Plants, Diabetic Patients, N'Djamena, Chad

References
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[2] WHO, 2015: Expert Committee on Diabetes. Good practice guidelines in diabetes for practitioners. RepDemAlg and pop. Extranet. Echo int. 2015. Accessed August 23, 2020.
[3] IDF. Global estimates of the prevelance of diabetes for 2011 and 2030. Diabetes research and clinical practice, 2011; 94: 311-2.
[4] Brahim B. 0, Dionadji M. Mouanadji M. Ndoutemia G. Batakao G. Pathé M. O. Mean values of blood parameters of the rural population in Chari Baguirmi, Chad. Med Afr Noire, 2002; 7: 321 - 325.
[5] Brahim BO, Dionodji M, Mouanodji M, Batakao G, Pathé MD. Lipid profile of the population aged over 55 in the city of N'Djamena. Med Afr noire, 2004; 51 (6): 367-9.
[6] WHO. General methodological principles for research and evaluation of traditional medicine. WHO/TRM/2000; Annex II: 31-35.
[7] Awale P. Diabetes and traditional medicine in Africa, Diabetesvoice, 2006; 51: 24-26.
[8] Paul Iserin. Encilopedia of medecinal plants. (2nded). 335p.
[9] Ernst E. Plants with hypoglycaemic activity in human phytomedicine, 1997; 4 (1): 73-80.
[10] Kadebe Zoua. Study of the antidiabetic and hypolipidemic effect of total extract and fractions of Plumeria alba linn in Dawley sprague rat and ICR mouse. PhD thesis,, 2014; University of Lome, 120p.
[11] Oksom S. JB, 2010. Pharmacological evaluation of Gardenia ternifolia and Hymenocardia acida extracts, plants with antidiabetic activation. DEA of Pharmacology, University of Lome, 61p.
[12] Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systemic review, Drugs, 2001; 61: 2163-2175.
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[14] Motobessengar N. Contribution of traditional medicine in the management of diabetes in Chad: case of the commune of N'Djamena. Thesis of medicine, 2020; University of N’Djamena,: 91p.
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[18] Ouafae Benkhnigue, Fatiha Ben Akka, Souad Salhi, Mohamed Fadli, Allal Douira et Lahcen Zidane. Catalog of medicinal plants used in the treatment of diabetes in the region d’Al Haouz-Rhamna (Maroc). Journal of Animal &Plant Sciences, 2014; vol. 23, 1: 3539-3568, ISSN 2071-7024.
[19] Alia Telli, Marie-Andrée Esnault et Aminata Ould El Hadj Khelil. An ethnopharmacological survey of plants used in traditional diabetes treatment in south-eastern Algeria (Ouargla province). Journal of Arid Environments 2013; 127: 82-92.
[20] Gbodossou E. Extracts of medicinal plants in the treatment of diabetic diseases. PCT (WO 02/094299 A1), Sénégal, 2002.
[21] David M, Fidel N, Oulianovie G. K, Abba T, Mohamad P. K. Glucose-lowering potential of Guiera senegalensis roots in diabetic rat model. Avienna journal of phytomedecine. Cameroun: 2020; 653-663.
[22] Keita A. Mariko, E. Haidara, T. K., Study of the hypoglycemic activity of sclerocarya birrea (A. Rich) Hochst. (Anacardiaceae). pharm. méd. Trad. Afr. Bamako. 1998; Vol 10: 16-25.
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  • APA Style

    Elise Dagosse, Memti Mberdoum Nguinambaye, Nadjioroum Ngam Asra, Brahim Boy Otchom. (2022). Evaluation of Biological Parameters of Diabetic Patients Treated with Medicinal Plants: Case of the City of N'Djamena. Journal of Diseases and Medicinal Plants, 8(4), 66-73. https://doi.org/10.11648/j.jdmp.20220804.11

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    ACS Style

    Elise Dagosse; Memti Mberdoum Nguinambaye; Nadjioroum Ngam Asra; Brahim Boy Otchom. Evaluation of Biological Parameters of Diabetic Patients Treated with Medicinal Plants: Case of the City of N'Djamena. J. Dis. Med. Plants 2022, 8(4), 66-73. doi: 10.11648/j.jdmp.20220804.11

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    AMA Style

    Elise Dagosse, Memti Mberdoum Nguinambaye, Nadjioroum Ngam Asra, Brahim Boy Otchom. Evaluation of Biological Parameters of Diabetic Patients Treated with Medicinal Plants: Case of the City of N'Djamena. J Dis Med Plants. 2022;8(4):66-73. doi: 10.11648/j.jdmp.20220804.11

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  • @article{10.11648/j.jdmp.20220804.11,
      author = {Elise Dagosse and Memti Mberdoum Nguinambaye and Nadjioroum Ngam Asra and Brahim Boy Otchom},
      title = {Evaluation of Biological Parameters of Diabetic Patients Treated with Medicinal Plants: Case of the City of N'Djamena},
      journal = {Journal of Diseases and Medicinal Plants},
      volume = {8},
      number = {4},
      pages = {66-73},
      doi = {10.11648/j.jdmp.20220804.11},
      url = {https://doi.org/10.11648/j.jdmp.20220804.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20220804.11},
      abstract = {Diabetes is a metabolic disorder related to the secretion and / or absorption of insulin by the body, it is characterized mainly by a high level of glucose in the blood beyond 1.10 g / l. The objective of this study is to contribute to the development of medicinal plants that can help in the management of diabetes mellitus. The data collected during this study were done through a direct interview on the basis of an ethnobotanical survey form. The data of the study were analyzed on Excel and then SPSS version 22.0. Blood samples of 30 diabetic patients of both sexes subjected to plant-based treatments were collected. The different assays were performed at time 0 and 8 weeks after the first sample. The average age of the patients was 44.13 years with extremes of 18 and 70 years and a male predominance at 56%. Twenty-three medicinal plants were identified, 6 of which were used in the composition of three recipes for diabetic patients. The recipe composed of Leptadenia hastata + Guiera senegalensis had a 100% favorable effect on the carbohydrate parameters. On the other hand, the recipe composed of Boscia senegalensis+Anogeissus leiocarpus+Guiera senegalensis and the one composed of Prosopis africana+ Indigofera astragalana + Guiera senegalensis had a 57.1% and 55.6% favorable effect respectively on the carbohydrate parameters by restoring the glycemic balance All these 3 recipes had no toxic effect on the liver and kidneys: transaminases and creatine remained stable. A phytochemical and pharmacological study on animals with these plants will allow the development of phytomedicines against diabetes.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Evaluation of Biological Parameters of Diabetic Patients Treated with Medicinal Plants: Case of the City of N'Djamena
    AU  - Elise Dagosse
    AU  - Memti Mberdoum Nguinambaye
    AU  - Nadjioroum Ngam Asra
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    DO  - 10.11648/j.jdmp.20220804.11
    T2  - Journal of Diseases and Medicinal Plants
    JF  - Journal of Diseases and Medicinal Plants
    JO  - Journal of Diseases and Medicinal Plants
    SP  - 66
    EP  - 73
    PB  - Science Publishing Group
    SN  - 2469-8210
    UR  - https://doi.org/10.11648/j.jdmp.20220804.11
    AB  - Diabetes is a metabolic disorder related to the secretion and / or absorption of insulin by the body, it is characterized mainly by a high level of glucose in the blood beyond 1.10 g / l. The objective of this study is to contribute to the development of medicinal plants that can help in the management of diabetes mellitus. The data collected during this study were done through a direct interview on the basis of an ethnobotanical survey form. The data of the study were analyzed on Excel and then SPSS version 22.0. Blood samples of 30 diabetic patients of both sexes subjected to plant-based treatments were collected. The different assays were performed at time 0 and 8 weeks after the first sample. The average age of the patients was 44.13 years with extremes of 18 and 70 years and a male predominance at 56%. Twenty-three medicinal plants were identified, 6 of which were used in the composition of three recipes for diabetic patients. The recipe composed of Leptadenia hastata + Guiera senegalensis had a 100% favorable effect on the carbohydrate parameters. On the other hand, the recipe composed of Boscia senegalensis+Anogeissus leiocarpus+Guiera senegalensis and the one composed of Prosopis africana+ Indigofera astragalana + Guiera senegalensis had a 57.1% and 55.6% favorable effect respectively on the carbohydrate parameters by restoring the glycemic balance All these 3 recipes had no toxic effect on the liver and kidneys: transaminases and creatine remained stable. A phytochemical and pharmacological study on animals with these plants will allow the development of phytomedicines against diabetes.
    VL  - 8
    IS  - 4
    ER  - 

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Author Information
  • Department of Biomedical, Pharmaceutical, Nursing and Nutritional Sciences, University Touma?, N'Djamena, Chad

  • Department of Biological Sciences, Faculty of Exact and Applied Sciences, University of N’Djamena, N’Djamena, Chad

  • Department of Biomedical, Faculty of Human Health Sciences, University of N’Djamena, N'Djamena, Chad

  • Department of Biomedical, Pharmaceutical, Nursing and Nutritional Sciences, University Touma?, N'Djamena, Chad

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