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Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar

Received: 22 February 2021     Accepted: 8 March 2021     Published: 26 March 2021
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Abstract

Arthritis is an autoimmune disease characterized by joint inflammation, the treatment of this disease requires the use of non-steroidal or steroidal anti-inflammatory drugs. Given the many side effects associated with conventional anti-inflammatory drugs, the use of herbal medicines would benefit patients. Mitracarpus scaber (Rubiaceae), is a herb whose leaves are used to treat skin conditions and relieve pain in the limbs. To elucidate the traditional use of the aerial parts of M. scaber, the present study was conducted on arthritic rats induced by Freund's complete adjuvant. Arthritis was induced in Wistar rats by injecting Freund's complete adjuvant solution into the right hind leg. Diclofenac and Celebrex were chosen as reference molecules. Administration of Diclofenac (5 mg/kg body weight) and Celebrex (10 mg/kg body weight) and the aqueous extract of the aerial parts of M. scaber at doses of 200; 400 and 800 mg/kg body weight began the day after injection and continued for 20 days. Leg swelling, biochemical and hematological parameters as well as fibrinogen levels were evaluated. Oral administration of the extract significantly suppressed inflammatory responses in the joints of arthritic rats. It did not cause liver damage in the rats during the twenty (20) days of treatment. These results indicate that the aqueous extract of the aerial parts of M. scaber prevents the pathological development of arthritis in rats. The active ingredients present in the extract could be potential agents for the treatment of inflammation and arthritis.

Published in Journal of Diseases and Medicinal Plants (Volume 7, Issue 1)
DOI 10.11648/j.jdmp.20210701.14
Page(s) 22-29
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Mitracarpus scaber, Arthritis, Anti-inflammatory

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Cite This Article
  • APA Style

    Georges Abizi, Ouattara-Soro Fatou Scherazade, Ernest Zougrou N’guessan, John Kouadio Kouakou, Emile Begbin Kouassi, et al. (2021). Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar. Journal of Diseases and Medicinal Plants, 7(1), 22-29. https://doi.org/10.11648/j.jdmp.20210701.14

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    ACS Style

    Georges Abizi; Ouattara-Soro Fatou Scherazade; Ernest Zougrou N’guessan; John Kouadio Kouakou; Emile Begbin Kouassi, et al. Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar. J. Dis. Med. Plants 2021, 7(1), 22-29. doi: 10.11648/j.jdmp.20210701.14

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    AMA Style

    Georges Abizi, Ouattara-Soro Fatou Scherazade, Ernest Zougrou N’guessan, John Kouadio Kouakou, Emile Begbin Kouassi, et al. Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar. J Dis Med Plants. 2021;7(1):22-29. doi: 10.11648/j.jdmp.20210701.14

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  • @article{10.11648/j.jdmp.20210701.14,
      author = {Georges Abizi and Ouattara-Soro Fatou Scherazade and Ernest Zougrou N’guessan and John Kouadio Kouakou and Emile Begbin Kouassi and Sévérin Koffi and Jean-Jacques Kablan Kassi and Alassane Koné},
      title = {Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar},
      journal = {Journal of Diseases and Medicinal Plants},
      volume = {7},
      number = {1},
      pages = {22-29},
      doi = {10.11648/j.jdmp.20210701.14},
      url = {https://doi.org/10.11648/j.jdmp.20210701.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20210701.14},
      abstract = {Arthritis is an autoimmune disease characterized by joint inflammation, the treatment of this disease requires the use of non-steroidal or steroidal anti-inflammatory drugs. Given the many side effects associated with conventional anti-inflammatory drugs, the use of herbal medicines would benefit patients. Mitracarpus scaber (Rubiaceae), is a herb whose leaves are used to treat skin conditions and relieve pain in the limbs. To elucidate the traditional use of the aerial parts of M. scaber, the present study was conducted on arthritic rats induced by Freund's complete adjuvant. Arthritis was induced in Wistar rats by injecting Freund's complete adjuvant solution into the right hind leg. Diclofenac and Celebrex were chosen as reference molecules. Administration of Diclofenac (5 mg/kg body weight) and Celebrex (10 mg/kg body weight) and the aqueous extract of the aerial parts of M. scaber at doses of 200; 400 and 800 mg/kg body weight began the day after injection and continued for 20 days. Leg swelling, biochemical and hematological parameters as well as fibrinogen levels were evaluated. Oral administration of the extract significantly suppressed inflammatory responses in the joints of arthritic rats. It did not cause liver damage in the rats during the twenty (20) days of treatment. These results indicate that the aqueous extract of the aerial parts of M. scaber prevents the pathological development of arthritis in rats. The active ingredients present in the extract could be potential agents for the treatment of inflammation and arthritis.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Anti-arthritic Activity of the Aqueous Extract of the Aerial Parts of Mitracarpus scaber (Rubiaceae) Zucc in Rats Wistar
    AU  - Georges Abizi
    AU  - Ouattara-Soro Fatou Scherazade
    AU  - Ernest Zougrou N’guessan
    AU  - John Kouadio Kouakou
    AU  - Emile Begbin Kouassi
    AU  - Sévérin Koffi
    AU  - Jean-Jacques Kablan Kassi
    AU  - Alassane Koné
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    PY  - 2021
    N1  - https://doi.org/10.11648/j.jdmp.20210701.14
    DO  - 10.11648/j.jdmp.20210701.14
    T2  - Journal of Diseases and Medicinal Plants
    JF  - Journal of Diseases and Medicinal Plants
    JO  - Journal of Diseases and Medicinal Plants
    SP  - 22
    EP  - 29
    PB  - Science Publishing Group
    SN  - 2469-8210
    UR  - https://doi.org/10.11648/j.jdmp.20210701.14
    AB  - Arthritis is an autoimmune disease characterized by joint inflammation, the treatment of this disease requires the use of non-steroidal or steroidal anti-inflammatory drugs. Given the many side effects associated with conventional anti-inflammatory drugs, the use of herbal medicines would benefit patients. Mitracarpus scaber (Rubiaceae), is a herb whose leaves are used to treat skin conditions and relieve pain in the limbs. To elucidate the traditional use of the aerial parts of M. scaber, the present study was conducted on arthritic rats induced by Freund's complete adjuvant. Arthritis was induced in Wistar rats by injecting Freund's complete adjuvant solution into the right hind leg. Diclofenac and Celebrex were chosen as reference molecules. Administration of Diclofenac (5 mg/kg body weight) and Celebrex (10 mg/kg body weight) and the aqueous extract of the aerial parts of M. scaber at doses of 200; 400 and 800 mg/kg body weight began the day after injection and continued for 20 days. Leg swelling, biochemical and hematological parameters as well as fibrinogen levels were evaluated. Oral administration of the extract significantly suppressed inflammatory responses in the joints of arthritic rats. It did not cause liver damage in the rats during the twenty (20) days of treatment. These results indicate that the aqueous extract of the aerial parts of M. scaber prevents the pathological development of arthritis in rats. The active ingredients present in the extract could be potential agents for the treatment of inflammation and arthritis.
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • Laboratory of Biology and Health, University Felix Houphouet-Boigny (UFHB), Abidjan, Cote d’Ivoire

  • Laboratory of Biology and Health, University Felix Houphouet-Boigny (UFHB), Abidjan, Cote d’Ivoire

  • Laboratory of Biology and Health, University Felix Houphouet-Boigny (UFHB), Abidjan, Cote d’Ivoire

  • Laboratory of Biology and Health, University Felix Houphouet-Boigny (UFHB), Abidjan, Cote d’Ivoire

  • Laboratory of Biology and Health, University Felix Houphouet-Boigny (UFHB), Abidjan, Cote d’Ivoire

  • Laboratory of Biology and Health, University Felix Houphouet-Boigny (UFHB), Abidjan, Cote d’Ivoire

  • Laboratory of Biology and Health, University Felix Houphouet-Boigny (UFHB), Abidjan, Cote d’Ivoire

  • Laboratory of Biology and Health, University Felix Houphouet-Boigny (UFHB), Abidjan, Cote d’Ivoire

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