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Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation

Received: 17 February 2021     Accepted: 9 March 2021     Published: 30 March 2021
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Abstract

The binding property of five (5) commonly used binders in metronidazole granule and tablet formulations was studied. The binders studied included gelatin, polyvinylpyrrolidone (PVP), carboxymethylcellulose (CMC), maize starch and guar gum. The binders were incorporated as 5%w/w of tablet weight in each case. The granules were formulated by the wet granulation technique while the tablets were prepared by compression. The properties of granules evaluated included flow rate, angle of repose, bulk and tapped densities, Hausner’s ratio, Carr’s index and moisture content. Tablet properties studied included weight uniformity, hardness, friability, thickness and diameter, disintegration time and dissolution rate. Results indicated that granules containing guar gum or PVP possessed flow properties superior to those of other binders, while those containing gelatin possessed the least flow property. In terms of packing characteristics, granules containing CMC were better than others. The mechanical strength of tablets containing gelatin, PVP or CMC was superior to those made with either guar gum or maize starch. In terms of release of metronidazole, tablets containing PVP, gelatin or guar gum were more efficient in releasing the drug, while those made with CMC was the least. On the basis of these, good metronidazole tablets could be formulated using PVP, gelatin or guar gum. On the other hand, maize starch or CMC may not be recommended as a binder for metronidazole tablets because of high friability or poor release respectively.

Published in International Journal of Pharmacy and Chemistry (Volume 7, Issue 2)
DOI 10.11648/j.ijpc.20210702.11
Page(s) 22-30
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Binding Property, Metronidazole Granule, Polyvinylpyrrolidone, Carboxymethylcellulose, Tablet Formulations

References
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[2] Mohammed, B. B., Isah, A. B., Apeji, Y. E. (2011). The role of acid-hydrolysed cassava starch as binders in paracetamol tablets, Journal of Pharmaceutical Research and Innovation, 4 (6): 9-12.
[3] Shailendra, P., Agrawal, S., Lodhi, B. S. (2012). Natural binding agents in tablet formation, International Journal of Pharmaceutical and Biological Archives 3 (3): 466-473.
[4] Ronelle, R. (2004). Synthetic excipents challenges all natural organics offer advantages/ challenges to developers and formulators. Advenster Communications Inc 1: 38-50.
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[8] Rubinstein, M. H. (2005). Tablets in Phamaceutics, the science of Dosage form design, Churchill Livingstone, London 34 (45) 457-463.
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Cite This Article
  • APA Style

    Akodu Busayo Odunayo, Fasuba Ilesanmi Kayode, Akawa Ayodeji Benjamin, Adu Isaac Adekola, Olasehinde Oluwaseun Ruth. (2021). Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation. International Journal of Pharmacy and Chemistry, 7(2), 22-30. https://doi.org/10.11648/j.ijpc.20210702.11

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    ACS Style

    Akodu Busayo Odunayo; Fasuba Ilesanmi Kayode; Akawa Ayodeji Benjamin; Adu Isaac Adekola; Olasehinde Oluwaseun Ruth. Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation. Int. J. Pharm. Chem. 2021, 7(2), 22-30. doi: 10.11648/j.ijpc.20210702.11

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    AMA Style

    Akodu Busayo Odunayo, Fasuba Ilesanmi Kayode, Akawa Ayodeji Benjamin, Adu Isaac Adekola, Olasehinde Oluwaseun Ruth. Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation. Int J Pharm Chem. 2021;7(2):22-30. doi: 10.11648/j.ijpc.20210702.11

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  • @article{10.11648/j.ijpc.20210702.11,
      author = {Akodu Busayo Odunayo and Fasuba Ilesanmi Kayode and Akawa Ayodeji Benjamin and Adu Isaac Adekola and Olasehinde Oluwaseun Ruth},
      title = {Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {7},
      number = {2},
      pages = {22-30},
      doi = {10.11648/j.ijpc.20210702.11},
      url = {https://doi.org/10.11648/j.ijpc.20210702.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20210702.11},
      abstract = {The binding property of five (5) commonly used binders in metronidazole granule and tablet formulations was studied. The binders studied included gelatin, polyvinylpyrrolidone (PVP), carboxymethylcellulose (CMC), maize starch and guar gum. The binders were incorporated as 5%w/w of tablet weight in each case. The granules were formulated by the wet granulation technique while the tablets were prepared by compression. The properties of granules evaluated included flow rate, angle of repose, bulk and tapped densities, Hausner’s ratio, Carr’s index and moisture content. Tablet properties studied included weight uniformity, hardness, friability, thickness and diameter, disintegration time and dissolution rate. Results indicated that granules containing guar gum or PVP possessed flow properties superior to those of other binders, while those containing gelatin possessed the least flow property. In terms of packing characteristics, granules containing CMC were better than others. The mechanical strength of tablets containing gelatin, PVP or CMC was superior to those made with either guar gum or maize starch. In terms of release of metronidazole, tablets containing PVP, gelatin or guar gum were more efficient in releasing the drug, while those made with CMC was the least. On the basis of these, good metronidazole tablets could be formulated using PVP, gelatin or guar gum. On the other hand, maize starch or CMC may not be recommended as a binder for metronidazole tablets because of high friability or poor release respectively.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Evaluation of the Binding Property of Some Binders in Metronidazole Tablet Formulation
    AU  - Akodu Busayo Odunayo
    AU  - Fasuba Ilesanmi Kayode
    AU  - Akawa Ayodeji Benjamin
    AU  - Adu Isaac Adekola
    AU  - Olasehinde Oluwaseun Ruth
    Y1  - 2021/03/30
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijpc.20210702.11
    DO  - 10.11648/j.ijpc.20210702.11
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 22
    EP  - 30
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20210702.11
    AB  - The binding property of five (5) commonly used binders in metronidazole granule and tablet formulations was studied. The binders studied included gelatin, polyvinylpyrrolidone (PVP), carboxymethylcellulose (CMC), maize starch and guar gum. The binders were incorporated as 5%w/w of tablet weight in each case. The granules were formulated by the wet granulation technique while the tablets were prepared by compression. The properties of granules evaluated included flow rate, angle of repose, bulk and tapped densities, Hausner’s ratio, Carr’s index and moisture content. Tablet properties studied included weight uniformity, hardness, friability, thickness and diameter, disintegration time and dissolution rate. Results indicated that granules containing guar gum or PVP possessed flow properties superior to those of other binders, while those containing gelatin possessed the least flow property. In terms of packing characteristics, granules containing CMC were better than others. The mechanical strength of tablets containing gelatin, PVP or CMC was superior to those made with either guar gum or maize starch. In terms of release of metronidazole, tablets containing PVP, gelatin or guar gum were more efficient in releasing the drug, while those made with CMC was the least. On the basis of these, good metronidazole tablets could be formulated using PVP, gelatin or guar gum. On the other hand, maize starch or CMC may not be recommended as a binder for metronidazole tablets because of high friability or poor release respectively.
    VL  - 7
    IS  - 2
    ER  - 

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Author Information
  • Department of Pharmaceutical Technology, University of Jos, Jos, Nigeria

  • Department of Pharmaceutical Technology, University of Jos, Jos, Nigeria

  • Department of Medical Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria

  • Department of Medical Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria

  • Department of Medical Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria

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