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Analytical Study of Some Drug Brands Used to Treat Stomach Acidity

Received: 12 August 2025     Accepted: 25 August 2025     Published: 24 December 2025
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Abstract

This study is predicated on the assessment of the acid-neutralizing capacity of five distinct commercial brands of antacid. Antacids are prevalent substances utilized by individuals experiencing heightened gastric acidity, owing to their widespread availability in pharmacies. Consequently, this investigation concentrated on several brands of antacid medications, which function as weak bases that neutralize excess stomach acidity, thereby elevating the pH. The quantity of acid neutralized by each antacid was determined through back titration. The acid-neutralizing capacities of the brands were ranked as follows: A > B > E > D > C. The pH of the acid was measured after being heated to a temperature of 37°C, followed by the addition of the antacid, with a subsequent observation period of five minutes post-addition. The results regarding the impact of the antacids on acid pH were recorded as 6.95 for sample A, 6.74 for sample B, 4.58 for brand C, 1.76 for sample E, and 1.73 for sample D. An analysis of the findings indicates that sample A exhibits the highest neutralizing capacity (NC), whereas sample C demonstrates a significantly lower value of neutralizing capacity (NC).

Published in International Journal of Pharmacy and Chemistry (Volume 11, Issue 6)
DOI 10.11648/j.ijpc.20251106.12
Page(s) 119-125
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Antacid, Neutralizing Capacity, Titrimetric, Tablets, pH

References
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[2] Jwan Mohammed Ahmed. “Comparison of Acid-neutralizing capacity of antacids in Erbil City”. Zanco J. Med. Sci., (2021): Vol. 25(2).
[3] Xiaoxiao Yang 1, Yueyue Li, Yiyuan Sun, Mingming Zhang, Chuanguo Guo, Iqtida Ahmed Mirza, Yan-Qing Li “Vonoprazan: A Novel and Potent Alternative in the Treatment of Acid-Related Diseases”. (2018) 63(2): 302.
[4] David A. Johnson, Philip O. Katz, David Armstrong, Henry Cohen, Brendan C. Delaney, Colin W. Howden, Peter Katelaris, Radu I. Tutuian, Donald O. Castell” The Safety of Appropriate Use of Over-the-Counter Proton Pump Inhibitors: An Evidence-Based Review and Delphi Consensus. Drugs. (2017): 77: P. 547–561.
[5] Malfertheiner P, Megraud F, O'Morain C A, Gisbert J P, Kuipers E J, Axon A T, Bazzoli F, Gasbarrini A, Atherton J, Graham D Y, Hunt R, Moayyedi P, Rokkas T, Rugge M, Selgrad M, Suerbaum S, Sugano K, El-Omar E M; European Helicobacter and Microbiota Study Group and Consensus panel. (2017); 66(1): 6-30.
[6] Tripathi D. “Essentials of medical pharmacology”. 6th ed. New Delhi: Jeyapee; (2008): P. 627–38.
[7] Bhoir S, Bhagwath M. “Comparison of seven oxethazine containing antacids available in Indian market”. JAPI. (2013): 61: 400–3.
[8] Mandel, Daggy, Brodie, jacoby Alimet any pharma Cology Thera peuties. (2001). Vol.(14): 669-690.
[9] Jagadesh, Kandk and chidandg, K, N. “Study of Acid Neutralizing Copacity of varions Antacid Formulations”. Asian Journal of pharma ceutical Technology and Iunovation, (2015) 3(12): 1-6.
[10] Ph-D MSN, R, N, CNE, Col-By. Medically reviewed by Oebra Sullivan”. Louisa Richards on juty, 2020.
[11] Adel Amhamed Al-Ajtal, et al “analytical study of some medications used to treat stomach acidity”. Faculty of Science - Misrata University, Al-Satel Scientific Journal, (2021): 25. 35-44.
[12] Ahmed M. H., Momoh M. K “Determination of Effectiveness and Acid Neutralization Capacities (ANC) of some commercial Antacids Tablets”. Iconic Research Engineering Journals. (2021): vol. 5(1).
[13] Abdu, K. and Abbagana, M. “Evaluation of Neutralizing Capacity of Different Commercial Brands of Antacid Tablets”. ChemSearch Journal, (2015): 6(2): 32 – 34.
[14] Mohamed Yafout, Hicham Elhorr, Ibrahim Sbai El Otmani, and Youssef Khayati. “Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco”. Med Pharm Rep. (2022): Vol. 95(1).
[15] May Mohammed Jawad Al-Mudhafar, Shayma L. Abdulhadi and Ali Basim Talib. “Evaluation of Commercial Antacid Tablets in Iraq”. Der Pharma Chemica, (2016): 8(19): 283-288.
[16] Alalor C. A, Avbunudiogba J. A, Builders F. P, Okpara LO. “Evaluation of the Acid Neutralizing Capacity of Some Commercially Available Brands of Antacid Tablets in Nigeria”. East African Scholars Journal of Medical Sciences. (2019): Vol. 2, Iss-(1) 12-16.
Cite This Article
  • APA Style

    Benjuma, A. A., Eshkourfu, R. O., Naji, N. F. A., Al-Rabshi, R. M. (2025). Analytical Study of Some Drug Brands Used to Treat Stomach Acidity. International Journal of Pharmacy and Chemistry, 11(6), 119-125. https://doi.org/10.11648/j.ijpc.20251106.12

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    ACS Style

    Benjuma, A. A.; Eshkourfu, R. O.; Naji, N. F. A.; Al-Rabshi, R. M. Analytical Study of Some Drug Brands Used to Treat Stomach Acidity. Int. J. Pharm. Chem. 2025, 11(6), 119-125. doi: 10.11648/j.ijpc.20251106.12

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    AMA Style

    Benjuma AA, Eshkourfu RO, Naji NFA, Al-Rabshi RM. Analytical Study of Some Drug Brands Used to Treat Stomach Acidity. Int J Pharm Chem. 2025;11(6):119-125. doi: 10.11648/j.ijpc.20251106.12

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  • @article{10.11648/j.ijpc.20251106.12,
      author = {Aisha Alfituri Benjuma and Rabia Omar Eshkourfu and Najat Faraj Abu Naji and Ruwaida Muammar Al-Rabshi},
      title = {Analytical Study of Some Drug Brands Used to Treat Stomach Acidity},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {11},
      number = {6},
      pages = {119-125},
      doi = {10.11648/j.ijpc.20251106.12},
      url = {https://doi.org/10.11648/j.ijpc.20251106.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20251106.12},
      abstract = {This study is predicated on the assessment of the acid-neutralizing capacity of five distinct commercial brands of antacid. Antacids are prevalent substances utilized by individuals experiencing heightened gastric acidity, owing to their widespread availability in pharmacies. Consequently, this investigation concentrated on several brands of antacid medications, which function as weak bases that neutralize excess stomach acidity, thereby elevating the pH. The quantity of acid neutralized by each antacid was determined through back titration. The acid-neutralizing capacities of the brands were ranked as follows: A > B > E > D > C. The pH of the acid was measured after being heated to a temperature of 37°C, followed by the addition of the antacid, with a subsequent observation period of five minutes post-addition. The results regarding the impact of the antacids on acid pH were recorded as 6.95 for sample A, 6.74 for sample B, 4.58 for brand C, 1.76 for sample E, and 1.73 for sample D. An analysis of the findings indicates that sample A exhibits the highest neutralizing capacity (NC), whereas sample C demonstrates a significantly lower value of neutralizing capacity (NC).},
     year = {2025}
    }
    

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  • TY  - JOUR
    T1  - Analytical Study of Some Drug Brands Used to Treat Stomach Acidity
    AU  - Aisha Alfituri Benjuma
    AU  - Rabia Omar Eshkourfu
    AU  - Najat Faraj Abu Naji
    AU  - Ruwaida Muammar Al-Rabshi
    Y1  - 2025/12/24
    PY  - 2025
    N1  - https://doi.org/10.11648/j.ijpc.20251106.12
    DO  - 10.11648/j.ijpc.20251106.12
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 119
    EP  - 125
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20251106.12
    AB  - This study is predicated on the assessment of the acid-neutralizing capacity of five distinct commercial brands of antacid. Antacids are prevalent substances utilized by individuals experiencing heightened gastric acidity, owing to their widespread availability in pharmacies. Consequently, this investigation concentrated on several brands of antacid medications, which function as weak bases that neutralize excess stomach acidity, thereby elevating the pH. The quantity of acid neutralized by each antacid was determined through back titration. The acid-neutralizing capacities of the brands were ranked as follows: A > B > E > D > C. The pH of the acid was measured after being heated to a temperature of 37°C, followed by the addition of the antacid, with a subsequent observation period of five minutes post-addition. The results regarding the impact of the antacids on acid pH were recorded as 6.95 for sample A, 6.74 for sample B, 4.58 for brand C, 1.76 for sample E, and 1.73 for sample D. An analysis of the findings indicates that sample A exhibits the highest neutralizing capacity (NC), whereas sample C demonstrates a significantly lower value of neutralizing capacity (NC).
    VL  - 11
    IS  - 6
    ER  - 

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