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Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract

Received: 13 August 2019     Accepted: 5 September 2019     Published: 12 October 2019
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Abstract

The haematopoietic potential of Jatropha tanjorensis leaf extract in Plasmodium berghi-berghi infected mice treated with Hippocratea africana root bark extract was investigated. Thirty (21) adult mice weighing 27 – 33g were divided into seven (7) groups with three (3) animals in each group. Group 1 served as normal control while Groups 2 – 7 were parasitized with Plasmodium berghi-berghi and Group 2 was the test control (parasitized and untreated) group. Group 3 was administered 8mg/kg bw of artemether-lumefantrine for 3 days. Group 4 and 5 received daily, 200mg/kg bw and 300mg/kg bw of extracts of Hippocratea africana and Jatropha tanjorensis respectively for 4 days. Group 6 received 8mg/kg bw of artemether-lumefantrine for 3 days followed with 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Group 7 was treated with 200mg/kg bw of Hippocratea africana root extract for 4 days followed by 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Significant anti-plasmodial activity was observed with artemether-lumefantrine and Hippocratea africana root bark extract administration. Plasmodium berghi-berghi infection induced alterations in haematological indices such as decreased RBC count, platelet count, haemoglobin concentration and heamatocrit and increased WBC count. Administration of Jatropha tanjorensis leaf extract showed improved haematological indices particularly in the red blood cell counts and haemoglobin concentration. Jatropha tanjorensis has haematopoietic activity in Plasmodium berghi-berghi infected mice treated Hippocratea africana root bark extract.

Published in Journal of Diseases and Medicinal Plants (Volume 5, Issue 4)
DOI 10.11648/j.jdmp.20190504.12
Page(s) 69-73
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Jatropha tanjorensis, Hippocratea africana, Artemether-Lumefantrine, Antiplasmodial Activity, Haemato-protection

References
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[2] Ndem, J. I. and Bassey, U. E. 2017. Parasitaemia Reduction and Moderately Improved Haematological Indices Potentials of Hippocratea africana Root Bark Extract in Plasmodium berghei-berghei Infected Mice. World Journal of Pharmaceutical Research, 6 (4): 63-74.
[3] Ijarotimi, S., Agbedahunsi, J. M., Onyeji, C. O. and Adewunmi, C. O. 2010. Chemotherapeutic action between Khaya grandifoliola steam bark extract and two antimalarial drugs in mice. African journal of traditional, complementary and alternative medicine, 7 (4): 370-376.
[4] Adebayo, J. O. and Malomo, S. O. 2002. The Effect of Co-administration of Dihydroartemisinin with Vitamin E on the Activities of Cation ATPases in some Rat Tissues. Nigerian Journal of Pure and Applied Sciences, 17: 1245-1252.
[5] Ndem, J. I., Eteng, M. U. and Uwah, A. F. 2014. Effect of Hippocratea africana Root Bark Extract on Lipid Profile of Female and Male Albino Wistar Rats. Journal of Scientific Research and Reports, 3 (19): 2574-2583.
[6] Okokon, J. E., Ita, B. N. and Udokpoh, A. E. 2006. The in vivo Antimalarial Activities of Uvariae chamae and Hippocratea africana. Annals of Tropical Medicine and Parasitology, 100 (9): 585-590.
[7] Burkill, H. M. 1985. The useful plants of west tropical Africa (2nd ed.). Royal Botanic Gardens Sknew. pp 353-354.
[8] Atansuyi, K., Ibukun, E. O. and Ogunmyole, T. 2012. Antioxidant properties of free and bound phenolic extract of Jatropha tanjorensis in vitro. Journal of medicinal Plants research, 6 (31): 4667-7415.
[9] Falodun, A., Udu-Cosi, A. A., Erharuyi, O., Imieje, V., Falodun, E. J., Agbonlahor, O. and Hamann, M. T. 2013. Jatropha tanjorensis – Review of phytochemistry, pharmacology and pharmacotherapy. Journal of pharmaceutical and allied sciences, 10 (3): 1955-1964.
[10] Maina, R. N., Walsh, D., Gaddy, C., Hongo, G., Waitumbi, J., Otieno, L., Jones, D. and Ogutu, B. R. 2010. Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya. Malaria journal, 9 (Suppl 3): S4.
[11] Centre of Disease Control (CDC) and Prevention. 2013. Global health division of parasitic diseases and malaria, Atlanta, USA.
[12] Osonuga, I. O., Osonuga, O. A., Osonuga, A., Onadeko, A. A. and Osonuga, A. A. 2012. Effect of artemether on haematological parameters of heathy and uninfected adult Wistar rats. Asian pacific journal of tropical biomedicine, 2 (6): 493-495.
[13] Iwalewa, E. O., Adewunmi, C. O., Omisore, N. O., Adebanji, O. A. and Azikeet, C. K. 2005. Pro-antioxidant effects and cytoprotective potentials of nine edible vegetables in south west Nigeria. J. med. Food, 8: 539-544.
[14] Scharf, R. E. 2012. Drugs that affect platelet function. Semin thromb hemost 38 (8): 865-883.
[15] Mc Ewen, B. J. 2015. The influence of herbal medicine on platelet function and coagulation; A narrative review. Semin thromb hemost 41 (3): 300-314.
[16] Akpanabiatu, M. I., Akpan, H., Bassey, U. E. and Ufot, U. F. 2016. Infleunce of Nauclea latifolia Leaf Extracts on Some Haematological Parameters of Rats on Coconut Oil and Non-Coconut Oil Meals. European Journal of Medicinal Plants, 17 (4): 1-6.
[17] Finbarrs-Bello, E., Nto, N. J., Ikele, I. T., Sani, M. I. and Atuadu, V. 2016. Haematopoietic enhancing effect of ethanol seed extract of Citrullus lanatus (watermelon) on bone marrow of Wistar rats. European journal of medicinal plants, 17 (3): 1-7.
[18] Ndem, J. I., Otitoju O., Akpanabiatu, M. I., Uboh, F. E., Uwah, A. F. and Edet, O. A. (2013). Haematoprotective Property of Eremomastax speciosa (Hochst) on Experimentally Induced anaemic Wistar Rats. Annals of Biological Research, 4 (6): 356-360.
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    Jessie Idongesit Ndem, Eno-Obong Ikpeme Bassey, Blessing Obinaju Effiong, Utibe Evans Bassey, Sylvester Daniel Ini. (2019). Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract. Journal of Diseases and Medicinal Plants, 5(4), 69-73. https://doi.org/10.11648/j.jdmp.20190504.12

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    ACS Style

    Jessie Idongesit Ndem; Eno-Obong Ikpeme Bassey; Blessing Obinaju Effiong; Utibe Evans Bassey; Sylvester Daniel Ini. Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract. J. Dis. Med. Plants 2019, 5(4), 69-73. doi: 10.11648/j.jdmp.20190504.12

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    AMA Style

    Jessie Idongesit Ndem, Eno-Obong Ikpeme Bassey, Blessing Obinaju Effiong, Utibe Evans Bassey, Sylvester Daniel Ini. Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract. J Dis Med Plants. 2019;5(4):69-73. doi: 10.11648/j.jdmp.20190504.12

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  • @article{10.11648/j.jdmp.20190504.12,
      author = {Jessie Idongesit Ndem and Eno-Obong Ikpeme Bassey and Blessing Obinaju Effiong and Utibe Evans Bassey and Sylvester Daniel Ini},
      title = {Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract},
      journal = {Journal of Diseases and Medicinal Plants},
      volume = {5},
      number = {4},
      pages = {69-73},
      doi = {10.11648/j.jdmp.20190504.12},
      url = {https://doi.org/10.11648/j.jdmp.20190504.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20190504.12},
      abstract = {The haematopoietic potential of Jatropha tanjorensis leaf extract in Plasmodium berghi-berghi infected mice treated with Hippocratea africana root bark extract was investigated. Thirty (21) adult mice weighing 27 – 33g were divided into seven (7) groups with three (3) animals in each group. Group 1 served as normal control while Groups 2 – 7 were parasitized with Plasmodium berghi-berghi and Group 2 was the test control (parasitized and untreated) group. Group 3 was administered 8mg/kg bw of artemether-lumefantrine for 3 days. Group 4 and 5 received daily, 200mg/kg bw and 300mg/kg bw of extracts of Hippocratea africana and Jatropha tanjorensis respectively for 4 days. Group 6 received 8mg/kg bw of artemether-lumefantrine for 3 days followed with 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Group 7 was treated with 200mg/kg bw of Hippocratea africana root extract for 4 days followed by 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Significant anti-plasmodial activity was observed with artemether-lumefantrine and Hippocratea africana root bark extract administration. Plasmodium berghi-berghi infection induced alterations in haematological indices such as decreased RBC count, platelet count, haemoglobin concentration and heamatocrit and increased WBC count. Administration of Jatropha tanjorensis leaf extract showed improved haematological indices particularly in the red blood cell counts and haemoglobin concentration. Jatropha tanjorensis has haematopoietic activity in Plasmodium berghi-berghi infected mice treated Hippocratea africana root bark extract.},
     year = {2019}
    }
    

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    T1  - Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract
    AU  - Jessie Idongesit Ndem
    AU  - Eno-Obong Ikpeme Bassey
    AU  - Blessing Obinaju Effiong
    AU  - Utibe Evans Bassey
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    T2  - Journal of Diseases and Medicinal Plants
    JF  - Journal of Diseases and Medicinal Plants
    JO  - Journal of Diseases and Medicinal Plants
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    PB  - Science Publishing Group
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    AB  - The haematopoietic potential of Jatropha tanjorensis leaf extract in Plasmodium berghi-berghi infected mice treated with Hippocratea africana root bark extract was investigated. Thirty (21) adult mice weighing 27 – 33g were divided into seven (7) groups with three (3) animals in each group. Group 1 served as normal control while Groups 2 – 7 were parasitized with Plasmodium berghi-berghi and Group 2 was the test control (parasitized and untreated) group. Group 3 was administered 8mg/kg bw of artemether-lumefantrine for 3 days. Group 4 and 5 received daily, 200mg/kg bw and 300mg/kg bw of extracts of Hippocratea africana and Jatropha tanjorensis respectively for 4 days. Group 6 received 8mg/kg bw of artemether-lumefantrine for 3 days followed with 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Group 7 was treated with 200mg/kg bw of Hippocratea africana root extract for 4 days followed by 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Significant anti-plasmodial activity was observed with artemether-lumefantrine and Hippocratea africana root bark extract administration. Plasmodium berghi-berghi infection induced alterations in haematological indices such as decreased RBC count, platelet count, haemoglobin concentration and heamatocrit and increased WBC count. Administration of Jatropha tanjorensis leaf extract showed improved haematological indices particularly in the red blood cell counts and haemoglobin concentration. Jatropha tanjorensis has haematopoietic activity in Plasmodium berghi-berghi infected mice treated Hippocratea africana root bark extract.
    VL  - 5
    IS  - 4
    ER  - 

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Author Information
  • Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria

  • Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria

  • Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria

  • Department of Biochemistry, Faculty of Natural and Applied Sciences, Obong University, Etim Ekpo, Nigeria

  • Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria

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